Guillem Pera
A5048918534- Peripheral Artery Disease Management
- Liver Disease Diagnosis and Treatment
- Cerebrovascular and Carotid Artery Diseases
- Nutritional Studies and Diet
- Cardiovascular Health and Disease Prevention
- Alcohol Consumption and Health Effects
- Diet, Metabolism, and Disease
- Venous Thromboembolism Diagnosis and Management
- Diagnosis and Treatment of Venous Diseases
- Helicobacter pylori-related gastroenterology studies
- Gastric Cancer Management and Outcomes
- Blood Pressure and Hypertension Studies
- Obesity, Physical Activity, Diet
- Cancer Genomics and Diagnostics
- Hepatitis B Virus Studies
- Physical Activity and Health
- Liver Diseases and Immunity
- Cancer Risks and Factors
- Esophageal Cancer Research and Treatment
- Cardiac Health and Mental Health
- Health and Lifestyle Studies
- Diabetic Foot Ulcer Assessment and Management
- Liver Disease and Transplantation
- Nutrition and Health in Aging
- Acute Ischemic Stroke Management
Transports Metropolitans de Barcelona (Spain)
2023-2025
Institut Universitari d'Investigació en Atenció Primària Jordi Gol
2015-2024
Institut Català de la Salut
2010-2022
Hospital Universitari Germans Trias i Pujol
2022
Universitat de Barcelona
2013-2022
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2022
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2014-2022
Universitat de Girona
2022
Primary HealthCare
2009-2020
Xavier University
2018
<h3>Abstract</h3> <b>Objective</b> To examine whether adherence to the modified Mediterranean diet, in which unsaturates were substituted for monounsaturates, is associated with longer life expectancy among elderly Europeans. <b>Design</b> Multicentre, prospective cohort study. <b>Setting</b> Nine European countries (Denmark, France, Germany, Greece, Italy, Netherlands, Spain, Sweden, United Kingdom). <b>Participants</b> 74 607 men and women, aged 60 or more, without coronary heart disease,...
The evidence for anthropometric factors influencing breast cancer risk is accumulating, but uncertainties remain concerning the role of fat distribution and potential effect modifiers. We used data from 73,542 premenopausal 103,344 postmenopausal women 9 European countries, taking part in EPIC study. RRs Cox regression models were calculated, using measured height, weight, BMI waist hip circumferences; categorized by cohort-wide quintiles; expressed as continuous variables, adjusted study...
Dietary factors are thought to have an important role in gastric and esophageal carcinogenesis, but evidence from cohort studies for such a is lacking. We examined the risks of cancer adenocarcinoma associated with meat consumption within European Prospective Investigation Into Cancer Nutrition (EPIC) cohort.A total 521,457 men women aged 35-70 years 10 countries participated EPIC cohort. lifestyle information was collected at recruitment. Cox proportional hazard models were used examine...
It is considered that fruit and vegetable (F&V) protect against oesophagus gastric cancer (GC). However, 2 recent meta-analyses suggest the strength of association on GC seems to be weaker for vegetables than in cohort case-control studies. No evidence exists from studies about adenocarcinoma (ACO). In 521,457 men women participating EPIC 10 European countries, information diet lifestyle was collected at baseline. After an average 6.5 years follow-up, a total 330 65 ACO, confirmed classified...
Background & AimsLiver fibrosis is the main determinant of long-term outcome in chronic liver diseases. Little known about prevalence general population. The aim study was to investigate adult population with unknown disease.MethodsThis a population-based, cross-sectional performed Barcelona metropolitan area. Subjects aged 18 75 years old were identified randomly from citizens included primary health care registry. Of 4866 subjects invited, 3076 participated (63.2%). Liver estimated by...
Fibrosis-4 (FIB-4) and the nonalcoholic fatty liver disease fibrosis score (NFS) are 2 most popular noninvasive blood-based serum tests proposed for widespread screening. We therefore aimed to describe accuracy of FIB-4 NFS detect elevated stiffness as an indicator hepatic in low-prevalence populations.This study included a total 5129 patients with concomitant measurement FIB-4, NFS, (LSM) by Fibroscan (Echosens, France) from 5 independent population-based cohorts Spain, Hong Kong, Denmark,...
Abstract Smoking has recently been recognised as causally associated with the development of gastric cancer (GC). However, evidence on effect by sex, duration and intensity smoking, anatomic subsite cessation smoking is limited. Our objective was to assess relation between tobacco use GC incidence in European Prospective Investigation into Cancer Nutrition (EPIC). We studied data from 521,468 individuals recruited 10 countries taking part EPIC study. Participants completed lifestyle...
