A5019717619- Obesity, Physical Activity, Diet
- Birth, Development, and Health
- Nutritional Studies and Diet
- Health, Environment, Cognitive Aging
- Head and Neck Cancer Studies
- Physical Activity and Health
- Cleft Lip and Palate Research
- Diet and metabolism studies
- Fatty Acid Research and Health
- Children's Physical and Motor Development
- Folate and B Vitamins Research
- Nutrition and Health in Aging
- Cancer-related molecular mechanisms research
- Vitamin C and Antioxidants Research
- Craniofacial Disorders and Treatments
- Epigenetics and DNA Methylation
- Body Composition Measurement Techniques
- Enhanced Recovery After Surgery
- Genetic Associations and Epidemiology
- Pregnancy and preeclampsia studies
- Antioxidant Activity and Oxidative Stress
- Consumer Attitudes and Food Labeling
- Cardiac, Anesthesia and Surgical Outcomes
- Nutrition, Genetics, and Disease
- Health and Lifestyle Studies
Mayo Clinic
2025
University of Bristol
2015-2024
University Of Bristol Dental Hospital
2015-2024
University Hospitals Bristol NHS Foundation Trust
2015-2024
National Institute for Health Research
2015-2024
Mayo Clinic in Arizona
2022-2024
University of Toronto
2024
NIHR Bristol Biomedical Research Centre
2014-2023
St. Olaf College
2022
University Hospitals Bristol and Weston NHS Foundation Trust
2022
Obesity is a serious international health problem that increases the risk of several common diseases. The genetic factors predisposing to obesity are poorly understood. A genome-wide search for type 2 diabetesâsusceptibility genes identified variant in FTO (fat mass and associated) gene predisposes diabetes through an effect on body index (BMI). An additive association with BMI was replicated 13 cohorts 38,759 participants. 16% adults who homozygous allele weighed about 3 kilograms more...
The Avon Longitudinal Study of Parents and Children (ALSPAC) is a transgenerational prospective observational study investigating influences on health development across the life course. It considers multiple genetic, epigenetic, biological, psychological, social other environmental exposures in relation to similarly diverse range health, developmental outcomes. Recruitment sought enrol pregnant women Bristol area UK during 1990–92; this was extended include additional children eligible...
Summary The Avon Longitudinal Study of Children and Parents (ALSPAC) was established to understand how genetic environmental characteristics influence health development in parents children. All pregnant women resident a defined area the South West England, with an expected date delivery between 1st April 1991 31st December 1992, were eligible 13 761 (contributing 867 pregnancies) recruited. These have been followed over last 19–22 years completed up 20 questionnaires, had detailed data...
To identify risk factors in early life (up to 3 years of age) for obesity children the United Kingdom.Prospective cohort study.Avon longitudinal study parents and children, Kingdom.8234 aged 7 a subsample 909 (children focus) with data on additional growth related obesity.Obesity at age years, defined as body mass index (3) 95th centile relative reference UK population 1990.Eight 25 putative were associated final models: parental (both parents: adjusted odds ratio, 10.44, 95% confidence...
to test early nutritional interventions and prospective observational cohorts. RCTs are generally accepted as methodologically the best approach for informing health policy. They can equalise unknown well known confounding factors so demonstrate causation; they permit estimation of effect size be used assess likely economic
<h3>Objective:</h3> To measure the levels and patterns of physical activity, using accelerometers, 11-year-old children participating in Avon Longitudinal Study Parents Children (ALSPAC). <h3>Design:</h3> Cross-sectional analysis. <h3>Setting:</h3> ALSPAC is a birth cohort study located former county Avon, southwest England. This used data collected when were 11 years old. <h3>Participants:</h3> 5595 (2662 boys, 2933 girls). The are offspring women recruited to during 1991–2. median age (95%...
We sought to examine the association of gestational weight gain (GWG) and prepregnancy with offspring adiposity cardiovascular risk factors.Data from 5154 (for blood pressure) 3457 assays) mother-offspring pairs a UK prospective pregnancy cohort were used. Random-effects multilevel models used assess incremental GWG (median range repeat measures per woman: 10 [1, 17]). Women who exceeded 2009 Institute Medicine-recommended more likely have greater body mass index, waist, fat mass, leptin,...
Background Previous studies have been unable to characterise the association between physical activity and obesity, possibly because most relied on inaccurate measures of obesity. Methods Findings We carried out a cross sectional analysis 5,500 12-year-old children enrolled in Avon Longitudinal Study Parents Children. Total minutes moderate vigorous (MVPA) were measured using Actigraph accelerometer. Fat mass obesity (defined as top decile fat mass) Lunar Prodigy dual x-ray emission...
Time spent in "sports/outdoor activity" has shown a negative association with incident myopia during childhood. We investigated the of time outdoors and physical activity separately.Participants Avon Longitudinal Study Parents Children (ALSPAC) were assessed by noncycloplegic autorefraction at ages 7, 10, 11, 12, 15 years, classified as myopic (≤-1 diopters) or emmetropic/hyperopic (≥-0.25 each visit (N = 4,837-7,747). Physical age 11 years was measured objectively using an accelerometer,...
Background: Objective methods can improve accuracy of physical activity measurement in field studies but uncertainties remain about their use. Methods: Children age 11 years from the Avon Longitudinal Study Parents and (ALSPAC), were asked to wear a uni-axial accelerometer (MTI Actigraph) for 7 days. Results: Of 7159 children who attended assessment, 5595 (78%) provided valid measures. The reliability coefficient 3 days recording was .7 power detect difference 0.07 SDs ( P ≤ .05) > 90%....
This is the first prospective cohort study of association between bone mass and fracture risk in childhood. A total 6213 children 9.9 years age were followed for 24 months. Results showed an 89% increased per SD decrease size-adjusted BMC.
<b>Objectives</b> To examine the prospective associations between body mass index (BMI), waist circumference, and fat in childhood cardiovascular risk factors at age 15-16. <b>Design</b> Prospective cohort study. <b>Setting</b> Avon Longitudinal Study of Parents Children. <b>Participants</b> 5235 children aged 9-12 start <b>Main exposures </b>BMI, determined by dual energy x ray absorptiometry, assessed outcome measures</b> Systolic diastolic blood pressure concentrations fasting glucose,...