A5010608356- Pneumocystis jirovecii pneumonia detection and treatment
- Transplantation: Methods and Outcomes
- Antifungal resistance and susceptibility
- Cytomegalovirus and herpesvirus research
- HIV/AIDS drug development and treatment
- Renal Transplantation Outcomes and Treatments
- Hepatitis C virus research
- HIV/AIDS Research and Interventions
- Fungal Infections and Studies
- COVID-19 Clinical Research Studies
- Hepatitis B Virus Studies
- Antibiotic Resistance in Bacteria
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Tuberculosis Research and Epidemiology
- Influenza Virus Research Studies
- Cerebrospinal fluid and hydrocephalus
- Antibiotics Pharmacokinetics and Efficacy
- Cardiac Arrest and Resuscitation
- Herpesvirus Infections and Treatments
- Cardiac Structural Anomalies and Repair
- SARS-CoV-2 and COVID-19 Research
- Mechanical Circulatory Support Devices
- Central Venous Catheters and Hemodialysis
- Metabolism and Genetic Disorders
- Pneumonia and Respiratory Infections
University Health Network
2022-2025
Toronto General Hospital
2022-2025
University of Toronto
2022-2025
University Hospital of Bern
2016-2025
University of Bern
2016-2025
University Hospital of Lausanne
2013
University of Basel
2013
University Hospital of Basel
2008
Data on infections associated with cerebrospinal fluid (CSF) shunts among adults are limited. Therefore, we performed a retrospective study of shunt-associated in adults.Patients aged > or = 12 years CSF and admitted to our institution(University Hospital Basel, Switzerland) from January 1996 through December 2006 were included retrospectively. charts reviewed, follow-up was by assessment later hospitalizations telephone contact patients, their families, general practitioners.Seventy-eight...
The cellular immune system is of pivotal importance with regard to the response severe infections. Monocytes/macrophages are considered key cells in infections and downregulation surface expression monocytic human leukocyte antigen-DR (mHLA-DR) within major histocompatibility complex class II reflects a state immunosuppression, also referred as injury-associated immunosuppression. As role immunosuppression coronavirus disease 2019 (COVID-19) currently unclear, we seek explore level mHLA-DR...
Vaccine responses are decreased in solid organ transplant (SOT) recipients, and given the complexity of implementation, vaccination programs may be suboptimal. The actual burden vaccine-preventable infections (VPIs) among SOT recipients remains unclear.To assess incidence rate VPIs to evaluate whether at increased risk for specific compared with general population.This nationwide cohort study used data from Swiss Transplant Cohort Study on individuals who underwent May 2008 June 2019...
Abstract Background The use of assays detecting cytomegalovirus (CMV)–specific T cell–mediated immunity may individualize the duration antiviral prophylaxis after transplantation. Methods In this randomized trial, kidney and liver transplant recipients from 6 centers in Switzerland were enrolled if they CMV-seronegative with seropositive donors or CMV-seropositive receiving antithymocyte globulins. Patients to a based on immune monitoring (intervention) fixed (control). control group planned...
In this study, we investigated the clinical impact of different urinary tract infection (UTI) phenotypes occurring within first year after renal transplantation. The population included 2368 transplantations having 2363 UTI events. Patients were categorized into four groups based on their compiled events observed transplantation: (i) no colonization or (n = 1404; 59%), (ii) only 353; 15%), (iii) occasional with 1-2 episodes 456; 19%), and (iv) recurrent ≥3 155; 7%). One-year mortality graft...
Posttransplant lymphoproliferative disorder (PTLD) is a serious complication of solid organ transplantation (SOT). Most PTLD cases are associated with Epstein-Barr virus (EBV) infection. The role antiviral prophylaxis or rituximab therapy for prevention in SOT recipients controversial. In nationwide cohort, we assessed the incidence, presentation, and outcome histologically proven PTLD. We included 4765 patients follow-up duration 23 807 person-years (py). Fifty-seven were identified; 39...
Abstract Ganciclovir (GCV)‐resistant cytomegalovirus (CMV) infection is a common problem among solid organ transplant (SOT) recipients without prior CMV immunity (CMV D+/R−). GCV‐resistant represents particular challenge for management. Letermovir recently licensed antiviral agent primary prophylaxis in allogenic hematopoietic stem cell (HSCT) recipients. Given the favorable safety profile and its oral bioavailability letermovir may be considered valuable off‐label option secondary of SOT...
To describe the epidemiology and clinical presentation of central nervous system (CNS) infections in solid organ transplant (SOT) recipients current era transplantation.Patients from Swiss Transplant Cohort Study (STCS) transplanted between 2008 2018 were included with a median follow-up 3.8 years. Epidemiological, microbiological, data extracted STCS database patients' medical records. We calculated incidence rates 90-day survival CNS infection.Among 4762 patients, 42 episodes infection 41...
