Marco Pavesi
A5086126811- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Drug-Induced Hepatotoxicity and Protection
- Hepatitis Viruses Studies and Epidemiology
- Organ Transplantation Techniques and Outcomes
- Electrolyte and hormonal disorders
- Hepatitis C virus research
- Acute Myocardial Infarction Research
- Urinary Bladder and Prostate Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Hemodynamic Monitoring and Therapy
- Pelvic floor disorders treatments
- Lipoproteins and Cardiovascular Health
- Hepatitis B Virus Studies
- Heart Failure Treatment and Management
- Urinary Tract Infections Management
- Pulmonary Hypertension Research and Treatments
- Cardiovascular Syncope and Autonomic Disorders
- Acute Kidney Injury Research
- Eicosanoids and Hypertension Pharmacology
- Cardiac Health and Mental Health
- Radiopharmaceutical Chemistry and Applications
- Cardiac Imaging and Diagnostics
- Optimism, Hope, and Well-being
- Bone health and osteoporosis research
Ab Medica (Italy)
2024
IRCCS Istituto Auxologico Italiano
2023
European Foundation for the Study of Chronic Liver Failure
2013-2022
Office Of Health Economics
2021
Grifols (Spain)
2018-2020
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2010-2016
Canon (Japan)
2016
Hospital Clínic de Barcelona
2013-2015
Universitat de Barcelona
2010-2013
Instituto de Salud Carlos III
2013
Background —The aim of this study was to analyze 28-day case fatality trends between 1978 and 1993 among hospitalized acute myocardial infarction (AMI) patients in the REGICOR registry, Gerona, Spain, relate them thrombolytic antiplatelet drug use changes patient characteristics. Methods Results —A total 2053 consecutive 25 74 years age with a first Q-wave AMI admitted reference hospital were registered. Clinical characteristics management recorded. Four 4-year periods considered: 1981, 1982...
Acute-on-chronic liver failure (ACLF) in cirrhosis is characterized by acute decompensation (AD), organ failure(s), and high short-term mortality. Recently, we have proposed (systemic inflammation [SI] hypothesis) that ACLF the expression of an exacerbation SI already present decompensated cirrhosis. This study was aimed at testing this hypothesis included 522 patients with (237 ACLF) 40 healthy subjects. assessed measuring 29 cytokines redox state circulating albumin (HNA2), a marker...
Abstract Epidemiology, risk factors, and clinical effect of infections by multiresistant bacteria in cirrhosis are poorly known. This work was a prospective evaluation two series cirrhotic patients admitted with infection or developing during hospitalization. The first studied between 2005 2007 (507 bacterial 223 patients) the second 2010 2011 (162 110 patients). In series, 32% were community acquired (CA), healthcare associated (HCA), 36% nosocomial. Multiresistant (92 infections; 18%)...
Acute‐on‐chronic liver failure (ACLF) is characterized by acute decompensation (AD) of cirrhosis, organ failure(s), and high 28‐day mortality. We investigated whether assessments patients at specific time points predicted their need for transplantation (LT) or the potential futility care. assessed clinical courses 388 who had ACLF enrollment, from February through September 2011, during early (28‐day) follow‐up prospective multicenter European Chronic Liver Failure (CLIF) in Cirrhosis study....
Acute-on-chronic liver failure (ACLF) is a frequent cause of death in cirrhosis. Albumin dialysis with the molecular adsorbent recirculating system (MARS) decreases retained substances and improves hemodynamics hepatic encephalopathy (HE). However, its survival impact unknown. In all, 189 patients ACLF were randomized either to MARS (n=95) or standard therapy (SMT) (n=94). Ten (five per group) excluded due protocol violations. addition, 23 (MARS: 19; SMT: 4) from per-protocol (PP) analysis...
Bacterial infection is a frequent trigger of acute-on-chronic liver failure (ACLF), syndrome that could also increase the risk infection. This investigation evaluated prevalence and characteristics bacterial fungal infections causing complicating ACLF, predictors follow-up impact on survival. Patients 407 patients with ACLF 235 acute decompensation (AD). Results 152 (37%) presented at diagnosis; 46%(n=117) remaining 255 developed during (4 weeks). The corresponding figures in AD were 25% 18%...
