Klara M. Posfay‐Barbe
A5024739919- Respiratory viral infections research
- SARS-CoV-2 and COVID-19 Research
- Pneumonia and Respiratory Infections
- Streptococcal Infections and Treatments
- COVID-19 Clinical Research Studies
- Bacterial Infections and Vaccines
- Viral gastroenteritis research and epidemiology
- Vaccine Coverage and Hesitancy
- Neonatal and Maternal Infections
- Cytomegalovirus and herpesvirus research
- COVID-19 and Mental Health
- Herpesvirus Infections and Treatments
- Sepsis Diagnosis and Treatment
- Hepatitis B Virus Studies
- Immunodeficiency and Autoimmune Disorders
- Hepatitis Viruses Studies and Epidemiology
- Parvovirus B19 Infection Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- SARS-CoV-2 detection and testing
- Renal Transplantation Outcomes and Treatments
- Child and Adolescent Health
- Long-Term Effects of COVID-19
- Childhood Cancer Survivors' Quality of Life
- Pediatric health and respiratory diseases
- Influenza Virus Research Studies
University of Geneva
2016-2025
University Hospital of Geneva
2016-2025
Swiss HIV Cohort Study
2023-2025
Geneva College
2011-2024
Hôpital Beau-Séjour
2002-2024
University Hospital of Zurich
2022-2024
Office of Adolescent Health
2024
Swiss Finance Institute
2024
University of Zurich
2024
Hôpital de l'enfance
2008-2024
BackgroundAssessing the burden of COVID-19 on basis medically attended case numbers is suboptimal given its reliance testing strategy, changing definitions, and disease presentation. Population-based serosurveys measuring anti-severe acute respiratory syndrome coronavirus 2 (anti-SARS-CoV-2) antibodies provide one method for estimating infection rates monitoring progression epidemic. Here, we estimate weekly seroprevalence anti-SARS-CoV-2 in population Geneva, Switzerland, during...
Background. Nocardiosis is a rare, life-threatening opportunistic infection, affecting 0.04% to 3.5% of patients after solid organ transplant (SOT). The aim this study was identify risk factors for Nocardia infection SOT and describe the presentation nocardiosis in these patients.
Abstract Background The burden and timeline of posttransplant infections are not comprehensively documented in the current era immunosuppression prophylaxis. Methods In this prospective study nested within Swiss Transplant Cohort Study (STCS), all clinically relevant were identified by transplant–infectious diseases physicians persons receiving solid organ transplant (SOT) between May 2008 December 2014 with ≥12 months follow-up. Results Among 3541 SOT recipients, 2761 (1612 kidney, 577...
Hand hygiene promotion interventions rarely result in sustained improvement, and an assessment of their impact on individual infection risk has been lacking. We sought to measure the hand health care worker compliance care-associated among neonates.We conducted intervention study with a 9-month follow-up all workers at neonatal unit Children's Hospital, University Geneva Hospitals, between March 2001 February 2004. A multifaceted education program was introduced assessed during successive...
Significance Life-threatening susceptibility to common respiratory infections in previously healthy children can be indicative of pathogen-specific primary immunodeficiencies due rare deleterious variants key genes and pathways the immune system. These findings have implications for prevention treatment susceptible children.
To identify the determinants of antibody responses to adjuvanted split influenza A (H1N1) vaccines in patients with inflammatory rheumatic diseases.One hundred seventy-three (82 rheumatoid arthritis, 45 spondylarthritis, and 46 other diseases) 138 control subjects were enrolled this prospective single-center study. Controls received 1 dose A/09/H1N1 vaccine, 2 doses vaccine. Antibody measured by hemagglutination inhibition assay before 3-4 weeks after each dose. Geometric mean titers (GMTs)...
Abstract Next-generation sequencing has identified novel astroviruses for which a pathogenic role is not clearly defined. We astrovirus MLB2 infection in an immunocompetent case-patient and immunocompromised patient who experienced diverse clinical manifestations, notably, meningitis disseminated infection. The initial was by next-generation sequencing, revealed RNA cerebrospinal fluid, plasma, urine, anal swab specimens. then used specific real-time reverse transcription PCR to screen 943...
