Sven Hillinger
A5031740153- Transplantation: Methods and Outcomes
- Organ Transplantation Techniques and Outcomes
- Lung Cancer Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Pleural and Pulmonary Diseases
- Renal Transplantation Outcomes and Treatments
- Occupational and environmental lung diseases
- Mechanical Circulatory Support Devices
- Lung Cancer Treatments and Mutations
- Tracheal and airway disorders
- Advanced Proteomics Techniques and Applications
- Cardiac Ischemia and Reperfusion
- Immunotherapy and Immune Responses
- Medical Imaging and Pathology Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Radiomics and Machine Learning in Medical Imaging
- Pneumocystis jirovecii pneumonia detection and treatment
- Nitric Oxide and Endothelin Effects
- Chemokine receptors and signaling
- Medical Imaging Techniques and Applications
- Neuropeptides and Animal Physiology
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Organ and Tissue Transplantation Research
- Cell Adhesion Molecules Research
- Immune Cell Function and Interaction
Swiss HIV Cohort Study
2023-2025
University Hospital of Zurich
2015-2024
University of Zurich
2009-2023
Hôpital Beau-Séjour
2023
Financial Research (Hungary)
2023
University Hospital of Basel
2021-2022
National Taiwan University
2021
University Children's Hospital Zurich
2010
Suwon Research Institute
2010
Seoul National University
2007
Abstract Background The burden and timeline of posttransplant infections are not comprehensively documented in the current era immunosuppression prophylaxis. Methods In this prospective study nested within Swiss Transplant Cohort Study (STCS), all clinically relevant were identified by transplant–infectious diseases physicians persons receiving solid organ transplant (SOT) between May 2008 December 2014 with ≥12 months follow-up. Results Among 3541 SOT recipients, 2761 (1612 kidney, 577...
The oncological equivalence of anatomical segmentectomy for early stage non-small cell lung cancer (NSCLC) is still controversial. Primary aim this study was survival outcomes in combination with improved quality life after compared lobectomy patients pathological Ia NSCLC (up to 2 cm, 7th edition) MATERIALS AND METHODS: We conducted a prospective, randomized, multicenter phase III trial confirm the non-inferiority regard prognosis (trial No. DRKS00004897). Patients were randomized undergo...
Vaccine responses are decreased in solid organ transplant (SOT) recipients, and given the complexity of implementation, vaccination programs may be suboptimal. The actual burden vaccine-preventable infections (VPIs) among SOT recipients remains unclear.To assess incidence rate VPIs to evaluate whether at increased risk for specific compared with general population.This nationwide cohort study used data from Swiss Transplant Cohort Study on individuals who underwent May 2008 June 2019...
Importance Surgical site infections (SSIs) are one of the most common health care–associated infections. can have harmful effects in liver transplant (LT) recipients. Objective To assess incidence SSI after LT and identify risk factors associated with SSIs whether death graft loss. Design, Setting, Participants A multicenter cohort study encompassing data on performed at all Swiss centers between May 1, 2008, September 30, 2020, was conducted. Data analyses were 2023. Exposure Liver...
To achieve in situ tumor antigen uptake and presentation, intratumoral administration of ex vivo-generated, gene-modified murine bone marrow-derived dendritic cells (DC) was used a lung cancer model. attract mature host DC activated T at the site, were transduced with an adenoviral vector expressing secondary lymphoid tissue chemokine (CCL21/SLC). Sixty percent mice treated 10(6) DC-AdCCL21 intratumorally (7-10 ng/ml/10(6) cells/24 h CCL21) weekly intervals for 3 weeks showed complete...
Purpose: Anastomotic complications following lung transplantation (LuTx) have been described in up to 15% of patients. Challenging treat, they are associated with high morbidity and a mortality rate 2–5%. The aim this study was analyze the incidence consecutive series bronchial anastomosis after LuTx at our center delineate potential risk factors. Methods: Between 1992 2007, 441 anastomoses were performed 235 Indications for cystic fibrosis (35.7%) emphysema (28.1%) pulmonary (12.8%)...
Objective: Pulmonary sequestration is a rare congenital malformation and may be the cause of recurrent infections or hemoptysis. It has been shown in case reports that resection by video-assisted thoracic surgery (VATS) feasible despite possible technical difficulties due to inflammatory changes, but its role not evaluated yet larger series consecutively treated patients. Methods: Retrospective analysis all thoracoscopically patients (between January 1991 2005) with pulmonary single center....
BNT162b2 by Pfizer-BioNTech and mRNA-1273 Moderna are the most commonly used vaccines to prevent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. Head-to-head comparison of efficacy these in immunocompromised patients is lacking.Parallel, 2-arm (allocation 1:1), open-label, noninferiority randomized clinical trial nested into Swiss HIV Cohort Study Transplant Study. People living with human immunodeficiency virus (PLWH) or solid organ transplant recipients (SOTR; ie,...
Abstract Background The use of assays detecting cytomegalovirus (CMV)–specific T cell–mediated immunity may individualize the duration antiviral prophylaxis after transplantation. Methods In this randomized trial, kidney and liver transplant recipients from 6 centers in Switzerland were enrolled if they CMV-seronegative with seropositive donors or CMV-seropositive receiving antithymocyte globulins. Patients to a based on immune monitoring (intervention) fixed (control). control group planned...
There are limited contemporary data on the epidemiology and outcomes of bacteremia in solid organ transplant recipients (SOTr).Using Swiss Transplant Cohort Study registry from 2008 to 2019, we performed a retrospective nested multicenter cohort study describe SOTr during first year post-transplant.Of 4383 patients, 415 (9.5%) with 557 cases due 627 pathogens were identified. One-year incidence was 9.5%, 12.8%, 11.4%, 9.8%, 8.3%, 5.9% for all, heart, liver, lung, kidney, kidney-pancreas...
Minimal invasive surgical techniques have gained high acceptance in thoracic surgery during the last 10 years. However, up to now, only scant information exists on chronic postoperative pain and discomfort patients who underwent video-assisted thoracoscopy. Therefore, a retrospective study was performed with aid of self-reported questionnaire.Two hundred thirteen (of whom 79 females) mean age 48 (range 15-88) years were operated for total 225 procedures. Thoracoscopy pneumothorax (n=70),...
The aim of this study was to delineate the profile extended donor lungs in comparison ideal and analyse their outcome. Particular attention given with a low PaO(2) (<250mmHg) before harvesting or multiple criteria.Between 1993 2003, 148 patients (79 women, 69 men, mean age 39.9 years) underwent lung transplantation. Indications were cystic fibrosis 35.8%, emphysema 26.4%, pulmonary 12.2%, hypertension 9.5%, others 16.1%. Donor data recipients medical files reviewed. Criteria for considered...
Abstract The antitumor efficiency of dendritic cells transduced with an adenovirus vector expressing secondary lymphoid chemokine (CCL21) was evaluated in a murine model spontaneous bronchoalveolar cell carcinoma. transgenic mice (CC-10 TAg) express the SV40 large T antigen (TAg) under Clara promoter, develop bilateral, multifocal, and pulmonary adenocarcinomas, die at 4 months as result progressive tumor burden. A single intratracheal administration CCL21 gene-modified (DC-AdCCL21) led to...
Lobar lung transplantation is an option that provides the possibility of transplanting urgent listed recipient small size with a size-mismatched donor by surgically reducing lung. We report our short- and long-term results bilateral lobar (BLLT) compare it outcomes cohort. Retrospective analyses 75 transplant recipients who received downsized lungs special focus on 23 BLLT performed since January 2000. Postoperative surgical complications, function tests, late complications survival were...