A5003902104- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Genetic Neurodegenerative Diseases
- Botulinum Toxin and Related Neurological Disorders
- Transcranial Magnetic Stimulation Studies
- Neuroscience and Neural Engineering
- EEG and Brain-Computer Interfaces
- Glycogen Storage Diseases and Myoclonus
- Clostridium difficile and Clostridium perfringens research
- Parkinson's Disease and Spinal Disorders
- Hereditary Neurological Disorders
- Advanced MRI Techniques and Applications
- Genetics and Neurodevelopmental Disorders
- Cerebral Palsy and Movement Disorders
- Neurogenetic and Muscular Disorders Research
- Neurological diseases and metabolism
- Gastrointestinal motility and disorders
- Autism Spectrum Disorder Research
- Advanced Neuroimaging Techniques and Applications
- Medical Imaging and Pathology Studies
- Dysphagia Assessment and Management
- Functional Brain Connectivity Studies
- Voice and Speech Disorders
- Systemic Sclerosis and Related Diseases
- Nerve Injury and Rehabilitation
Leiden University Medical Center
2016-2024
Haga Hospital
2015-2024
University Medical Center
2024
Leiden University
2016-2021
Amsterdam UMC Location University of Amsterdam
2009-2018
University of Amsterdam
2007-2016
University Medical Center Groningen
2015
University of Groningen
2015
Amsterdam University of the Arts
2015
Vrije Universiteit Amsterdam
2013
Deep brain stimulation (DBS) is associated with significant improvement of motor complications in patients severe Parkinson's disease after some 6–12 months treatment. Long-term results a large number have been reported only from single study centre. We report 69 treated bilateral DBS the subthalamic nucleus (STN, n = 49) or globus pallidus internus (GPi, 20) included multicentre study. Patients were assessed preoperatively and at 1 year 3–4 years surgery. The primary outcome measure was...
Abstract We report the 5 to 6 year follow‐up of a multicenter study bilateral subthalamic nucleus (STN) and globus pallidus internus (GPi) deep brain stimulation (DBS) in advanced Parkinson's disease (PD) patients. Thirty‐five STN patients 16 GPi were assessed at years after DBS surgery. Primary outcome measure was effect on motor Unified Disease Rating Scale (UPDRS) with prospective cross‐over double‐blind assessment without medications (stimulation randomly switched or off). Secondary...
The aim of this study was to investigate whether directional steering through a novel 32-contact electrode is safe and can modulate the thresholds for beneficial side effects stimulation.The single-center, performance safety study. Double-blind intraoperative evaluations therapeutic benefit were performed in 8 patients with Parkinson disease while stimulating randomized order spherical mode 4 different modes electrode, monopolar commercial electrode. In addition, simultaneous recordings...
To compare motor symptoms, cognition, mood, and behavior 3 years after deep brain stimulation (DBS) of the globus pallidus pars interna (GPi) subthalamic nucleus (STN) in advanced Parkinson disease (PD).Patients with PD eligible for DBS were randomized to bilateral GPi STN (1:1). The primary outcome measures (1) improvement symptoms off-drug phase measured Unified Disease Rating Scale (UPDRS) (2) a composite score cognitive, behavioral effects, inability complete follow-up at 36 months...
Abstract Among 30 Parkinson's disease patients who received high frequency stimulation of the subthalamic nucleus, 5 developed remarkable disorders mood or sexual behavior after implant. We describe 2 men mania and hypersexuality a few days implant that lasted for some months then gradually disappeared spontaneously. © 2002 Movement Disorder Society
To investigate cognitive and behavioural effects of bilateral lead implants for high frequency stimulation (HFS) the subthalamic nucleus in patients with Parkinson's disease; to discriminate between HFS surgical intervention on function by carrying out postoperative assessments stimulators turned or off.Motor, cognitive, behavioural, functional were undertaken 20 disease before implantation then at three, six, 12 months afterwards. Nine also examined 18 after surgery. Postoperative carried...