Varicella can have a severe course in immunosuppressed patients. Although prevention is fundamental, live-attenuated varicella-zoster (VZV) vaccine not currently recommended transplant recipients. Our aims were to (1) evaluate VZV immunity pediatric liver (LT) recipients; (2) immunize (two doses) seronegative patients post-LT; (3) monitor safety, (4) assess B and T cell responses. All followed at the Swiss National Pediatric LT Center approached 77/79 (97.5%) enrolled (median age 7.8 years)....
Summary In our study of 117 organ transplant recipients with nocardiosis, a history tumor, invasive fungal infection, donor age, and no acute rejection were independently associated 1-year mortality. Short-course antibiotic treatment (≤120 days), used in 17 patients, appeared promising.
Abstract Understanding the risk of infection from household- and community-exposures transmissibility asymptomatic infections is critical to SARS-CoV-2 control. Limited previous evidence based primarily on virologic testing, which disproportionately misses mild infections. Serologic measures are more likely capture all previously infected individuals. We apply household transmission models data a cross-sectional, household-based population serosurvey 4,534 people ≥5 years 2,267 households...
Respiratory syncytial virus (RSV) is associated with significant mortality rates amongst hematopoietic stem cell transplant (HSCT) recipients, less known about other immunocompromised patients. Ten-year retrospective cohort study of patients presenting RSV disease documented at University Hospitals Lausanne and Geneva. Severe RSV-related outcomes referred to respiratory conditions requiring hospital admission, as lower tract infection (LRTI) or pneumonia. We used multivariable logistic...
Abstract Growing evidence suggests receipt of live‐attenuated viral vaccines after solid organ transplant (SOT) has occurred and is safe needed due to lapses in herd immunity. A 2‐day consortium experts infectious diseases, transplantation, vaccinology, immunology was held with the objective review create expert recommendations for clinicians when considering live post‐SOT. For consideration VV MMR post‐transplant, exists only kidney liver recipients. vaccine post‐SOT, consider vaccination...
Abstract Background Assessing the burden of COVID-19 based on medically-attended case counts is suboptimal given its reliance testing strategy, changing definitions and wide spectrum disease presentation. Population-based serosurveys provide one avenue for estimating infection rates monitoring progression epidemic, overcoming many these limitations. Methods Taking advantage a pool adult participants from population-representative surveys conducted in Geneva, Switzerland, we implemented study...
Abstract Background Serological assays detecting anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies are being widely deployed in studies and clinical practice. However, the duration effectiveness of protection conferred by immune response remains to be assessed population-based samples. To estimate incidence newly acquired SARS-CoV-2 infections seropositive individuals as compared seronegative controls, we conducted a retrospective longitudinal matched study....
More than two years into the COVID-19 pandemic, most of population has developed anti-SARS-CoV-2 antibodies from infection and/or vaccination. However, public health decision-making is hindered by lack up-to-date and precise characterization immune landscape in population. Here, we estimated seroprevalence cross-variant neutralization capacity after Omicron became dominant Geneva, Switzerland.We conducted a population-based serosurvey between April 29 June 9, 2022, recruiting children adults...
The medium-term impact of the COVID-19 pandemic on wellbeing children and adolescents remains unclear. More than 2 years into pandemic, we aimed to quantify frequency determinants having been severely impacted by estimate its health-related quality life (HRQoL) mental health.
Vaccine responses are decreased in solid organ transplant (SOT) recipients, and given the complexity of implementation, vaccination programs may be suboptimal. The actual burden vaccine-preventable infections (VPIs) among SOT recipients remains unclear.To assess incidence rate VPIs to evaluate whether at increased risk for specific compared with general population.This nationwide cohort study used data from Swiss Transplant Cohort Study on individuals who underwent May 2008 June 2019...