Judith Racapé
A5023072513- Migration, Health and Trauma
- Renal Transplantation Outcomes and Treatments
- Global Maternal and Child Health
- Health disparities and outcomes
- Organ Transplantation Techniques and Outcomes
- Food Security and Health in Diverse Populations
- Insect and Pesticide Research
- Healthcare Systems and Practices
- Transplantation: Methods and Outcomes
- COVID-19 and healthcare impacts
- Cytomegalovirus and herpesvirus research
- Reproductive Biology and Fertility
- Plant-Microbe Interactions and Immunity
- Non-Invasive Vital Sign Monitoring
- Legume Nitrogen Fixing Symbiosis
- Urinary Tract Infections Management
- Maternal and Perinatal Health Interventions
- Renal Diseases and Glomerulopathies
- Birth, Development, and Health
- COVID-19 and Mental Health
- Breastfeeding Practices and Influences
- COVID-19 Clinical Research Studies
- Child and Adolescent Health
- Migration, Identity, and Health
- COVID-19 Impact on Reproduction
Université Libre de Bruxelles
2016-2025
Erasmus Hospital
2011-2025
Directorate-General for Health and Food Safety
2025
Eurocontrol
2024
Institut Scientifique de Santé Publique
2011-2019
Statistics Belgium
2015
Mie University Hospital
2011-2013
Universitair Ziekenhuis Brussel
2011
Université Paris Cité
2006
Délégation Paris 5
2006
Background. Nocardiosis is a rare, life-threatening opportunistic infection, affecting 0.04% to 3.5% of patients after solid organ transplant (SOT). The aim this study was identify risk factors for Nocardia infection SOT and describe the presentation nocardiosis in these patients.
Summary In our study of 117 organ transplant recipients with nocardiosis, a history tumor, invasive fungal infection, donor age, and no acute rejection were independently associated 1-year mortality. Short-course antibiotic treatment (≤120 days), used in 17 patients, appeared promising.
Increasing studies show that immigrants have different perinatal health outcomes compared to native women. Nevertheless, we lack a systematic examination of the combined effects immigrant status and socioeconomic factors on outcomes. Our objectives were analyse national Belgian data determine 1) whether (SES) modifies association between maternal nationality (low birth weight mortality); 2) effect adopting foreign This study is population-based using from linked death certificates civil...
ObjectivesMany transplant physicians screen for and treat asymptomatic bacteriuria (ASB) during post-kidney-transplant surveillance. We investigated whether antibiotics are effective in reducing the occurrence of symptomatic urinary tract infection (UTI) kidney recipients with ASB.MethodsWe performed this multicentre, randomized, open-label trial who had ASB were ≥2 months post-transplantation. randomly assigned participants to receive or no therapy. The primary outcome was incidence UTI...
Summary Background and objectives In 2009, the pandemic influenza A/H1N1 accounted for worldwide recommendations about vaccination. There are few data concerning immunogenicity or security of adjuvanted-A/H1N1 vaccine in transplanted hemodialyzed patients. Design, setting, participants, & measurements Sera from 21 controls, 53 (HD) patients, 111 renal transplant recipients (RT) were sampled before (T0) 1 month after (T1) a single dose Pandemrix® (GSK Biologicals, AS03-adjuvanted). We...
Background. Although numerous risk factors for delayed graft function (DGF) have been identified, the role of ischemia-reperfusion injury and acute rejection episodes (ARE) occurring during DGF period is ill-defined impact on patient outcome remains controversial. Methods. From 1983 to 2014, 1784 kidney-only transplantations from deceased donors were studied. Classical along with two novel ones, recipient's perioperative saline loading residual diuresis, analyzed by logistic regression...
In contrast to angiotensin receptor blockers (ARBs), mainly excreted by the liver, dosage of angiotensin-converting enzyme (ACE) inhibitors, cleared kidney, must be adapted account for renal clearance in patients with chronic kidney disease (CKD) avoid acute injury (AKI). Community-acquired AKI and use ACE inhibitors or ARBs emergency department were retrospectively assessed 324 baseline stage 3 higher CKD. After stepwise regression analysis, (odds ratio [OR], 1.9; 95% confidence interval...
BackgroundKidney recipients maintaining a prolonged allograft survival in the absence of immunosuppressive drugs and without evidence rejection are supposed to be exceptional. The ERA-EDTA-DESCARTES working group together with Nantes University launched European-wide survey identify new patients, describe them estimate their frequency for first time.
Abstract Background Despite concerns about worsening pregnancy outcomes resulting from healthcare restrictions, economic difficulties and increased stress during the COVID-19 pandemic, preterm birth (PTB) rates declined in some countries 2020, while stillbirth appeared stable. Like other shocks, pandemic may have exacerbated existing socioeconomic disparities pregnancy, but this remains to be established. Our objective was investigate changes PTB by status (SES) European countries. Methods...
There are wide disparities in neonatal mortality rates (NMRs, deaths <28 days of life after live birth per 1000 births) between countries Europe, indicating potential for improvement. Comparing country-specific patterns births and with low can facilitate the development effective intervention strategies.
