A5080826324- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Cytomegalovirus and herpesvirus research
- Pharmacological Effects and Toxicity Studies
- Liver Disease and Transplantation
- Neurological Complications and Syndromes
- Organ Donation and Transplantation
- Hepatitis C virus research
- Renal and Vascular Pathologies
- Renal Diseases and Glomerulopathies
- Biomedical Research and Pathophysiology
- Pregnancy and Medication Impact
- Complement system in diseases
- Neonatal Health and Biochemistry
- Parvovirus B19 Infection Studies
- COVID-19 Clinical Research Studies
- Fungal Infections and Studies
- Hepatitis B Virus Studies
- Hepatitis Viruses Studies and Epidemiology
- Parathyroid Disorders and Treatments
- Antifungal resistance and susceptibility
- Liver Diseases and Immunity
- Bone and Joint Diseases
- Methemoglobinemia and Tumor Lysis Syndrome
- Dialysis and Renal Disease Management
Santa Lucía University General Hospital
2025
Vall d'Hebron Hospital Universitari
2010-2024
Sistema Nacional de Salud
2022-2023
Universitat Autònoma de Barcelona
2013-2022
Pediatric Nephrology of Alabama
2020
Weatherford College
2020
Vall d'Hebron Institut de Recerca
2016-2017
Puigvert Foundation
2016
There are no approved treatments for chronic antibody mediated rejection (ABMR). We conducted a multicenter, prospective, randomized, placebo-controlled, double-blind clinical trial to evaluate efficacy and safety of intravenous immunoglobulins (IVIG) combined with rituximab (RTX) (EudraCT 2010-023746-67). Patients transplant glomerulopathy anti-HLA donor-specific antibodies (DSA) were eligible. estimated glomerular filtration rate (eGFR) <20 mL/min per 1.73m2 and/or severe interstitial...
Kidney transplant recipients might be at higher risk for severe coronavirus disease 2019 (COVID-19). However, factors relevant outcomes remain uncertain in this population. This is a multicentric kidney cohort including 104 hospitalized patients between March 4 and April 17, 2020. Risk death acute respiratory distress syndrome (ARDS) were investigated, clinical laboratory data analyzed. The mean age was 60 years. Forty-seven (54.8%) developed ARDS. Obesity associated to ARDS development (OR...
Antiviral prophylaxis is recommended in cytomegalovirus (CMV)-seropositive kidney transplant (KT) recipients receiving antithymocyte globulin (ATG) as induction. An alternative strategy of premature discontinuation after CMV-specific cell-mediated immunity (CMV-CMI) recovery (immunoguided prevention) has not been studied. Our aim was to determine whether it effective and safe discontinue when CMV-CMI detected continue with preemptive therapy.In this open-label, noninferiority clinical trial,...
Background. Recently, different therapeutic lines have been tried in the initial stage of disease COVID-19, including remdesivir and molnupiravir. There is scarce evidence on efficacy safety molnupiravir kidney transplant recipients (KTRs). Methods. ingle-center prospective cohort study‚ all adult KTRs diagnosed with COVID-19 treated or from January to April 2022 were included. Results. Nine SARS-CoV-2 (Omicron variant) infection mild symptoms received an outpatient basis compared a similar...
Risk factors for invasive pulmonary aspergillosis (IPA) after kidney transplantation have been poorly explored. We performed a multinational case-control study that included 51 transplant (KT) recipients diagnosed with early (first 180 posttransplant days) IPA at 19 institutions between 2000 and 2013. Control were matched (1:1 ratio) by center date of transplantation. Overall mortality among cases was 60.8%, 25.0% living experienced graft loss. Pretransplant diagnosis chronic obstructive...
Abstract Background Whether antibiotic treatment of asymptomatic bacteriuria (AB) can prevent acute graft pyelonephritis (AGP) in kidney transplant (KT) recipients has not been elucidated. Methods In this multicenter, open-label, nonblinded, prospective, noninferiority, randomized controlled trial, we compared with no for AB KT the first year after transplantation when urinary catheters had removed. The primary endpoint was occurrence AGP. Secondary endpoints included bacteremic AGP,...
