Annika Steffen
A5013813107- Nutritional Studies and Diet
- Nutrition and Health in Aging
- Cancer Risks and Factors
- Obesity, Physical Activity, Diet
- Diet and metabolism studies
- Colorectal Cancer Screening and Detection
- Head and Neck Cancer Studies
- Pneumonia and Respiratory Infections
- Health and Medical Studies
- Endometrial and Cervical Cancer Treatments
- Vaccine Coverage and Hesitancy
- Global Cancer Incidence and Screening
- Folate and B Vitamins Research
- Ovarian cancer diagnosis and treatment
- Alcohol Consumption and Health Effects
- Cervical Cancer and HPV Research
- Esophageal Cancer Research and Treatment
- Virology and Viral Diseases
- Gastric Cancer Management and Outcomes
- Nutrition, Genetics, and Disease
- Liver Disease Diagnosis and Treatment
- Consumer Attitudes and Food Labeling
- Multiple and Secondary Primary Cancers
- Cancer, Lipids, and Metabolism
- Genetic factors in colorectal cancer
Robert Koch Institute
2021-2023
Central Institute of Mental Health
2018-2020
German Institute of Human Nutrition
2009-2018
National Institute for Public Health and the Environment
2016
National Cancer Institute
2015
University of South Australia
2014
Danish Cancer Society
2011-2012
Imperial College London
2011-2012
Heidelberg University
2011-2012
University Hospital Heidelberg
2011-2012
The hypothesis of 'metabolically healthy obesity' implies that, in the absence metabolic dysfunction, individuals with excess adiposity are not at greater cardiovascular risk. We tested this a large pan-European prospective study.
A total of 308,036 women were selected from the European Prospective Investigation into Cancer and Nutrition (EPIC) study to evaluate association between tobacco smoking risk cervical intraepithelial neoplasia grade 3 (CIN3)/carcinoma in situ (CIS) invasive cancer (ICC). At baseline, participants completed a questionnaire provided blood samples. During mean follow-up time 9 years, 261 ICC cases 804 CIN3/CIS reported. In nested case-control study, baseline sera 609 1,218 matched controls...
To examine the association of red meat and whole-grain bread consumption with plasma levels biomarkers related to glucose metabolism, oxidative stress, inflammation obesity.Our cross-sectional study was based on 2,198 men women who were selected as a sub-cohort for an investigation biological predictors diabetes cardiovascular diseases from European Prospective Investigation into Cancer Nutrition-Potsdam study. Circulating glycated hemoglobin, adiponectin, hs-CRP, gamma-glutamyltransferase,...
Background In addition to HPV, high parity and hormonal contraceptives have been associated with cervical cancer (CC). However, most of the evidence comes from retrospective case-control studies. The aim this study is prospectively evaluate associations between factors risk developing intraepithelial neoplasia grade 3 (CIN3)/carcinoma in situ (CIS) invasive (ICC). Methods Findings We followed a cohort 308,036 women recruited European Prospective Investigation into Cancer Nutrition (EPIC)...
Abstract Background Depression is frequently accompanied by other mental disorders and various somatic diseases; however, previous comorbidity studies often relied on self-reported data have not simultaneously assessed the entire spectrum of diagnoses. The aim to provide a complete picture depression in routine outpatient care high income country with relatively well equipped health system. Methods Using ambulatory claims covering 87% German population (age 15+), we designed cross-sectional...
It is well established that parity and use of oral contraceptives reduce the risk ovarian cancer, but associations with other reproductive variables are less clear. We examined contraceptive factors cancer in European Prospective Investigation into Cancer Nutrition. Among 327 396 eligible women, 878 developed over an average 9 years. Hazard ratios (HRs) 95% confidence intervals (CIs) were estimated using Cox proportional hazard models stratified by centre age, adjusted for smoking status,...
Objective To investigate trends in obesity prevalence recent years and to predict the 2015 European populations. Methods Data of 97 942 participants from seven cohorts involved Prospective Investigation into Cancer Nutrition (EPIC) study participating Diogenes project (named as "Diogenes cohort" following) with weight measurements at baseline follow-up were used future logistic linear non-linear (leveling off) regression models. In addition, leveling off models fitted EPIC-Potsdam dataset...
There is an urgent need to improve lung cancer risk assessment because current screening criteria miss a large proportion of cases.
Recent cohort studies suggest that increased breast cancer risks were associated with longer smoking duration, higher pack-years and a dose-response relationship increasing of between menarche first full-term pregnancy (FFTP). Studies comprehensive quantitative life-time measures passive an association dose risk. We conducted study within the European Prospective Investigation into Cancer Nutrition to examine active risk invasive possible effect modification by known factors. Among 322,988...
