A5086194342- Kidney Stones and Urolithiasis Treatments
- Pediatric Urology and Nephrology Studies
- Ureteral procedures and complications
- Urological Disorders and Treatments
- Bladder and Urothelial Cancer Treatments
- Pancreatitis Pathology and Treatment
- Renal and Vascular Pathologies
- Renal cell carcinoma treatment
- Bone and Dental Protein Studies
- Urinary and Genital Oncology Studies
- Cancer Immunotherapy and Biomarkers
- Chronic Kidney Disease and Diabetes
- Porphyrin Metabolism and Disorders
- Urologic and reproductive health conditions
- Urinary Bladder and Prostate Research
- Parathyroid Disorders and Treatments
- Prostate Cancer Diagnosis and Treatment
- Pelvic floor disorders treatments
- Metabolism and Genetic Disorders
- Therapeutic Uses of Natural Elements
- Paleopathology and ancient diseases
- Dermatological and Skeletal Disorders
- Dialysis and Renal Disease Management
- Surgical Simulation and Training
- Renal and related cancers
Nagoya City University
2016-2025
Mizuho (Japan)
2016-2025
Himeji Red Cross Hospital
2023
City University of Seattle
2022
SMART Reading
2021
Park University
2020
Seattle University
2020
Toyota Kosei Hospital
2013-2018
Loyola University Chicago
2018
Canadian Institute for Health Information
2017
Background and Purpose: Percutaneous nephrolithotomy (PCNL) is considered the standard procedure for removal of large renal calculi. The development "minimally invasive PCNL" (mini-PCNL) has reduced complications surgery; it also appears to be associated with less morbidity than conventional PCNL (con-PCNL). This study aimed at evaluating efficacy endoscopic intrarenal surgery, using prone-split leg position, flexible ureteroscopy mini-PCNL (mini- combined surgery [ECIRS]) by retrospectively...
Randall plaques (RPs) can contribute to the formation of idiopathic calcium oxalate (CaOx) kidney stones; however, genes related RP have not been identified. We previously reported potential therapeutic role osteopontin (OPN) and macrophages in CaOx stone formation, discovered using genome-recombined mice genome-wide analyses. Here, characterize genetic pathogenesis RPs, we used microarrays immunohistology compare gene expression among renal papillary non-RP tissues 23 formers (SFs) (age-...
Abstract In our previous report, M2-macrophage (Mφs) deficient mice showed increased renal calcium oxalate (CaOx) crystal formation; however, the role of Mφs-related-cytokines and chemokines that affect kidney stone formation remains unknown. Here, we investigated M1/M2s in development by using vitro vivo approaches. The phagocytic rate bone marrow-derived M2Mφs was higher than Mφs M1Mφs on co-culture with tubular cells (RTCs). However, amount attachment RTCs reduced M2Mφs. six hyperoxaluric...
Mice have a strong ability to eliminate renal calcium oxalate crystals, and our previous examination indicated susceptibility in which monocyte-macrophage interaction could participate the phenomenon. To clarify macrophage-related factors playing roles prevention of crystal formation mouse kidneys, morphologic expression studies based on microarray pathway analysis were performed. Eight-week-old male C57BL/6N mice administered 80 mg/kg glyoxylate by daily intraabdominal injection for 15...
We recently reported evidence suggesting that migrating macrophages (Mϕs) eliminate renal crystals in hyperoxaluric mice. Mϕs can be inflammatory (M1) or anti-inflammatory (M2), and colony-stimulating factor-1 (CSF-1) mediates polarization to the M2Mϕ phenotype. M2Mϕs promote tissue repair regeneration, but it is not clear whether these cells are involved suppressing crystal formation. investigated role of formation during hyperoxaluria using CSF-1–deficient mice, which lack M2Mϕs. Compared...
We sought to identify and quantitatively analyze calcium oxalate (CaOx) kidney stones on the order of micrometers, with a focus quantitative identification monohydrate (COM) dihydrate (COD). performed Fourier transform infrared (FTIR) spectroscopy, powder X-ray diffraction (PXRD), microfocus computed tomography measurements (microfocus CT) compared their results. An extended analysis FTIR spectrum focusing 780 cm −1 peak made it possible achieve reliable COM/COD ratio. succeeded in 50-μm 2...