We assessed the effects of deep brain stimulation subthalamic nucleus (STN-DBS) or internal pallidum (GPi-DBS) on health-related quality life (HrQoL) in patients with advanced Parkinson's disease participating a previously reported multicenter trial. Sickness Impact Profile (SIP) questionnaires were available for analysis subgroup n = 20/20 GPi-DBS and 45/49 STN-DBS at baseline, 6 36 months. The SIP provides physical dimension psychosocial sum score 12 category scores: Alertness/Intellectual...
Intraoperative microelectrode recording (MER) for targeting during deep brain stimulation (DBS) procedures has been evaluated over a period of 4 years, in 57 consecutive patients with Parkinson’s disease, who received DBS the subthalamic nucleus (STN-DBS), and 28 either dystonia (23) or disease (five), whom internal segment globus pallidus (GPi-DBS) was targeted. The procedure one-stage bilateral stereotactic approach using combined electrode both MER macrostimulation. Up to five...
Brain sensing devices are approved today for Parkinson's, essential tremor, and epilepsy therapies. Clinical decisions implants often influenced by the premise that patients will benefit from using technology. However, artifacts, such as ECG contamination, can render treatments unreliable. Therefore, clinicians need to understand how surgical may affect artifact probability.Investigate neural signal contamination with activity in enabled neurostimulation systems, particular clinical choices...
Twenty-two patients with PD received bilateral implants for high frequency stimulation of the subthalamic nucleus. The were treated more than 1 year (up to 36 months). At last visit, Unified Parkinson Disease Rating Scale (UPDRS) motor score without medication improved by 50.2% (p < 0.001) and UPDRS activities daily living 68.4% 0.001). most common long-lasting adverse events hypophonia dysarthria; transient increased sexuality mania. surgical procedure induced intraoperative psychosis in...
To assess the long-term cognitive and behavioural outcome after bilateral deep brain stimulation (DBS) of subthalamic nucleus (STN) in patients affected by Parkinson's disease, with a 5-year follow-up surgery.11 disease treated DBS STN underwent assessments before implantation, 1 5 years surgery. Postoperative were carried out stimulators turned on.A year surgery, there was marginally significant decline on letter verbal fluency task (p = 0.045) improvement Mini-Mental State Examination...
BACKGROUND Accurate electrode position is important for the efficacy of deep brain stimulation (DBS). Several reports revealed errors during stereotactic surgery due to cerebrospinal fluid (CSF) loss and subdural air invasion. Because resolves in weeks after returns its original position, DBS electrodes may become displaced postoperatively. OBJECTIVE To quantitatively assess postoperative displacement relation METHODS We retrospectively analyzed 14 patients with advanced Parkinson disease...
Abstract Mutations in THAP1 , a gene encoding nuclear pro‐apoptotic protein, have been associated with DYT6 dystonia. First reports on the phenotype of dystonia show an early onset predominant cranio‐cervical and laryngeal involvement. Here we assessed frequency mutation carriers large Dutch cohort adult‐onset (≥26 years) (n = 388) early‐onset 67) patients. We describe patients their response GPi DBS. Overall, 3 nonsynonymous heterozygous mutations were detected group (4.5%). Two families...
Objective: To assess the neuropsychological outcome 12 months after bilateral deep brain stimulation (DBS) of globus pallidus pars interna (GPi) or subthalamic nucleus (STN) for advanced Parkinson disease. Methods: We randomly assigned patients to receive either GPi DBS STN DBS. Standardized tests were performed at baseline and months. Patients study assessors masked treatment allocation. Results: Univariate analysis change scores indicated group differences on Stroop word reading color...
Background Individual motor improvement after deep brain stimulation (DBS) of the subthalamic nucleus (STN) for Parkinson’s disease (PD) varies considerably. Stereotactic targeting dorsolateral sensorimotor part STN is considered paramount maximising effectiveness, but studies employing midcommissural point (MCP) as anatomical reference failed to show correlation between DBS location and improvement. The medial border may provide better insight in relationship clinical outcome. Methods Motor...