Menopausal hormone therapy (MHT) is characterized by use of different constituents, regimens and routes administration. We investigated the association between types MHT breast cancer risk in EPIC cohort study. The analysis based on data from 133,744 postmenopausal women. Approximately women contributed to this analysis. Information was derived country-specific self-administered questionnaires with a single baseline assessment. Incident cancers were identified through population registries...
In a previous European prospective investigation into cancer and nutrition (EPIC) analysis, we found an inverse association between total intake of vegetables, onion garlic, risk intestinal gastric (GC) citrus fruit cardia GC. The aim this study is to reanalyze the effect vegetables (F&V), based on longer follow-up twice number GC cases. Subjects are 477,312 men women mostly aged 35 70 years participating in EPIC cohort, including 683 adenocarcinomas with 11 follow-up. Information diet...
The aim of this study was to prospectively examine the association between body iron stores and risk type 2 diabetes. We designed a case–cohort among 27,548 individuals within population-based European Prospective Investigation into Cancer Nutrition (EPIC)-Potsdam study. During 7 years follow-up, 849 incident cases diabetes were identified. Of these, 607 remained for analyses after exclusion participants with missing data or abnormal glucose levels at baseline. A sub-cohort 2,500 randomly...
Background Dietary factors such as low energy density and glycemic index were associated with a lower gain in abdominal adiposity. A better understanding of which food groups/items contribute to these associations is necessary. Objective To ascertain the association consumption on prospective annual changes "waist circumference for given BMI" (WCBMI), proxy Design We analyzed data from 48,631 men women 5 countries participating European Prospective Investigation into Cancer Nutrition (EPIC)...
Studies based on health insurance funds unanimously indicate a rise in administrative prevalence of depression, while population surveys with standardized diagnostic procedures do not. We describe recent trends the depressive disorders as diagnosed routine care from 2009-2017 Germany. used nationwide ambulatory claims data all residents statutory insurance, covering 87% total population. Cases were defined persons at least one documented diagnosis depression (ICD-10-GM codes: F32, F33 or...
General obesity, as reflected by BMI, is an established risk factor for esophageal adenocarcinoma (EAC), a suspected gastric cardia (GCC) and appears unrelated to non-cardia (GNCC). How abdominal commonly measured waist circumference (WC), relates these cancers remains largely unexplored. Using anthropometric data from 391,456 individuals the European Prospective Investigation into Cancer Nutrition (EPIC) study 11 years of follow-up, we comprehensively assessed association measures with EAC,...
Abstract Background: Increasing evidence suggests that general obesity [measured by body mass index (BMI)] is positively associated with risk of esophageal adenocarcinoma (EAC). In contrast, previous studies have shown inverse relations squamous cell carcinoma (ESCC). However, it still unclear whether fat distribution, particularly abdominal obesity, each type cancer. Methods: We applied multivariable adjusted Cox proportional hazards regression to investigate the association between...
Given the recognized health effects of visceral fat, understanding how diet can modulate changes in phenotype "waist circumference for a given body mass index (WC(BMI))", proxy measure adiposity, is deemed necessary. Hence, objective present study was to assess association between dietary factors and prospective adiposity as measured by WC(BMI).We analyzed data from 48,631 men women 5 countries participating European Prospective Investigation into Cancer Nutrition (EPIC) study....
Risk models for lung cancer incidence would be useful prioritizing individuals screening and participation in clinical trials of chemoprevention. We present a risk model built using prospective cohort data from general population which predicts individual given time period. build separate current former smokers 169,035 ever the multicenter European Prospective Investigation into Cancer Nutrition (EPIC) considered never smokers. The set was split independent training test sets. Lung modeled...
Abstract Background To examine the association of education with body mass index (BMI) and waist circumference (WC) in European Prospective Investigation into Cancer Nutrition (EPIC). Method This study included 141,230 male 336,637 female EPIC-participants, who were recruited between 1992 2000. Education, which was assessed by questionnaire, classified four categories; BMI WC, measured trained personnel most participating centers, modeled as continuous dependent variables. Associations...
The relationship between body size and prostate cancer risk, in particular risk by tumour characteristics, is not clear because most studies have differentiated high-grade or advanced stage tumours, but rather assessed with a combined category of aggressive disease. We investigated the association height adiposity incidence death from 141,896 men European Prospective Investigation into Cancer Nutrition (EPIC) cohort. Multivariable-adjusted Cox proportional hazards models were used to...
Earlier epidemiological studies indicate that associations between obesity and breast cancer risk may not only depend on menopausal status use of exogenous hormones, but might also differ by tumor subtype. Here, we evaluated whether is differentially associated with the subtypes, as defined 6 immunohistochemical markers (ER, PR, HER2, Ki67, Bcl-2 p53, separately combined), in prospective EPIC-Germany Study (n = 27,012). Formalin-fixed paraffin-embedded (FFPE) tissues 657 incident cases were...