Giovanna Masala
A5058149593- Nutritional Studies and Diet
- Cancer Risks and Factors
- Obesity, Physical Activity, Diet
- Diet and metabolism studies
- Consumer Attitudes and Food Labeling
- BRCA gene mutations in cancer
- Nutrition, Genetics, and Disease
- Cancer, Lipids, and Metabolism
- Exercise and Physiological Responses
- Colorectal Cancer Screening and Detection
- Ovarian cancer diagnosis and treatment
- Helicobacter pylori-related gastroenterology studies
- thermodynamics and calorimetric analyses
- Lymphoma Diagnosis and Treatment
- Nutrition and Health in Aging
- Male Breast Health Studies
- Genetic factors in colorectal cancer
- Metabolism, Diabetes, and Cancer
- Microscopic Colitis
- Inflammatory Bowel Disease
- Global Cancer Incidence and Screening
- Metabolomics and Mass Spectrometry Studies
- Fatty Acid Research and Health
- Epigenetics and DNA Methylation
- Liver Disease Diagnosis and Treatment
Piedmont Reference Center for Epidemiology and Cancer Prevention
2016-2025
Istituto Zooprofilattico Sperimentale della Sardegna
2008-2025
Istituto per lo Studio e la Prevenzione Oncologica
2011-2024
Hudson Institute
2024
Prevention Institute
2010-2024
Utrecht University
2024
Regional Health
2024
Liechtenstein Institute
2024
John Wiley & Sons (United States)
2024
University of Cambridge
2021-2023
Abstract Aims The aim of this study was to develop, validate, and illustrate an updated prediction model (SCORE2) estimate 10-year fatal non-fatal cardiovascular disease (CVD) risk in individuals without previous CVD or diabetes aged 40–69 years Europe. Methods results We derived models using individual-participant data from 45 cohorts 13 countries (677 684 individuals, 30 121 events). used sex-specific competing risk-adjusted models, including age, smoking status, systolic blood pressure,...
<h3>Abstract</h3> <b>Objective</b> To examine whether adherence to the modified Mediterranean diet, in which unsaturates were substituted for monounsaturates, is associated with longer life expectancy among elderly Europeans. <b>Design</b> Multicentre, prospective cohort study. <b>Setting</b> Nine European countries (Denmark, France, Germany, Greece, Italy, Netherlands, Spain, Sweden, United Kingdom). <b>Participants</b> 74 607 men and women, aged 60 or more, without coronary heart disease,...
Abstract Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies; however, it is unknown if these associations are causal or confounded. In two-sample Mendelian randomisation analyses, using summary genetic data from the UK Biobank GWA consortia, we found that a one standard deviation increment average acceleration was (odds ratio [OR]: 0.51, 95% confidence interval [CI]: 0.27 to 0.98, P-value = 0.04) (OR: 0.66, CI: 0.48 0.90, 0.01)....
Human papillomavirus type 16 (HPV16) infection is causing an increasing number of oropharyngeal cancers in the United States and Europe. The aim our study was to investigate whether HPV antibodies are associated with head neck cancer risk when measured prediagnostic sera.We identified 638 participants incident (patients; 180 oral cancers, 135 oropharynx 247 hypopharynx/larynx cancers) 300 patients esophageal as well 1,599 comparable controls from within European Prospective Investigation...
The association between increasing body mass index (BMI; calculated as weight in kilograms divided by height meters squared) and risk of breast cancer is unique epidemiology that a crossover effect exists, with reduction before increase after menopause. inverse premenopausal poorly characterized but might be important the understanding causation.
Specific nutrients or foods have been inconsistently associated with ulcerative colitis (UC) Crohn's disease (CD) risks. Thus, we investigated associations between diet as a whole, dietary patterns, and UC CD Within the prospective EPIC (European Prospective Investigation into Cancer) study, set up nested matched case–control study among 366,351 participants inflammatory bowel data, including 256 incident cases of 117 CD, 4 controls per case. Dietary intake was recorded at baseline from...
