A5041154053- Renal Transplantation Outcomes and Treatments
- Renal Diseases and Glomerulopathies
- Renal and Vascular Pathologies
- Pharmacological Effects and Toxicity Studies
- Organ Donation and Transplantation
- Dialysis and Renal Disease Management
- Cytomegalovirus and herpesvirus research
- Pregnancy and Medication Impact
- Neurological Complications and Syndromes
- Metabolism and Genetic Disorders
- COVID-19 Clinical Research Studies
- Viral-associated cancers and disorders
- Transplantation: Methods and Outcomes
- Organ Transplantation Techniques and Outcomes
- SARS-CoV-2 and COVID-19 Research
- Polyomavirus and related diseases
- Antifungal resistance and susceptibility
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Extracellular vesicles in disease
- Long-Term Effects of COVID-19
- Vasculitis and related conditions
- Lymphoma Diagnosis and Treatment
- Fungal Infections and Studies
- Neurological and metabolic disorders
- Abdominal vascular conditions and treatments
Hospital Universitari Germans Trias i Pujol
2013-2022
Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol
1997-2022
Instituto de Salud Carlos III
2016-2020
Universitat Autònoma de Barcelona
1995-2016
Fundación Renal
2016
Hospital Universitario Fundación Jiménez Díaz
2015
Pediatric Nephrology of Alabama
2007
Hospital Municipal de Badalona
1989-1991
Abstract Plasmodium vivax is the most widely distributed human malaria parasite. Previous studies have shown that circulating microparticles during P. acute attacks are indirectly associated with severity. Extracellular vesicles (EVs) therefore major components of plasma holding insights into pathological processes. Here, we demonstrate plasma-derived EVs from patients ( Pv EVs) preferentially uptaken by spleen fibroblasts h SFs) as compared to uptake healthy individuals. Moreover, this...
Prolonged-release tacrolimus was developed to provide a more convenient once-daily dosing that could improve patient adherence. We conducted multicenter, prospective, observational, 12-month study describe the efficacy, safety and preference of conversion from twice-daily formulation in stable kidney transplant recipients routine clinical practice. Conversion made on 1 mg: mg basis (1 1.1 patients with trough levels <6 ng/mL). The included 1832 (mean age (± SD): 50.0 ± 13.4 years; 62.7%...
The prognostic factors and optimal therapy for invasive pulmonary aspergillosis (IPA) after kidney transplantation (KT) remain poorly studied. We included in this multinational retrospective study 112 recipients diagnosed with probable (75.0% of cases) or proven (25.0%) IPA between 2000 2013. median interval from to diagnosis was 230 days. Cough, fever, expectoration were the most common symptoms at presentation. Bilateral involvement observed 63.6% cases. Positivity rates galactomannan...
The SARS-CoV-2 (Covid-19) coronavirus pandemic is evolving very quickly and means a special risk for both immunosuppressed comorbid patients. Knowledge about this growing infection also increasing although many uncertainties remain, especially in the kidney transplant population. This manuscript presents proposal action with general specific recommendations to protect prevent vulnerable population such as recipients.
The SARS-CoV-2 (Covid-19) coronavirus pandemic is evolving very quickly and means a special risk for both immunosuppressed comorbid patients. Knowledge about this growing infection also increasing although many uncertainties remain, especially in the kidney transplant population. This manuscript presents proposal action with general specific recommendations to protect prevent vulnerable population such as recipients. La pandemia por está evolucionando de manera muy rápida y representa un...
BackgroundKidney recipients maintaining a prolonged allograft survival in the absence of immunosuppressive drugs and without evidence rejection are supposed to be exceptional. The ERA-EDTA-DESCARTES working group together with Nantes University launched European-wide survey identify new patients, describe them estimate their frequency for first time.
Background Skin cancer is the most common malignancy occurring in kidney transplant recipients (KTRs). Objectives Our purpose was to investigate, prospectively, cumulative incidence of cancerous and precancerous skin lesions as well their risk factors a close follow‐up population KTRs from Mediterranean area Spain. Patients methods One hundred seventy‐four consecutive were examined at moment then 6‐month intervals. The computed. To analyse role potential (age transplantation, cause renal...