In coronavirus disease-2019 (COVID-19) patients, there is increasing evidence of neuronal injury by the means elevated serum neurofilament light chain (sNfL) levels. However, role systemic inflammation and severe acute respiratory syndrome 2 (SARS-CoV-2)-specific immune response with regard to has not yet been investigated.In a prospective cohort study, we recruited patients mild-moderate (n = 39) 14) COVID-19 measured sNfL levels, cytokine concentrations, SARS-CoV-2-specific antibodies...
Abstract Background Hyperammonemia syndrome (HS) is a rare but potentially fatal complication of Lung Transplantation (LT). Optimal screening methods are unknown: Here we investigated serum ammonia (SAS) for HS and compared it with PCR Mollicutes (ureaplasma-producing bacteria). Methods All LT recipients from 07/2019-02/2020 10/2021-11/2022 available donor bronchial wash samples the biobank were included. Mollicute-PCR was performed using two commercially kits. Daily levels measured first 14...
Background Pneumocystis jirovecii pneumonia (PCP) is a frequent opportunistic infection in immunocompromised patients. In literature, presentation and outcome of PCP differs between patients with human immunodeficiency virus (HIV) renal transplant recipients (RTRs). Methods We conducted cross-sectional study based on the HIV registries at our institution. Radiological clinical data from all confirmed cases 2005 2012 were compared. Results Forty included: 16 24 RTRs. Radiologically, had...
Background: Whereas tenofovir disoproxil fumarate (TDF) can lead to renal adverse events, alafenamide (TAF) has a more favorable safety profile. However, the impact of replacing TDF with TAF on function and liver parameters among HIV/hepatitis B virus (HBV)-coinfected individuals dysfunction remains unclear. Methods: We included all participants from Swiss HIV Cohort Study an HIV/HBV coinfection who switched had estimated glomerular filtration rate (eGFR) <90 mL/min/1.73 m 2 suppressed...
Abstract Background The immunogenicity of the standard influenza vaccine is reduced in solid-organ transplant (SOT) recipients, so new vaccination strategies are needed this population. Methods Adult SOT recipients from 9 clinics Switzerland and Spain were enrolled if they &gt;3 months after transplantation. Patients randomized (1:1:1) to a MF59-adjuvanted or high-dose (intervention), (control), with stratification by organ time transplant. primary outcome was response rate, defined as...
This analysis of 116 isavuconazole therapy courses shows that hepatic test disturbances (HTDs) were relatively frequent (29% cases) but rarely led to treatment interruption (5%). Importantly, patients with baseline HTDs, including those attributed a first-line triazole, did not exhibit higher risk subsequent HTD under therapy.
Background. ABO-incompatible (ABOi) kidney transplantation (KT) expands the donor pool and may help to overcome organ shortage. Nonetheless, concerns about infectious complications associated with ABOi-KT have been raised. Methods. In a nationwide cohort (Swiss Transplant Cohort Study), we compared risk for among ABOi ABO-compatible (ABOc) renal transplant recipients. Infections needed fulfill rigorous, prespecified criteria be classified as clinically relevant. Unadjusted adjusted competing...
Fasciola hepatica is a foodborne trematode present worldwide. Definitive hosts are mostly ruminants such as cattle and sheep, well humans. In Switzerland, infection in humans rare. Unfortunately, many patients likely to undergo multiple unnecessary investigations before the parasite suspected fascioliasis diagnosed, especially if symptoms unspecific.Retrospective analysis of all diagnosed with at University Hospital Bern between 2005 2018. Diagnosis was positive serology and/or eggs stool...
Food-safety measures are recommended to solid organ transplant (SOT) recipients. However, the burden of foodborne infections in SOT recipients has not been established. We describe epidemiology and outcomes bacterial a nationwide cohort including 4405 Switzerland between 2008 2018. Participants were prospectively followed for median 4.2 years with systematic collection data on infections, patient graft-related outcomes. identified 151 episodes microbiologically confirmed occurring 1.6 (IQR...
Abstract Background Influenza‐associated pulmonary aspergillosis (IAPA) is an important complication of severe influenza with high morbidity and mortality. Methods We conducted a retrospective multicenter study in tertiary hospitals Switzerland during 2017/2018 2019/2020 seasons. All adults PCR‐confirmed infection treatment on intensive‐care unit (ICU) for >24 h were included. IAPA was diagnosed according to previously published clinical, radiological, microbiological criteria. assessed...