A5009170192- Invertebrate Immune Response Mechanisms
- Genetic Associations and Epidemiology
- Plant Gene Expression Analysis
- Plant Physiology and Cultivation Studies
- Liver Disease Diagnosis and Treatment
- Postharvest Quality and Shelf Life Management
- Plant biochemistry and biosynthesis
- Spinal Cord Injury Research
- Peptidase Inhibition and Analysis
- Nerve injury and regeneration
- Plant nutrient uptake and metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Enzyme Production and Characterization
- Phytochemicals and Antioxidant Activities
- Developmental Biology and Gene Regulation
- Adipose Tissue and Metabolism
- Diabetic Foot Ulcer Assessment and Management
- Cholesterol and Lipid Metabolism
- Immune cells in cancer
- Pressure Ulcer Prevention and Management
- Neurogenesis and neuroplasticity mechanisms
- Microplastics and Plastic Pollution
- Enzyme Structure and Function
- Birth, Development, and Health
- Diet, Metabolism, and Disease
First Affiliated Hospital of Xinjiang Medical University
2025
Xinjiang Medical University
2025
Tsinghua University
2023-2025
National Clinical Research Center for Digestive Diseases
2023-2024
First Affiliated Hospital Zhejiang University
2023-2024
State Key Laboratory of Diagnosis and Treatment of Infectious Diseases
2023-2024
Zhejiang Provincial People's Hospital
2024
Jiangxi Agricultural University
2020-2023
Henan Academy of Agricultural Sciences
2019-2023
State Key Joint Laboratory of Environment Simulation and Pollution Control
2023
Abstract Background Cardiovascular diseases and their associated risk factors remain the main cause of mortality in western societies. In order to assess prevalence cardiovascular (CVRFs) Caucasian population Lausanne, Switzerland, we conducted a population-based study (Colaus Study). A secondary aim CoLaus will be determine new genetic determinants with CVRFs. Methods Single-center, cross-sectional including random sample 6,188 extensively phenotyped subjects (3,251 women 2,937 men) aged 35...
Alcohol consumption is a moderately heritable trait, but the genetic basis in humans largely unknown, despite its clinical and societal importance. We report genome-wide association study meta-analysis of ∼2.5 million directly genotyped or imputed SNPs with alcohol (gram per day kilogram body weight) among 12 population-based samples European ancestry, comprising 26,316 individuals, replication genotyping an additional 21,185 individuals. SNP rs6943555 autism susceptibility candidate 2 gene...
Enterokinase is a protease of the intestinal brush border that specifically cleaves acidic propeptide from trypsinogen to yield active trypsin. This cleavage initiates cascade proteolytic reactions leading activation many pancreatic zymogens. The full-length cDNA sequence for bovine enterokinase and partial human were determined. deduced amino acid sequences indicate two-chain derived single-chain precursor. Membrane association may be mediated by potential signal-anchor near terminus....
Fine-tuning of gene expression is crucial for protein and pathway construction, but it still faces formidable challenges due to the hierarchical regulation at multiple levels in a context-dependent manner. In this study, we defined optimal targeting windows CRISPRa CRISPRi dCas9-α/ω system, demonstrated that system could act as single master regulator simultaneously activate repress different genes by designing position-specific gRNAs. The application scope dCas9-ω was further expanded newly...
Spinal cord injury (SCI) is one of the most challenging clinical issues. It characterized by disruption neural circuitry and connectivity, resulting in neurological disability. Adipose-derived stem cells (ADSCs) serve as a promising source therapeutic for SCI treatment. However, outcomes direct ADSCs transplantation are limited presence an inflammatory microenvironment. Herein, cell-adaptable neurogenic (CaNeu) hydrogel was developed delivery vehicle to promote neuronal regeneration after...
Abstract Kynurenine derivative 3‐hydroxyanthranilic acid (3‐HAA) is known to regulate the immune system and exhibit anti‐inflammatory activity by inhibiting T‐cell cytokine secretion influencing macrophage activity. However, definite role of 3‐HAA in immunomodulation hepatocellular carcinoma (HCC) largely unexplored. An orthotopic HCC model treated with intraperitoneal injection developed. Furthermore, cytometry time‐of‐flight (CyTOF) single‐cell RNA sequencing (scRNA‐seq) analyses are...
Enteropeptidase, also known as enterokinase, initiates the activation of pancreatic hydrolases by cleaving and activating trypsinogen. Enteropeptidase is synthesized a single-chain protein, whereas purified enteropeptidase contains ≈47-kDa serine protease domain (light chain) disulfide-linked ≈120-kDa heavy chain. The chain an amino-terminal membrane-spanning segment several repeated structural motifs unknown function. To study role in substrate recognition, secreted variants recombinant...
Dietary nutrients provide macromolecules necessary for organism growth and development. In response to animal feeding, evolutionarily conserved signaling pathways are activated, leading increased rates of cell proliferation tissue growth. It remains unclear how different types within developing tissues coordinate in dietary whether coordinated is proper function. Using the early Drosophila larval brain, we asked nutrient-dependent neural stem cells (neuroblasts), glia, trachea among these...