A5079614063- Renal Transplantation Outcomes and Treatments
- Parathyroid Disorders and Treatments
- Dialysis and Renal Disease Management
- Chronic Kidney Disease and Diabetes
- Renal and Vascular Pathologies
- Organ Transplantation Techniques and Outcomes
- Diabetes Treatment and Management
- Organ Donation and Transplantation
- Renal Diseases and Glomerulopathies
- Pharmacological Effects and Toxicity Studies
- Pancreatic function and diabetes
- Neurological Complications and Syndromes
- Metabolism and Genetic Disorders
- Magnesium in Health and Disease
- Kidney Stones and Urolithiasis Treatments
- Bone health and treatments
- Bone and Joint Diseases
- Genetic Syndromes and Imprinting
- Bone health and osteoporosis research
- Vitamin D Research Studies
- Metabolism, Diabetes, and Cancer
- Hematopoietic Stem Cell Transplantation
- Porphyrin Metabolism and Disorders
- Diabetes and associated disorders
- Liver Disease and Transplantation
The Royal Melbourne Hospital
2025
Universidad de La Laguna
2015-2024
Universidade de São Paulo
2024
Hospital Universitario de Canarias
2015-2024
Universidad de Ingeniería y Tecnología
2024
Higher Institute of Technologies and Applied Sciences
2023
Hospital Universitario Reina Sofía
1996-2023
RELX Group (United States)
2019-2021
Landscape Research Group
2021
RELX Group (Netherlands)
2021
The European Best Practice Guideline group (EBPG) issued guidelines on the evaluation and selection of kidney donor transplant candidates, as well post-transplant recipient care, in year 2000 2002. new Renal board decided 2009 that these needed updating. In order to avoid duplication efforts with disease improving global outcomes, which published clinical practice care recipients, we did not address issues present guidelines. guideline was developed following a rigorous methodological...
Phosphorus retention is an important factor in the development of hyperparathyroidism secondary to renal failure. In vivo manipulation phosphorus associated with changes serum calcium and calcitriol levels which turn can modify parathyroid hormone synthesis secretion. The present vitro study evaluates whether high extracellular has a direct effect on Fresh rat glands were incubated media concentrations 1, 2, 3, 4 mM subsequently exposed ranging from 0.4 1.35 mM. 1.25 calcium, secretion rate...
Phosphate retention plays an important role in the pathogenesis of secondary hyperparathyroidism patients with renal failure. In vitro studies, high extracellular phosphate levels directly stimulate PTH secretion rat and bovine parathyroid tissue. The present study evaluates effect on production prepro mRNA human hyperplastic glands. includes glands obtained from primary adenomas hemodialysis kidney-transplant diffuse nodular hyperplasia. experiments were performed using small pieces ability...
There are no approved treatments for chronic antibody mediated rejection (ABMR). We conducted a multicenter, prospective, randomized, placebo-controlled, double-blind clinical trial to evaluate efficacy and safety of intravenous immunoglobulins (IVIG) combined with rituximab (RTX) (EudraCT 2010-023746-67). Patients transplant glomerulopathy anti-HLA donor-specific antibodies (DSA) were eligible. estimated glomerular filtration rate (eGFR) <20 mL/min per 1.73m2 and/or severe interstitial...
The long-term clinical evolution of prediabetes and post-transplant diabetes mellitus (PTDM) is unknown. We analysed, in this cohort study, the reversibility, stability progression PTDM 672 patients using repeated oral glucose tolerance tests (OGTTs) for ≤5 years. Most were on tacrolimus, steroids mycophenolate. About half developed either or prediabetes. incidence was 32% bimodal: early (≤3 months) late PTDM. Early reverted 31%; with use OGTTs necessary to detect around Pretransplant...
Stenosis of the subclavian vein (SVS) after cannulation occurs in 15 to 50% chronic hemodialysis patients, and impedes placement an arteriovenous fistula ipsilateral arm. Its natural history pathogenic mechanisms are not well established. This study examined 42 consecutive renal failure patients (28 men 14 women; 46+/-19 yr) whom catheters had been placed as initial vascular access for hemodialysis. All underwent sequential venography studies: at baseline (24 48 h removal catheter) 1, 3, 6...