Background In addition to HPV, high parity and hormonal contraceptives have been associated with cervical cancer (CC). However, most of the evidence comes from retrospective case-control studies. The aim this study is prospectively evaluate associations between factors risk developing intraepithelial neoplasia grade 3 (CIN3)/carcinoma in situ (CIS) invasive (ICC). Methods Findings We followed a cohort 308,036 women recruited European Prospective Investigation into Cancer Nutrition (EPIC)...
BackgroundRandomised trials of vitamin D supplementation for cardiovascular disease and all-cause mortality have generally reported null findings. However, generalisability results to individuals with low status is unclear. We aimed characterise dose-response relationships between 25-hydroxyvitamin (25[OH]D) concentrations risk coronary heart disease, stroke, in observational Mendelian randomisation frameworks.MethodsObservational analyses were undertaken using data from 33 prospective...
Abstract Objective To investigate the association of plasma vitamin C and carotenoids, as indicators fruit vegetable intake, with risk type 2 diabetes. Design Prospective case-cohort study. Setting Populations from eight European countries. Participants 9754 participants incident diabetes, a subcohort 13 662 individuals Investigation into Cancer Nutrition (EPIC) cohort 340 234 participants: EPIC-InterAct Main outcome measure Incident Results In multivariable adjusted model, higher was...
Several biomarkers of healthy aging have been proposed in recent years, including the epigenetic clocks, based on DNA methylation (DNAm) measures, which are getting increasingly accurate predicting individual biological age. The recently developed "next-generation clock" DNAmGrimAge outperforms "first-generation clocks" longevity and onset many age-related pathological conditions diseases. Additionally, total number stochastic mutations (SEMs), also known as mutation load (EML), has a...
It is currently unknown whether ultra-processed foods (UPFs) consumption associated with a higher incidence of multimorbidity. We examined the relationship total and subgroup UPFs risk multimorbidity defined as co-occurrence at least two chronic diseases in an individual among first cancer any site, cardiovascular disease, type 2 diabetes.
BackgroundUnhealthy diets, the rise of non-communicable diseases, and declining health planet are highly intertwined, where food production consumption major drivers increases in greenhouse gas emissions, substantial land use, adverse such as cancer mortality. To assess potential co-benefits from shifting to more sustainable we aimed investigate associations dietary emissions use with all-cause cause-specific mortality incidence rates.MethodsUsing data 443 991 participants European...
Association between dietary factors and the risk of developing inflammatory bowel disease (IBD) has been studied extensively. However, identification deleterious patterns merits further study. To investigate Crohn's (CD) ulcerative colitis (UC) according to score diet (ISD) in multinational European Prospective Investigation into Cancer Nutrition (EPIC) cohort. We used validated food frequency questionnaires collected at baseline compute ISD scores. estimated association risks CD UC using...
Abstract Alcohol consumption may be associated with risk of colorectal cancer (CRC), but the epidemiological evidence for an association specific anatomical subsites, types alcoholic beverages and current vs. lifetime alcohol intake is inconsistent. Within European Prospective Investigation into Cancer Nutrition (EPIC), 478,732 study subjects free at enrolment between 1992 2000 were followed up average 6.2 years, during which 1,833 CRC cases observed. Detailed information on baseline (all...
It is well established that parity and use of oral contraceptives reduce the risk ovarian cancer, but associations with other reproductive variables are less clear. We examined contraceptive factors cancer in European Prospective Investigation into Cancer Nutrition. Among 327 396 eligible women, 878 developed over an average 9 years. Hazard ratios (HRs) 95% confidence intervals (CIs) were estimated using Cox proportional hazard models stratified by centre age, adjusted for smoking status,...
To compare the average out-of-home (OH) consumption of foods and beverages, as well energy intake, among populations from 10 European countries to describe characteristics substantial OH eaters, defined for purpose present study, in comparison other individuals.Cross-sectional study. Dietary data were collected through single 24-hour dietary recalls, which place was recorded. For eaters those who consumed more than 25% total daily intake at locations household premises. Mean intakes...