•Patients with acutely decompensated cirrhosis without ACLF develop 3 different clinical courses.•Patients pre-ACLF within 90 days and have high systemic inflammation mortality.•Patients unstable suffer from complications of severe portal hypertension.•Patients stable less frequent lower 1-year mortality risk. Background & AimsAcute decompensation (AD) is defined as the acute development ascites, gastrointestinal hemorrhage, hepatic encephalopathy, infection or any combination thereof,...
Background & AimsWe investigated the effect of albumin treatment (20% solution) on hypoalbuminemia, cardiocirculatory dysfunction, portal hypertension, and systemic inflammation in patients with decompensated cirrhosis without bacterial infections.MethodsWe performed a prospective study to assess effects long-term (12 weeks) low doses (1 g/kg body weight every 2 high (1.5 week) serum albumin, plasma renin, function, pressure, levels cytokines, collecting data from 18 infections (the...
Acute decompensation (AD) of cirrhosis may present without acute-on-chronic liver failure (ACLF) (AD-No ACLF), or with ACLF (AD-ACLF), defined by organ failure(s). Herein, we aimed to analyze and characterize the precipitants leading both these AD phenotypes. The multicenter, prospective, observational PREDICT study (NCT03056612) included 1,273 non-electively hospitalized patients (No = 1,071; 202). Medical history, clinical data laboratory were collected at enrolment during 90-day...
Background: Patients with acutely decompensated cirrhosis (AD) may or not develop acute-on-chronic liver failure (ACLF). ACLF is characterized by high-grade systemic inflammation, organ failures (OF) and high short-term mortality. Although patients AD exhibit distinct clinical phenotypes at baseline, they have low mortality, unless develops during follow-up. Because little known about the association of profile inflammation cirrhosis, we aimed to investigate a battery markers in these...
•Variceal bleeding is frequently associated with ACLF in cirrhosis.•ACLF independently rebleeding and mortality.•Patients variceal can benefit from a pre-emptive (early) TIPS. Background & AimsThe relationship between acute-on-chronic liver failure (ACLF) acute (AVB) poorly understood. Specifically, the prevalence prognosis of context AVB unclear, while role transjugular intrahepatic portosystemic shunt (TIPS) management patients has not been described to date.MethodsA multicenter,...
•In a first-in-man, randomized-controlled trial of DIALIVE vs. standard care, the primary endpoint safety was met.•DIALIVE achieved acceptable performance characteristics for albumin exchange and reduction in endotoxin.•DIALIVE significantly reduced time to resolution ACLF improved prognostic scores compared with care.•DIALIVE had greater impact on pathophysiologically relevant biomarkers associated ACLF. Background & AimsAcute-on-chronic liver failure (ACLF) is characterized by severe...
STUDY OBJECTIVE: To establish the prevalence of main cardiovascular risk factors in province Gerona, where incidence myocardial infarction is known to be low. DESIGN: This was a cross sectional study conducted on large random population sample. SETTING: The Spain. PARTICIPANTS: Two thousand four hundred and eligible inhabitants Gerona aged between 25 74 years were randomly selected for multi-stage sample stratified by age sex. following standardly measured: lipids (total cholesterol, high...
Context.—Mortality after acute myocardial infarction is worse in women than men, even adjustment for comorbidity and age dissimilarities between sexes.Objective.—To assess the influence of sex on survival infarction.Design.—Inception cohort obtained a prospective registry patients with from 1992 through 1994.Setting.—Four teaching hospitals northeastern Spain.Patients.—All consecutive aged 80 years or younger first infarction. A total 331 1129 men were included.Main Outcome Measure.—Survival...
Abstract The diagnostic and prognostic criteria of acute-on-chronic liver failure (ACLF) were developed in patients with no Hepatitis B virus (HBV) cirrhosis (CANONIC study). aims this study to evaluate whether the (CLIF-C organ score; CLIF-C OFs) can be used classify patients; score ACLF score) could provide information HBV cirrhotic ACLF. 890 associated acute decompensation (AD) enrolled. Using OFs, 33.7% (300 patients) diagnosed as was more common younger those previous history...