Mutations in the alanine-glyoxylate amino transferase gene (AGXT) are responsible for primary hyperoxaluria type I, a rare disease characterized by excessive hepatic oxalate production that leads to renal failure. We generated null mutant mouse targeted mutagenesis of homologous gene, Agxt, embryonic stem cells. Mutant mice developed normally, and they exhibited crystalluria. Approximately half male mixed genetic background calcium urinary stones. Severe nephrocalcinosis failure after...
The purpose of this Clinical Practice Guideline is to provide guidance on evaluation the kidney donor and transplant recipient as well management in perioperative period.It designed information aid decision-making.It not intended define a standard care, should neither be construed one nor it interpreted prescribing an exclusive course management. Scope target populationThis guideline describes issues related selection recipient.It encompasses aspects immunological risk assessment care does...
β Cell transcription factors such as forkhead box protein O1 (FoxO1), v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (MafA), pancreatic and duodenal homeobox 1, neuronal differentiation are dysfunctional in type 2 diabetes mellitus (T2DM). Posttransplant resembles T2DM reflects interaction between pretransplant insulin resistance immunosuppressants, mainly calcineurin inhibitors (CNIs). We evaluated the effect of tacrolimus (TAC), cyclosporine (CsA), metabolic stressors (glucose...
Primary hyperoxaluria type 1 (PH1) is an inborn error of metabolism resulting from a deficiency alanine:glyoxylate aminotransferase (AGXT; EC 2.6.1.44). Most the PH1 alleles detected in Canary Islands carry Ile-244 → Thr (I244T) mutation AGXT gene, with 14 16 patients homozygous for this mutation. Four polymorphisms within and regional microsatellites also were shared their haplotypes ( * LTM ), consistent founder effect. The consequences these amino acid changes investigated. Although I244T...
Lack of resolution hyperparathyroidism after long-term renal transplantation is common. The relative roles the graft function attained and degree pre-transplant have not been established. Intact parathyroid hormone (iPTH) several clinical parameters were studied before 68.6+/-26.8 months (range: 30-124) in 62 patients (20 females/42 males) with good (creatinine <2 mg/dl). iPTH decreased from 214+/-229 pre-transplantation to 116+/-70 pg/ml post-transplantation (P<0.01). However, only 22.6%...
Aplastic bone disease (ABD) is a common form of renal osteodystrophy and characterized by defect in matrix formation mineralization without an increase osteoid thickness. The prevalence pathogenesis ABD predialysis patients largely unknown. We prospectively studied 92 unselected with creatinine clearance <10 ml/min/1.73 m2 mean age 45±2 years (61 M, 31 F). None the study had received any vitamin D therapy, CaCO3 was primary phosphate binder. observed 30 (32%) patients. Stainable aluminium...
Journal Article Acute Chagas' Disease in a Recipient of Bone Marrow Transplant Spain: Case Report Get access Rafael Villalba, Villalba From the Departments Hematology and Neurology, University Hospital "Reina Sofia,"Cordoba, Spain Search for other works by this author on: Oxford Academic PubMed Google Scholar Gema Fornés, Fornés Miguel A. Alvarez, Alvarez José Román, Román Vicente Rubio, Rubio Margarita Fernández, Fernández J. Manuel García, García Monserrat Viñals, Viñals Antonio Torres...
Risk factors for surgical complications (SCs) following kidney transplantation in the modern transplant era need to be identified perform appropriate prophylactic interventions.Records from 870 consecutive adult cadaveric transplants done at a single centre were reviewed. SCs classified into four groups: (i) vascular (12%, thrombosis or stenosis); (ii) haemorrhagic (12%); (iii) ureteral (7.5%, leaks and stenosis) (iv) wound (16%, lymphocoeles dehiscences).One more occurred 299 (34%)...