Germán Soriano
A5034682808- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Drug-Induced Hepatotoxicity and Protection
- Organ Transplantation Techniques and Outcomes
- Hepatitis Viruses Studies and Epidemiology
- Electrolyte and hormonal disorders
- Abdominal vascular conditions and treatments
- Nutrition and Health in Aging
- Alcohol Consumption and Health Effects
- Viral gastroenteritis research and epidemiology
- Diet, Metabolism, and Disease
- Gut microbiota and health
- Drug Transport and Resistance Mechanisms
- Pharmacogenetics and Drug Metabolism
- Clinical Nutrition and Gastroenterology
- Renal function and acid-base balance
- Amoebic Infections and Treatments
- Pancreatitis Pathology and Treatment
- Systemic Sclerosis and Related Diseases
- Appendicitis Diagnosis and Management
- Genetic and Kidney Cyst Diseases
- Clostridium difficile and Clostridium perfringens research
- Gastrointestinal Bleeding Diagnosis and Treatment
- Probiotics and Fermented Foods
- Liver Diseases and Immunity
Hospital de Sant Pau
2016-2025
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2016-2025
Instituto de Salud Carlos III
2016-2025
Universitat Autònoma de Barcelona
2016-2025
Centro de Investigación Biomédica en Red
2009-2025
University of Miami
2024
Institut de Recerca Sant Pau
2024
University of Kansas Medical Center
2024
European Foundation for the Study of Chronic Liver Failure
2021
Centre for Biomedical Network Research on Rare Diseases
2020
In patients with cirrhosis and spontaneous bacterial peritonitis, renal function frequently becomes impaired. This impairment is probably related to a reduction in effective arterial blood volume associated high mortality rate. We conducted study determine whether plasma expansion intravenous albumin prevents reduces these patients.
Nitric oxide derived from vascular endothelium is a potent vasodilator that plays key role in the homeostasis of blood pressure. Because cirrhotic patients tend to have low arterial pressure, we measured 51 and 10 control subjects serum nitrite nitrate levels as an index vivo nitric generation. We also plasma endotoxin, substance frequently increased known induce synthesis. Cirrhotic showed significant increases nitrite/nitrate endotoxin compared with controls. Values were particularly...
•Patients with acutely decompensated cirrhosis without ACLF develop 3 different clinical courses.•Patients pre-ACLF within 90 days and have high systemic inflammation mortality.•Patients unstable suffer from complications of severe portal hypertension.•Patients stable less frequent lower 1-year mortality risk. Background & AimsAcute decompensation (AD) is defined as the acute development ascites, gastrointestinal hemorrhage, hepatic encephalopathy, infection or any combination thereof,...
Abstract Refractory hepatic encephalopathy (HE) remains a major cause of morbidity in cirrhosis patients. Large spontaneous portosystemic shunts (SPSSs) have been previously suggested to sustain HE these We aimed retrospectively assess the efficacy and safety patients treated with embolization large SPSSs for treatment chronic therapy-refractory European multicentric working group identify who may benefit from this procedure. Between July 1998 January 2012, 37 (Child A6-C13, MELD [Model...
Background & AimsWe investigated the effect of albumin treatment (20% solution) on hypoalbuminemia, cardiocirculatory dysfunction, portal hypertension, and systemic inflammation in patients with decompensated cirrhosis without bacterial infections.MethodsWe performed a prospective study to assess effects long-term (12 weeks) low doses (1 g/kg body weight every 2 high (1.5 week) serum albumin, plasma renin, function, pressure, levels cytokines, collecting data from 18 infections (the...
Acute decompensation (AD) of cirrhosis may present without acute-on-chronic liver failure (ACLF) (AD-No ACLF), or with ACLF (AD-ACLF), defined by organ failure(s). Herein, we aimed to analyze and characterize the precipitants leading both these AD phenotypes. The multicenter, prospective, observational PREDICT study (NCT03056612) included 1,273 non-electively hospitalized patients (No = 1,071; 202). Medical history, clinical data laboratory were collected at enrolment during 90-day...
Prospective drug-induced liver injury (DILI) registries are important sources of information on idiosyncratic DILI. We aimed to present a comprehensive analysis 843 patients with DILI enrolled into the Spanish Registry over 20-year time period.Cases were identified, diagnosed and followed prospectively. Clinical features, drug outcome data collected.A total patients, mean age 54 years (48% females), up 2018. Hepatocellular was associated younger (adjusted odds ratio [aOR] per year 0.983; 95%...
After an episode of acute bleeding from esophageal varices, patients are at high risk for recurrent and death. We compared two treatments to prevent — endoscopic ligation combined medical therapy with nadolol isosorbide mononitrate.
Patients who have bleeding from esophageal varices are at high risk for rebleeding and death. We compared the efficacy safety of endoscopic sclerotherapy with nadolol plus isosorbide mononitrate prevention variceal rebleeding.
Paracentesis–induced circulatory dysfunction (PICD) is a recently described complication that can be prevented with the administration of plasma expanders. The aim this study was to compare efficacy saline versus albumin in prevention PICD. Patients were randomized receive or after total paracentesis. readmitted as consequence second episode tense ascites treated paracentesis and alternative expander. After randomization, 35 patients received 37 albumin. Twenty–one for Significant increases...
Minimal hepatic encephalopathy (MHE) reduces quality of life and impacts daily functioning. It is known to impair fitness drive, but deficits in attention reaction may also be associated with falls. Falls have important consequences patients cirrhosis due coagulopathy, osteoporosis, operative risk. However, the relationship between MHE falls has not yet been evaluated. The objective this study retrospectively investigate whether cirrhosis.We included 130 cirrhotic outpatients 43 controls....
Cirrhotic patients with ascites and low ascitic fluid total protein and/or high serum bilirubin levels are at risk to develop the first episode of spontaneous bacterial peritonitis during long–term follow–up. The aim present study was determine efficacy continuous selective intestinal decontamination norfloxacin in prevention this complication. One hundred nine cirrhotic ≤ 1 g/dL or > 2.5 mg/dL without previous were prospectively randomized into two groups: group (n = 56) received...
Protein intake impacts on nutritional status and may determine the recurrence of hepatic encephalopathy (HE). A low-protein diet has been considered standard treatment after an episode HE, while branched-chain amino acids (BCAA) have shown to improve minimal HE. We performed a study investigate long-term effects supplementing protein-controlled with BCAA.A randomized, double-blind, multicenter that included 116 patients cirrhosis previous HE was conducted in four tertiary care hospitals. All...
Patients with cirrhosis often have functional limitations, decreased muscle mass, and a high risk of falls. These variables could improve exercise. The aim was to study the effects moderate exercise on capacity, body composition falls in patients cirrhosis. Twenty-three cirrhotic were randomized an programme (n = 14) or relaxation 9). Both programmes consisted one-hour session 3 days week for 12 weeks. At beginning end study, we measured capacity using cardiopulmonary test, evaluated...