Jordi Gratacós‐Ginès
A5014936229- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Alcohol Consumption and Health Effects
- Drug-Induced Hepatotoxicity and Protection
- Liver Diseases and Immunity
- Hepatitis Viruses Studies and Epidemiology
- Acute Kidney Injury Research
- SARS-CoV-2 and COVID-19 Research
- Diet, Metabolism, and Disease
- Esophageal Cancer Research and Treatment
- Organ Transplantation Techniques and Outcomes
- COVID-19 Clinical Research Studies
- Microbial metabolism and enzyme function
- Pancreatic and Hepatic Oncology Research
- Gastric Cancer Management and Outcomes
- Helicobacter pylori-related gastroenterology studies
- Metastasis and carcinoma case studies
- COVID-19 Impact on Reproduction
- Alcoholism and Thiamine Deficiency
- Gastroesophageal reflux and treatments
- Abdominal vascular conditions and treatments
- Foreign Body Medical Cases
- Long-Term Effects of COVID-19
- Poisoning and overdose treatments
- Neurological diseases and metabolism
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2019-2025
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2019-2025
Hospital Clínic de Barcelona
2018-2025
Universitat de Barcelona
2020-2024
Pontificia Universidad Católica de Chile
2022
Centro de Investigación Biomédica en Red
2022
Institut Català de la Salut
2022
•The European Association for the Study of Liver published an algorithm diagnosis/management acute kidney injury in patients with cirrhosis. •This had not been validated real practice thus far. •In this prospective cohort study, use was associated high renal response rates, both overall and different phenotypes. resulted swift diagnosis treatment hepatorenal syndrome. •These results support clinical practice. Background Aims The management (AKI) cirrhosis is challenging. EASL guidelines...
•Around 9% of patients with alcohol-related cirrhosis are delisted for improvement.•MELD score is the main determinant improvement.•Women have higher probabilities being improvement.•Outcomes after delisting globally favorable and affected by alcohol relapse. Background & AimsTo what extent decompensated can improve until recovery from decompensation remains unclear. We aimed to investigate probability due improvement in on waiting list (WL) liver transplantation (LT).MethodsWe conducted a...
Infection by severe acute respiratory syndrome coronavirus-2 can induce uncontrolled systemic inflammation and multiple organ failure. The aim of this study was to evaluate if plasma exchange, through the removal circulating mediators, be used as rescue therapy in these patients.Single center case series.Local study.Four critically ill adults with coronavirus disease 19 pneumonia that failed conventional interventions.Plasma exchange. Two six sessions (1.2 volumes). Human albumin (5%) main...
Abstract Background The development of liver cirrhosis is usually an asymptomatic process until late stages when complications occur. potential reversibility the disease dependent on early diagnosis fibrosis and timely targeted treatment. Recently, use non-invasive tools has been suggested for screening fibrosis, especially in subjects with risk factors chronic disease. Nevertheless, large population-based studies cost-effectiveness analyses are still lacking to support widespread such...
Individuals with alcohol use disorder (AUD) are at risk of liver disease. There is scarce information on the effectiveness screening for fibrosis consumption. Thus, we evaluated efficacy a program consumption in individuals AUD.
Abstract Background and aims Alcohol metabolic syndrome (MS) coexist frequently as cofactors of liver disease. Previous studies suggest a deleterious effect MS in advanced alcohol‐related disease (ArLD). However, it is unknow whether can increase the risk fibrosis early stages ArLD. The aim this study was to investigate on subjects with alcohol consumption from population‐based cohort. Methods number include 1760(58%) 3014 who were randomly selected community consumed classified current...
Importance There are no useful treatments to prevent the development of severe complications liver cirrhosis. Simvastatin and rifaximin have shown beneficial effects in Objective To assess whether simvastatin combined with improves outcomes patients decompensated Design, Setting, Participants Double-blind, placebo-controlled, phase 3 trial conducted among cirrhosis 14 European hospitals between January 2019 December 2022. The last date follow-up was Interventions Patients were randomly...
Early forms of alcohol-associated liver disease (ALD) include different stages in the progression compensated ranging from steatosis to steatohepatitis and fibrosis. ALD has been classically diagnosed at advanced more frequently than other diseases. This fact probably contributed scarcity studies on early ALD. Recent have investigated prevalence general population described natural history alcohol-induced fibrosis, which linked worse prognosis compared chronic In addition, screening...
Impairment of kidney function is common in acute-on-chronic liver failure (ACLF). Patterns dysfunction and their impact on patient outcomes are ill-defined. Aims the current study were to investigate patterns patients with acute decompensation (AD) cirrhosis, or without ACLF. This prospective includes 639 admissions for AD (232 ACLF; 407 without) 518 patients. Data collected at admission during hospitalization, followed up 3 months. Urine samples analyzed biomarkers. Most ACLF (92%) had...
INTRODUCTION Statins are a group of molecules that inhibit the activity hydroxymethylglutaryl (HMG-CoA) reductase, lowering cholesterol levels. Besides their lipid-lowering effect, statins have also shown pleiotropic effects such as anti-inflammatory, antioxidative, and antiproliferative1(Fig. 1), thus being promising therapeutic option for treatment many chronic diseases, including liver diseases (CLD). In last 10 years, once concerns about safety in patients with impaired function been...
The value of noninvasive tools in the diagnosis autoimmune hepatitis (AIH)–related cirrhosis and prediction clinical outcomes is largely unknown. We sought to evaluate (1) utility liver stiffness measurement (LSM) (2) performance Sixth Baveno Consensus on Portal Hypertension (Baveno VI), expanded VI, ANTICIPATE models predicting absence varices needing treatment (VNT). A multicenter cohort 132 patients with AIH‐related was retrospectively analyzed. LSM endoscopies performed at time were...
Background and Aims: Alcohol-related liver disease (ALD) is a leading cause of liver-related mortality worldwide, with limited treatment options beyond abstinence transplantation. Chronic alcohol consumption has been linked to magnesium (Mg 2+ ) deficiency, which can influence the progression. The mechanisms underlying Mg homeostasis dysregulation in ALD remain elusive. This study aimed investigate role transporter Cyclin M4 (CNNM4) by analyzing its expression patterns patients preclinical...
Abstract Whether tubular injury develops in patients with acute kidney owing to hepatorenal syndrome (AKI‐HRS) is controversial. We performed repeated measurements of biomarkers during a 14‐day period 60 cirrhosis and AKI (34 AKI‐HRS meeting the classical definition type 1 HRS 26 necrosis, AKI‐ATN). Nineteen 34 had resolution AKI‐HRS, while remainder persistent AKI‐HRS. The persistence was associated remarkably high short‐term mortality. There were no significant differences urinary NGAL or...
Recent studies have found an increase in the seroprevalence of hepatitis E virus (HEV) infection patients with autoimmune (AIH). We aimed to assess prevalence positive anti-HEV IgM and IgG, HEV-RNA a cohort AIH, determine impact HEV serology on patient outcome, evaluate role hypergammaglobulinemia autoantibodies presence serology.One hundred five tested for between 2014 2018 were included study: 50 chronic AIH (more than 1 year treatment), 55 acute (30 25 non-AIH).Seroprevalence was higher...
Alcohol relapse after surviving an episode of alcohol-associated hepatitis (AH) is common. However, the clinical features, risk factors, and prognostic implications recurrent (RAH) are not well described.