Abstract The survival after renal transplantation of patients with antineutrophil cytoplasmic antibody ( ANCA )‐associated to systemic vasculitis is as good in other diseases, although most the reports are based on small numbers patients. Furthermore, it not known whether comorbidities (cardiovascular [ CV ] disease and cancer) more frequent than general population. We report our experience analysis published data this topic. outcome 49 ‐associated vessel was compared a control group....
Cystinosis is a rare systemic lysosomal storage disease that mainly affects the kidney and eye. Renal replacement therapy started in patients with cystinosis during first decade of life absence treatment. The prognosis depends on early diagnosis prompt start good compliance cysteamine Kidney progression, extra-renal complications shorter expectancy are more pronounced who do not adhere to aim this work was establish recommendations for comprehensive care facilitate patient transition from...
La cistinosis es una enfermedad lisosomal minoritaria de expresión sistémica con especial afectación renal y oftalmológica, en la que los pacientes inician terapia sustitutiva primera década vida ausencia tratamiento. El pronóstico depende del diagnóstico precoz, pronta instauración tratamiento cisteamina el buen cumplimiento terapéutico. progresión las complicaciones extrarrenales menor supervivencia, son más acentuadas no adherentes. objetivo este trabajo fue elaboración unas...
ABSTRACT Background Small cohort studies have reported high parathyroid hormone (PTH) levels in patients with Bartter syndrome and lower serum phosphate anecdotally been Gitelman syndrome. In this cross-sectional study, we assessed PTH homeostasis a large of salt-losing tubulopathies. Methods Clinical laboratory data 589 were provided by members the European Rare Kidney Diseases Reference Network (ERKNet) Society for Paediatric Nephrology (ESPN). Results A total 285 304 included analysis....
Abstract Introduction Transplant glomerulopathy ( TG ) is the characteristic lesion of chronic antibody‐mediated rejection AMR ). However, in some patients presents with no circulating HLA antibodies or C4d positivity. Aim Patients accomplishing criteria for were compared to isolated . and Methods We reviewed late (>6 months) graft biopsies performed between 2007 2010 (n = 75). Biopsies C4d‐negative donor‐specific antibody called 12), was defined according Banff consensus 17). evaluated...
Tacrolimus is the cornerstone of immunosuppressive therapy after kidney transplantation. Its narrow therapeutic window mandates serum level strict monitoring and dose adjustments to ensure optimal risk-benefit balance. This observational retrospective study analyzed effectiveness safety conversion from twice-daily immediate-release tacrolimus (IR-Tac) or once-daily prolonged-release (PR-Tac) recent formulation MeltDose® extended-release (LCP-Tac) in 365 stable transplant recipients. We...
Improved outcome and longer life-expectancy in patients with cystinosis, disease complexity itself, justify planning a guided-transition of affected from Pediatrics to adult medicine. The aims the process are guarantee continuum care patient empowerment, moving guardian-care self-care.review articles, expert opinion anonymous surveys patients, relatives advocacy groups.elaboration new document support coordinate transition cystinosis providing specific proposals variety medical fields,...
Introduction. Renal allograft half-life time (t½) is the most straightforward representation of long-term graft survival. Since some statistical models overestimate this parameter, we compare different approaches to evaluate t½. Patients and methods. with a 1-year functioning transplanted in Spain during 1990, 1994, 1998 2002 were included. Exponential, Weibull, gamma, lognormal log-logistic censoring last year follow-up evaluated. The goodness fit these was evaluated according Cox–Snell...
Improved outcome and longer life expectancy in patients with cystinosis the intrinsic complexity of disease, underline need for a guided transition from pediatric to adult care. The process aims guarantee continuum care enable empowerment guardian self-care. Bibliography review, expert opinion anonymous surveys patients, relatives patient advocacy groups. A new plan support coordinate cystinotic providing specific proposals variety medical fields improved treatment adherence. Nephrologists...
Multicenter, prospective, observational study to compare the relative bioavailability of once-daily tacrolimus formulations in de novo kidney transplant recipients. De recipients who started a tacrolimus-based regimen were included 14 days post-transplant and followed up for 6 months. Data from 218 participants evaluated: 129 LCPT group (Envarsus) 89 PR-Tac (Advagraf) group. Patients exhibited higher (Cmin /total daily dose [TDD]) vs. (61% increase; P < .001) with similar Cmin 30% lower TDD...