Major histocompatibility complex class 1 chain-related antigen A (MICA) antibodies (Abs) have been associated with renal graft loss in one large cohort. The triggering factors for MICA Abs and their autologous or allogeneic specificity not well defined. More data on the impact of grafts outcome are needed.We tested sera from 494 controls 597 patients chronic kidney disease (CKD) using Luminex. Forty CKD MICA+ were genotyped alleles to determine auto- allospecificity. We compared MICA-...
Acute renal rejection is a major risk factor for chronic allograft dysfunction and long-term graft loss. We performed genome-wide association study to detect loci associated with biopsy-proven acute T cell-mediated occurring in the first year after transplantation. In discovery cohort of 4127 European recipients transplanted eight centers, we used DNA pooling approach compare 275 cases 503 controls. an independent replication 2765 patients two countries, identified 313 531 controls, whom...
The prospective, randomized AHL2011 trial demonstrated that the use of doxorubicin, bleomycin, vinblastine, and dacarbazine regimen (ABVD) after two cycles etoposide, cyclophosphamide, vincristine, procarbazine, prednisone (BEACOPPescalated) in early responders on basis a positron emission tomography (PET)-driven strategy was safe minimized toxicity compared with standard 6 BEACOPPescalated cycles. This substudy investigated benefit this gonadal function fertility patients under 45 years...
To assess the effect of maternity unit characteristics on cesarean section (CS) rate, using Robson's Ten-Group Classification System (TGCS) and considering sociodemographic medical mother. The study, conducted in Belgium from 2011 to 2019, employed an analytical design utilizing a nationwide register routine data focused hospital births. CS rate was analyzed by neonatal intensive care (NICU) availability maternal size for TGCS groups 1, 2, 5, which were highest contributors total rate....
Background The association between migration and pregnancy outcomes gives contradictory results. Women’s socio-economic status explains some differences, but its influence may vary according to women’s underlying health conditions. Our aim was understand how comorbidities modify the relationship preterm birth or small for gestational age in Belgium. Methods Data are related all singleton births women living Belgium 2010 2019 (n = 1 200 417). Maternal nationalities were grouped as Belgium,...
A structural model of BgK, a sea anemone toxin, complexed with the S5-S6 region Kv1.1, voltage-gated potassium channel, was determined by flexible docking under distance restraints identified double mutant cycles approach. This structure provides molecular basis for identifying major determinants BgK-Kv1.1 channel interactions involving BgK dyad residues Lys(25) and Tyr(26). These are (i) electrostatic between extremity side chain carbonyl oxygen atoms from selectivity filter that may be...
The relation between immigration status and perinatal mortality is unclear. objective of this study to describe measure inequalities in causes deaths according maternal nationality socioeconomic status.A population-based cohort related all babies born during the period 1998-2006 whose mothers were living Brussels, irrespective place delivery. Perinatal post-perinatal analysed sociodemographic characteristics at birth. We used logistic regression estimate odds ratios (ORs) for association...
Background The impact of major histocompatibility class I chain-related A (MICA) antibodies on renal graft outcomes is unclear. goal this work was to assess the posttransplant MICA antibodies, assayed at 1 year, with two commercially available kits, long-term outcomes. Methods We retrospectively tested sera from 779 kidney transplant recipients single-antigen flow bead assays year after transplantation. Samples were considered positive for if they in both tests or specificities that present...
PopA is released by type III secretion from the bacterial plant pathogen Ralstonia solanacearum and triggers hypersensitive response (HR) in tobacco. The function of remains obscure, mainly because mutants lacking this protein are not altered their ability to interact with plants. In an attempt identify site activity cells, we generated transgenic tobacco plants expressing popA gene under control inducible promoter. Immunocytologic analysis revealed that HR phenotype these correlated...
The aim of our study was to evaluate the prevalence acquired thrombophilic factors in Stage V chronic kidney disease (CKD) patients according dialysis modality, rate correction these 1 month after renal transplantation and their impact on cardiovascular or thromboembolic events at year.Three hundred ten were prospectively screened for seven transplantation; 215 them also assayed after. All received prophylactic acetylsalicylic acid, started before transplantation.The significantly higher...
Primary microcephaly (PM) is characterized by a small head since birth and vastly heterogeneous both genetically phenotypically. While most cases are monogenic, genetic interactions between Aspm Wdr62 have recently been described in mouse model of PM. Here, we used two complementary, holistic vivo approaches: high throughput DNA sequencing multiple PM genes human patients with PM, genome-edited zebrafish modeling for the digenic inheritance Exomes showed significant burden variants 75 genes,...
Background Subgroups of precarious populations such as homeless people are more exposed to infection and at higher risk developing severe forms COVID-19 compared the general population. Many recommended prevention measures, social distancing self-isolation, not feasible for a population living in shelters characterised by physical proximity high density. The objective study was describe SARS-CoV-2 prevalence Brussels (Belgium), identify factors control practices associated with positivity...
Background.Several studies suggest that the introduction of tacrolimus (TRL), mycophenolic acid (MPA) and interleukin 2 receptor antibodies (IL2Ra) as single drugs more than a decade ago has not increased risk malignancy after renal transplantation. However, only limited data are available on their carcinogenic effects when used in combination potent immunosuppressive regimen.