A5050035372- Renal Transplantation Outcomes and Treatments
- Dialysis and Renal Disease Management
- Pharmacological Effects and Toxicity Studies
- Iron Metabolism and Disorders
- Trace Elements in Health
- Nutrition and Health in Aging
- Parathyroid Disorders and Treatments
- Neuropeptides and Animal Physiology
- Chronic Kidney Disease and Diabetes
- Renal and Vascular Pathologies
- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Transplantation: Methods and Outcomes
- Folate and B Vitamins Research
- Muscle metabolism and nutrition
- Hemoglobinopathies and Related Disorders
- Vitamin K Research Studies
- Heavy Metal Exposure and Toxicity
- Potassium and Related Disorders
- Pregnancy and Medication Impact
- Metabolomics and Mass Spectrometry Studies
- Heart Failure Treatment and Management
- Metabolism and Genetic Disorders
- Neurological Complications and Syndromes
- Palliative Care and End-of-Life Issues
University Medical Center Groningen
2017-2025
University of Groningen
2017-2025
National Institute of Nutrition
2024
Netherlands School of Public Administration
2024
Dialyse Centrum Groningen
2023
Organ transplantation is a life-saving treatment for patients with end-stage disease, but survival rates after vary considerably. There now increasing evidence that the gut microbiome linked to of undergoing hematopoietic cell transplant, yet little known about role in solid organ transplantation. We analyzed 1370 fecal samples from 415 liver and 672 renal transplant recipients using shotgun metagenomic sequencing assess microbial taxonomy, metabolic pathways, antibiotic resistance genes,...
Abstract Muscle wasting, low protein intake, hypoalbuminemia, body mass, and chronic fatigue are prevalent in hemodialysis patients. Impaired creatine status may be an often overlooked, potential contributor to these symptoms. However, little is known about homeostasis We aimed elucidate patients by assessing intradialytic plasma changes as well intra- interdialytic losses of arginine, guanidinoacetate, creatinine. Additionally, we investigated associations concentrations with muscle mass...
Kidney transplantation is the best treatment for kidney failure in older patients. However, little known regarding changes health-related quality of life (HRQoL) from before to after and determinants HRQoL transplant recipients (KTR). We studied both, using data (≥65 years) patients waitlisted KTR 1 year TransplantLines Biobank Cohort Study. was assessed SF-36 questionnaire. included 145 (68% male, age 70 ± 4 115 at (73% years). Both mental (48.5 8.4 versus 51.2 7.7, p = 0.009) physical...
Serum creatinine is used as initial test to derive eGFR and confirmatory testing with serum cystatin C recommended when creatinine-based considered less accurate due deviant muscle mass. Low mass associated increased risk of premature mortality. However, the associations mortality remain unclear require further investigation better inform clinical decision-making.
Vitamin K deficiency is common among kidney transplant recipients (KTRs) and likely contributes to progressive vascular calcification stiffness. In this single-center, randomized, double-blind, placebo-controlled trial, we aimed investigate the effects of vitamin supplementation on primary end point, serum propensity (calciprotein particle maturation time, T50), secondary points arterial stiffness (pulse wave velocity [PWV]) status in 40 K-deficient KTRs (plasma dephosphorylated...
Abstract Creatine is a natural nitrogenous organic acid that integral to energy metabolism and crucial for proper cell functioning. The kidneys are involved in the first step of creatine production. With kidney transplantation being gold-standard treatment end-stage disease, transplant recipients (KTR) may be at risk impaired synthesis. We aimed compare homeostasis between KTR controls. Plasma urine concentrations arginine, glycine, guanidinoacetate, creatinine were measured 553 168 healthy...
Fatigue and impaired health-related quality of life (HRQoL) are common among kidney transplant recipients (KTR). We hypothesized that both may partially be attributable to poor sleep.Cross-sectional longitudinal data KTR enrolled in the TransplantLines Biobank Cohort Study were used. Sleep was assessed using Pittsburgh Quality Index questionnaire. Individual strength (i.e. a composite fatigue, concentration, motivation physical activity), societal participation HRQoL validated...
Delayed graft function after kidney transplantation is common and increases morbidity health care costs. There evidence that endotrophin, a specific fragment of pro-collagen type VI, promotes the inflammatory response in diseases. We tested hypothesis pretransplant endotrophin transplant recipients may be associated with risk delayed function. Pretransplant plasma was assessed using an enzyme-linked immunosorbent assay three independent cohorts 806 recipients. The primary outcome function,...
Survival of kidney transplant recipients (KTR) is low compared with the general population. Low muscle mass and strength may contribute to lower survival, but practical measures status suitable for routine care have not been evaluated their association long-term survival relation each other in a large cohort KTR.
Kidney transplant recipients (KTRs) experience more fatigue, anxiety, and depressive symptoms lower concentration health-related quality of life (HRQoL) compared with the general population. Anemia is a potential cause that well-recognized treated. Iron deficiency, however, often unrecognized, despite its detrimental effects related to unrelated anemia. We investigated interplay anemia, iron patient-reported outcomes in 814 outpatient KTRs (62% male, age 56 ± 13 years) enrolled...
Oxidative stress is associated with adverse outcomes in kidney transplant recipients (KTR), including graft failure, morbidity, and mortality. Since both exercise training dietary modifications have the potential to improve redox status, we aimed investigate mitigating effects of or plus diet intervention on circulating levels free thiols (R-SH) as marker systemic status KTR. We conducted a post-hoc analysis Active Care after Transplantation (ACT) study, randomized controlled lifestyle trial...
Abstract Background and hypothesis Trimethylamine N-oxide (TMAO) is a pro-atherosclerotic molecule produced by intestinal microbiome. TMAO has been linked to increased mortality risk in chronic kidney disease, but its effect transplant recipients (KTR) unclear. We investigated the pre-post-transplantation plasma change, association of post-transplantation with all-cause KTR. Methods This prospective study included two cohorts. Cohort A comprised 623 KTR from TransplantLines Biobank Study...