Background. Tacrolimus-based immunosuppression, the most widely used regimen in kidney transplantation, increases risk of new onset diabetes after transplantation (NODAT). However, prevalence, evolution and factors different prediabetic alterations: impaired fasting glucose, glucose tolerance, provisional diabetes, have not been established. Methods. In this multicenter prospective study we evaluated 154 nondiabetic transplant recipients receiving tacrolimus, mycophenolate mofetil low dose...
Risk factors for invasive pulmonary aspergillosis (IPA) after kidney transplantation have been poorly explored. We performed a multinational case-control study that included 51 transplant (KT) recipients diagnosed with early (first 180 posttransplant days) IPA at 19 institutions between 2000 and 2013. Control were matched (1:1 ratio) by center date of transplantation. Overall mortality among cases was 60.8%, 25.0% living experienced graft loss. Pretransplant diagnosis chronic obstructive...
Abstract Background In kidney transplantation, fibrosis represents the final and irreversible consequence of pathogenic mechanisms that lead to graft failure, in late stages it irremediably precedes loss renal function. The invasiveness biopsy prevents this condition from being frequently monitored, while clinical data are rather unspecific. objective study was find noninvasive biomarkers rejection. Methods We carried out proteomic analysis urinary Extracellular Vesicles (uEVs) a cohort...
New-onset diabetes mellitus after transplantation (NODAT) is a severe complication of kidney (KTx) with negative effects upon patient and graft survival. Several risk factors for NODAT have been described; however, the search an early predictive marker ongoing. It has recently demonstrated that high concentrations adiponectin (APN), which adipocyte-derived peptide antiinflammatory insulin-sensitizing properties, protect against future development type 2 in healthy individuals. The purpose...
Background. Statins prevent the progression of transplant vasculopathy in heart transplants, but its beneficial effect on transplanted kidney is controversial. Methods. The aim to evaluate utility fluvastatin 80 mg/day reduce 6-month renal a multicenter, prospective, randomized, placebo-controlled trial stratified according donor age. All patients received cyclosporine, mycophenolate mofetil, and prednisone. was evaluated paired protocol biopsies. primary efficacy variable mean arterial...
Kidney transplantation (KTx) is the best therapeutic approach for chronic kidney diseases leading to irreversible failure. Considering origin of graft, several studies have reported differences between living (LD) and deceased donors (DD) in graft patient survival. These seem be related multiple factors including, donor age time cold ischemia among others. Many transplanted organs come from old-aged DDs, which pre-transplant biopsy recommended. However, has limitations, there a need develop...
Background. Cardiovascular disease and chronic allograft nephropathy (CAN) are two of the main complications observed in patients after renal transplantation. Both appear to be manifestations same process, which inflammation plays a determinate role. Pregnancy-associated plasma protein A (PAPP-A) has been shown marker acute coronary syndrome cardiovascular pathology. The objective this study was demonstrate whether or not serum concentration pretransplant PAPP-A is CAN predictor...
There is some evidence pointing toward better renal function in kidney transplant recipients (KTR) treated with once-daily tacrolimus (QD-TAC) vs. twice-daily (BID-TAC).This an extension study of a 1-year, single arm prospective stable KTR who were converted from BID-TAC to QD-TAC (4.9 ± 4.0 years after transplantation) Spanish routine clinical practice. Patient and graft survival, function, acute rejection episodes, other analytic parameters assessed at 24 36 months conversion.A total 1798...
Chronic immunosuppression promotes nonmelanocytic squamous cell carcinoma (SCC) after kidney transplantation. Adaptive and innate immunity play a key role controlling tumor growth are influenced by different immunosuppressive agents. We hypothesized that functional impairment of tumor-specific T responses due to calcineurin inhibitors (CNI) could contribute SCC development, whereas conversion mammalian target rapamycin (mTOR-i) recover this protective immune response.Peripheral against main...
Use of immunosuppressive drugs is still unavoidable in kidney-transplanted patients. Since their discovery, calcineurin inhibitors (CNI) have been considered the first-line agents, spite known nephrotoxicity. Chronic CNI toxicity (CNIT) may lead to kidney fibrosis, a threatening scenario for graft survival. However, there controversy regarding CNIT diagnosis, monitoring and therapeutic management, specific effects at molecular level are not fully known. Aiming better characterize patients,...