Laure Elkrief
A5022659369- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Drug-Induced Hepatotoxicity and Protection
- Hepatitis Viruses Studies and Epidemiology
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Diseases and Immunity
- Abdominal vascular conditions and treatments
- Hepatitis C virus research
- Alcohol Consumption and Health Effects
- Hepatitis B Virus Studies
- Systemic Sclerosis and Related Diseases
- COVID-19 Clinical Research Studies
- Gastroesophageal reflux and treatments
- Amoebic Infections and Treatments
- Neurological Complications and Syndromes
- Diet, Metabolism, and Disease
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Telomeres, Telomerase, and Senescence
- Cannabis and Cannabinoid Research
- Pleural and Pulmonary Diseases
- Disaster Response and Management
- Organ Donation and Transplantation
- Extracellular vesicles in disease
- HIV/AIDS drug development and treatment
Centre Hospitalier Universitaire de Tours
2015-2025
Inserm
2013-2024
Université de Tours
2021-2024
Centre de Recherche sur l'Inflammation
2014-2024
Thion Medical (France)
2023-2024
Hôpital Beau-Séjour
2016-2024
Université Paris Cité
2012-2024
Fédération Hospitalo-Universitaire, Paris Center for Microbiome Medicine
2024
University Hospital of Geneva
2016-2022
Centre National de la Recherche Scientifique
2008-2022
Acute‐on‐chronic liver failure (ACLF) is characterized by acute decompensation (AD) of cirrhosis, organ failure(s), and high 28‐day mortality. We investigated whether assessments patients at specific time points predicted their need for transplantation (LT) or the potential futility care. assessed clinical courses 388 who had ACLF enrollment, from February through September 2011, during early (28‐day) follow‐up prospective multicenter European Chronic Liver Failure (CLIF) in Cirrhosis study....
•Patients with acutely decompensated cirrhosis without ACLF develop 3 different clinical courses.•Patients pre-ACLF within 90 days and have high systemic inflammation mortality.•Patients unstable suffer from complications of severe portal hypertension.•Patients stable less frequent lower 1-year mortality risk. Background & AimsAcute decompensation (AD) is defined as the acute development ascites, gastrointestinal hemorrhage, hepatic encephalopathy, infection or any combination thereof,...
To prospectively compare the technical success rate and accuracy of shear-wave elastography (SWE) transient (TE) for detection clinically significant portal hypertension (PH) in patients with advanced cirrhosis who are undergoing hepatic vein pressure gradient (HVPG) measurements.The institutional ethics committee approved study, written informed consent was obtained. Seventy-nine consecutive were SWE TE at time HVPG measurement studied. The compared diagnostic value liver stiffness (LS)...
Acute decompensation (AD) of cirrhosis may present without acute-on-chronic liver failure (ACLF) (AD-No ACLF), or with ACLF (AD-ACLF), defined by organ failure(s). Herein, we aimed to analyze and characterize the precipitants leading both these AD phenotypes. The multicenter, prospective, observational PREDICT study (NCT03056612) included 1,273 non-electively hospitalized patients (No = 1,071; 202). Medical history, clinical data laboratory were collected at enrolment during 90-day...
Abstract Background The burden and timeline of posttransplant infections are not comprehensively documented in the current era immunosuppression prophylaxis. Methods In this prospective study nested within Swiss Transplant Cohort Study (STCS), all clinically relevant were identified by transplant–infectious diseases physicians persons receiving solid organ transplant (SOT) between May 2008 December 2014 with ≥12 months follow-up. Results Among 3541 SOT recipients, 2761 (1612 kidney, 577...
Hepatitis C virus (HCV) envelope glycoproteins are highly glycosylated, with generally 4 and 11 N-linked glycans on E1 E2, respectively. Studies using mutated recombinant HCV incorporated into retroviral pseudoparticles (HCVpp) suggest that some play a role in protein folding, entry, protection against neutralization. The development of cell culture system producing infectious particles (HCVcc) hepatoma cells provides an opportunity to characterize the these context authentic virions. Here,...
In patients with chronic hepatitis C (CHC), cirrhosis is associated age, gender, diabetes, alcohol abuse, and coinfection human immunodeficiency virus (HIV) or B (HBV). The effect of these factors on the outcome unknown. This study in CHC aimed to assess influence decompensation, liver transplantation, death. Consecutive hospitalized between January 1, 2006 December 31, 2008 were followed up until death, closure March 2013. Gender, Model for End-Stage Liver Disease (MELD) score, HIV, HBV...
There is debate over the effects of long-term oral fluoroquinolone therapy in patients with advanced cirrhosis. We performed a randomized controlled trial to evaluate treatment norfloxacin on survival double-blind 291 Child-Pugh class C cirrhosis who had not received recent therapy. The study was at 18 clinical sites France from April 2010 through November 2014. Patients were randomly assigned groups given 400 mg (n = 144) or placebo 147) once daily for 6 months. evaluated monthly first...
Background and Aims Porto‐sinusoidal vascular liver disease (PSVD) is a rare cause of portal hypertension. PSVD still often misdiagnosed as cirrhosis, emphasizing the need to improve diagnosis strategies. Data on stiffness measurement using transient elastography (TE‐LSM) in are limited. The aim this study was evaluate accuracy TE‐LSM discriminate from cirrhosis patients with signs Approach Results Retrospective multicenter comparing PSVD, according Vascular Liver Disease Interest Group...
Assessing liver fibrosis is traditionally performed by biopsy, an imperfect gold standard. Non-invasive techniques, stiffness measurements (LSM) and biomarkers [FibroTest(R) (FT)], are widely used in countries where they available. The aim was to identify factors associated with LSM accuracy using FT as a non-invasive endpoint vice versa. proof of concept taken the manufacturers recommendations for excluding patients at high risk false negative/positive. hypothesis that concordance between...
The most serious complication of acute mesenteric vein thrombosis (MVT) is intestinal ischaemia requiring resection or causing death. Risk factors for this are unknown. To identify risk severe leading to in patients with MVT.We retrospectively analysed consecutive seen between 2002 and 2012 MVT 2 specialized units. Patients cirrhosis were excluded. We compared who required did not.Among 57 patients, a local factor was identified 14 (24%) oral contraceptive use 16 (29%), at least one more...