Epidemiological data show that reproductive and hormonal factors are involved in the etiology of endometrial cancer, but there is little on association with endogenous sex hormone levels. We analyzed between prediagnostic serum concentrations steroids cancer risk European Prospective Investigation into Cancer Nutrition using a nested case–control design 247 incident cases 481 controls, matched center, menopausal status, age, variables relating to blood collection, and, for premenopausal...
Environmental carcinogens contained in air pollution, such as polycyclic aromatic hydrocarbons, amines or N -nitroso compounds, predominantly form DNA adducts but can also generate interstrand cross-links and reactive oxygen species. If unrepaired, lesions increase the risk of somatic mutations cancer. Our study investigated relationships between 22 polymorphisms (and their haplotypes) 16 repair genes belonging to different pathways 1094 controls 567 cancer cases (bladder cancer, 131; lung...
Background/aims The prevalence of nonalcoholic fatty liver disease (NAFLD) is unknown in Spain. purpose detecting NAFLD patients to determine the associated factors and prevent its evolution more severe forms. aim this study with NAFLD. Methods This a multicentre, cross-sectional, populational study. Individuals between 15 85 years age were randomly selected from 25 primary healthcare centres province Barcelona, Clinical histories reviewed, anamnesis, physical examination, blood analysis...
The early diagnosis of atherosclerotic disease is essential for developing preventive strategies in populations at high risk and acting when the still asymptomatic. A low ankle-arm index a good marker vascular events may be diminished without presenting symptomatology (silent peripheral arterial disease). aim study to know prevalence associated factors general population. We performed cross-sectional, multicentre, population-based 3786 individuals >49 years, randomly selected 28 primary care...
The risk of gastric cancer (GC) associated with dietary intake nitrosodimethylamine (NDMA) and endogenous formation nitroso compounds (NOCs) was investigated in the European Prospective Investigation into Cancer Nutrition (EPIC). study included 521 457 individuals 314 incident cases GC that had occurred after 6.6 average years follow-up. An index NOC (ENOC) estimated using data iron content from meat faecal apparent total according to previous published studies. Antibodies Helicobacter...
Abstract In cancer patients, plasma often contains mutant DNA released by cells. We have assessed the significance of mutations for subsequent development in healthy subjects a large longitudinal prospective study. The European Prospective Investigation into Cancer and Nutrition study was analyzed with nested case-control design. Cases were nonsmokers or ex-smokers &gt;10 years newly diagnosed lung, bladder, upper aerodigestive tract cancers leukemia accrued after median follow-up 6.3...
Vitamin C is an antioxidant and inhibitor of carcinogenic N -nitroso compound production in the stomach. Higher dietary vitamin consumption associated with decreased risk gastric cancer (GC) numerous case–control studies, but data from prospective studies are limited, particularly so for blood measures C. The objective this study was to determine association plasma levels GC a nested within European Prospective Investigation into Cancer Nutrition (EPIC), large cohort involving 10 countries....
Despite declining incidence rates, gastric cancer (GC) is a major cause of death worldwide. Its aetiology may involve dietary antioxidant micronutrients such as carotenoids and tocopherols. The objective this study was to determine the association plasma levels seven common carotenoids, their total concentration, retinol α- γ-tocopherol, with risk adenocarcinoma in case–control nested within European Prospective Investigation into Cancer Nutrition (EPIC), large cohort involving 10 countries....
Insulin-like growth factor I (IGF-I) stimulates cell proliferation and can enhance the development of tumours in different organs. Epidemiological studies have shown that an elevated level circulating IGF-I is associated with increased risk breast cancer, as well other cancers. Most bound to acid-labile subunit one six insulin-like binding proteins (IGFBPs), among which most important are IGFBP-3 IGFBP-1. Polymorphisms IGF1 gene genes encoding for major carriers may predict levels impact on...
Helicobacter pylori (H. pylori), atrophic gastritis, dietary and life-style factors have been associated with gastric cancer (GC). These evaluated in a large case-control study nested the European Prospective Investigation into Cancer Nutrition carried out 9 countries, including Mediterranean area. Participants, enrolled 1992-1998, provided information blood sample (360,000; mean follow-up: 6.1 years). For 233 GC cases diagnosed after enrolment their 910 controls individually-matched by...
Background International multicentre studies on diet and cancer are relatively new in epidemiological research. They offer a series of challenging methodological issues for the evaluation association between dietary exposure disease outcomes, which can both be quite heterogeneous across different geographical regions. This requires considerable work to standardize measurements at food nutrient levels. Methods Within European Prospective Investigation into Cancer Nutrition (EPIC), calibration...