Abstract We previously established a mouse kidney stone formation model and showed that mice have higher tolerance to than rats. Furthermore, we the generated calcium oxalate crystal deposits could be eliminated after several days. This study investigated transcriptome of elimination in based on gene selection using microarray technique. Eight-week-old male C57BL/6N were administered 80 mg/kg glyoxylate for 15 days, depositions had increased by day 6; thereafter, decreased gradually almost...
To clarify metabolic syndrome induced stone formation mechanisms we investigated the and immunohistochemical characteristics associated with renal crystal deposition using a model of mice administered high fat diet ethylene glycol.Ob/Ob Leptin gene deficiencies related were compared wild heterozygous lean mice. Four study groups fed standard food water (control group), normal (high 1% glycol (ethylene group) or plus group). Blood, urine kidney samples taken after 14 days.Ob/Ob in group...
Kidney stone disease is a lifestyle-related prevalent in developed countries; however, effective medical treatment for the not yet well established. As cellular damage renal tubular cells (RTCs) responsible disease, here, we focused on role of macroautophagy/autophagy RTCs. We found that autophagic activity was significantly decreased mouse RTCs exposed to calcium oxalate (CaOx) monohydrate crystals and kidneys GFP-conjugated MAP1LC3B (microtubule- associated protein 1 light chain 3 beta)...
To clarify the role of renal tubular cell (RTC) injury and oxidative stress in early stage calcium oxalate crystal formation a mouse model.Daily intra-abdominal injections glyoxylate (1.35 mmol/kg/day) into 8-week-old mice were carried out over 6 days. Kidneys extracted before at 6, 12 24 h 3 days after injection. Crystal was detected using Pizzolato staining polarized light optical microscopy. Immunohistochemical western blotting superoxide dismutase, 4-hydroxynonenal malondialdehyde order...
An important process in kidney stone formation is the conversion of retentive crystals renal tubules to concrete stones. Osteopontin (OPN) major component calcium-containing matrix. In this study, we estimated OPN function early morphological changes calcium oxalate using knockout mice: 100 mg/kg glyoxylate was intra-abdominally injected into wildtype mice (WT) and (KO) for a week, 24-h urine excretion showed no significant difference between WT KO. Kidney crystal depositions were clearly...
This study was performed to evaluate the impact of pelvicaliceal anatomy on stone clearance in patients with remnant fragments lower pole after flexible ureteroscopy and holmium laser lithotripsy (fURSL) for renal stones >15 mm.This retrospective included 67 radiopaque residual (>2 mm) fURSL large (>15 mm). The preoperative infundibular length (IL), width (IW), infundibulopelvic angle (IPA), caliceal pelvic height (CPH) were measured using intravenous urography. Multivariate analysis...
Ipilimumab and nivolumab treatment against advanced metastatic renal cell carcinoma (RCC) causes severe lethal immune-related adverse events (irAEs). Predicting irAEs might improve clinical outcomes, however no practical biomarkers exist. This study examined whether eosinophils could be effective for ≥grade 2 in RCC.We retrospectively analyzed 75 patients with RCC treated ipilimumab between August 2018 March 2021 a multicenter study. Eosinophils were before weeks after treatment, immediately...
The aims of the present study were to elucidate a possible mechanism kidney crystal formation by using metabolic syndrome (MetS) mouse model and assess effectiveness adiponectin treatment for prevention crystals. Further, we performed genome-wide expression analyses investigating novel genetic environmental changes. Wild-type (+/+) mice showed no formation, whereas ob/ob depositions in their renal tubules. However, this deposition was remarkably reduced adiponectin. Expression analysis genes...
We developed an in vitro system composed of renal tubular cells, adipocytes and macrophages to simulate metabolic syndrome conditions. investigated the molecular communication mechanism these cells their involvement kidney stone formation.Mouse (M-1) were cocultured with (3T3-L1) and/or (RAW264.7). Calcium oxalate monohydrate crystals exposed M-1 after 48-hour coculture number calcium adherent was quantified. The expression medium cell inflammatory factors analyzed by enzyme-linked...
Background/Objectives: Immuno-oncology plus tyrosine kinase inhibitor (IO+TKI) combination therapy is an essential first-line for advanced renal cell carcinoma (RCC). However, reports of its efficacy and safety as late-line are lacking. This study aimed to examine the IO+TKI a patients with RCC. Methods: We retrospectively examined 17 RCC who received second-line or beyond (pembrolizumab axitinib, n = 10; avelumab 5; nivolumab cabozantinib, 2). Results: The overall response disease control...