Gerjan Navis
A5010367070- Blood Pressure and Hypertension Studies
- Chronic Kidney Disease and Diabetes
- Sodium Intake and Health
- Dialysis and Renal Disease Management
- Nutritional Studies and Diet
- Hormonal Regulation and Hypertension
- Renin-Angiotensin System Studies
- Renal Transplantation Outcomes and Treatments
- Nutrition and Health in Aging
- Parathyroid Disorders and Treatments
- Renal Diseases and Glomerulopathies
- Heart Failure Treatment and Management
- Renal and Vascular Pathologies
- Renal function and acid-base balance
- Potassium and Related Disorders
- Genetic Associations and Epidemiology
- Diet and metabolism studies
- Electrolyte and hormonal disorders
- Organ Donation and Transplantation
- Birth, Development, and Health
- Vitamin D Research Studies
- Obesity, Physical Activity, Diet
- Folate and B Vitamins Research
- Organ Transplantation Techniques and Outcomes
- Diabetes Treatment and Management
University Medical Center Groningen
2016-2025
University of Groningen
2016-2025
Nierstichting
2022
Dialyse Centrum Groningen
2003-2021
Medisch Centrum Leeuwarden
2016-2018
Radboud University Medical Center
2016-2018
Radboud University Nijmegen
2016-2018
Jordan University of Science and Technology
2018
Vanderbilt University Medical Center
2018
University of Amsterdam
2018
Current equations for estimated glomerular filtration rate (eGFR) that use serum creatinine or cystatin C incorporate age, sex, and race to estimate measured GFR. However, in eGFR is a social not biologic construct.
CKD prevalence estimation is central to management and prevention planning at the population level. This study estimated in European adult general investigated international variation by age, sex, presence of diabetes, hypertension, obesity. We collected data from 19 general-population studies 13 countries. stages 1–5 was defined as eGFR<60 ml/min per 1.73 m 2 , calculated CKD-Epidemiology Collaboration equation, or albuminuria >30 mg/g, 3–5 . age- sex-standardized 27 Member States...
Postoperative renal function deterioration is a serious complication after cardiac surgery with cardiopulmonary bypass and associated increased in-hospital mortality. However, the long-term prognosis of patients postoperative not fully determined yet. Therefore, both mortality survival were studied in deterioration. Included 843 who underwent 1991. (increase serum creatinine first week at least 25%) occurred 145 (17.2%) patients. In these patients, was 14.5%, versus 1.1% without (P < 0.001)....
Hypertension is a heritable and major contributor to the global burden of disease. The sum rare common genetic variants robustly identified so far explain only 1%–2% population variation in BP hypertension. This suggests existence more undiscovered variants. We conducted genome-wide association study 1,621 hypertensive cases 1,699 controls follow-up validation analyses 19,845 16,541 using an extreme case-control design. locus on chromosome 16 5′ region Uromodulin (UMOD; rs13333226, combined...
The risk for multifactorial diseases is determined by factors that frequently apply across disorders (universal factors). To investigate unresolved issues on etiology of and individual's susceptibility to diseases, research focus should shift from single determinant-outcome relations effect modification universal factors. We present a model based factor, outcome measure, several modifiers. Outcome measures can be disease overriding, such as clustering disease, frailty quality life. "Life...
There is large interindividual variability in the antiproteinuric response to blockade of renin-angiotensin-aldosterone system (RAAS). A low-sodium diet or addition diuretics enhances effects RAAS on proteinuria and BP, but efficacy combination these interventions unknown. Therefore, this randomized, double-blind, placebo-controlled trial determine separate combined a hydrochlorothiazide (HCT) BP was performed. In 34 proteinuric patients without diabetes, mean baseline 3.8 g/d, reduced by...
No data are available on the absolute risk of either venous thromboembolism (VTE) or arterial (ATE) in patients with nephrotic syndrome. Reported risks based multiple case reports and small studies mostly short-term follow-up. We assessed VTE ATE a large, single-center, retrospective cohort study attempted to identify predictive factors these patients.A total 298 consecutive syndrome (59% men; mean age, 42+/-18 years) were enrolled. Mean follow-up was 10+/-9 years. Nephrotic defined by...
High sodium intake limits the antihypertensive and antiproteinuric effects of angiotensin-converting enzyme (ACE) inhibitors in patients with CKD; however, whether dietary also associates progression to ESRD is unknown. We conducted a post hoc analysis first second Ramipril Efficacy Nephropathy trials evaluate association proteinuria among 500 CKD without diabetes who were treated ramipril (5 mg/d) monitored serial 24-hour urinary creatinine measurements. Urinary sodium/creatinine excretion...
Alcohol consumption is a moderately heritable trait, but the genetic basis in humans largely unknown, despite its clinical and societal importance. We report genome-wide association study meta-analysis of ∼2.5 million directly genotyped or imputed SNPs with alcohol (gram per day kilogram body weight) among 12 population-based samples European ancestry, comprising 26,316 individuals, replication genotyping an additional 21,185 individuals. SNP rs6943555 autism susceptibility candidate 2 gene...