A5004865087- Trace Elements in Health
- Pediatric Urology and Nephrology Studies
- Parathyroid Disorders and Treatments
- Kidney Stones and Urolithiasis Treatments
- Heavy Metal Exposure and Toxicity
- Vascular anomalies and interventions
- Vitamin D Research Studies
- Pharmacological Effects and Toxicity Studies
- Magnesium in Health and Disease
- Coronary Artery Anomalies
- Dialysis and Renal Disease Management
- Urological Disorders and Treatments
- Systemic Lupus Erythematosus Research
- Renal and Vascular Pathologies
- Muscle and Compartmental Disorders
- Renal Diseases and Glomerulopathies
- Genetic and Kidney Cyst Diseases
- Nephrotoxicity and Medicinal Plants
- Corporate Taxation and Avoidance
- Therapeutic Uses of Natural Elements
- Intraoperative Neuromonitoring and Anesthetic Effects
- Phase-change materials and chalcogenides
- Biomedical Research and Pathophysiology
- Urinary Tract Infections Management
- Renal function and acid-base balance
McMaster Children's Hospital
2016-2025
Tokuda Hospital
2025
Acıbadem Adana Hospital
2025
McMaster University
2012-2024
London Health Sciences Centre
2023
Hamilton Health Sciences
2013-2022
Leeds Teaching Hospitals NHS Trust
2014
University of Manchester
2010
Royal Manchester Children's Hospital
2007-2008
Great Ormond Street Hospital
1998-2002
Steroid-sensitive nephrotic syndrome (SSNS) accounts for >80% of cases in childhood. However, the etiology and pathogenesis SSNS remain obscure. Hypothesizing that coding variation may underlie risk, we conducted an exome array association study SSNS. We enrolled a discovery set 363 persons (214 South Asian children with 149 controls) genotyped them using Illumina HumanExome Beadchip. Four common single nucleotide polymorphisms (SNPs) HLA-DQA1 HLA-DQB1 (rs1129740, rs9273349, rs1071630,...
Abstract Background Primary hyperoxaluria type 1 (PH1) is an autosomal recessive disorder with dysregulated glyoxylate metabolism in the liver. Oxalate over-production leads to renal stones, progressive kidney damage and failure, potentially life-threatening systemic oxalosis. Nedosiran a synthetic RNA interference therapy, designed reduce hepatic lactate dehydrogenase (LDH) decrease oxalate burden PH. Methods Currently, PHYOX8 study (NCT05001269), pediatric participants (2–11 years) PH1 ( N...
Abstract Acute type A aortic dissection, despite treatment advances, remains a critical emergency with markedly high morbidity and mortality rates. The primary goals of immediate surgical intervention are to ensure survival, prevent severe complications, avoid subsequent interventions. We present case 55-year-old male who presented new-onset chest pain, dyspnea, hypotension. Emergent transthoracic echocardiography computed tomography revealed an ascending dissection. patient underwent repair...
The purpose of this study was to assess the vitamin D status children with renal disease attending outpatient clinics our tertiary nephrology centre, allowing us determine prevalence deficiency and its relationship glomerular filtration rate (GFR) serum parathyroid hormone (PTH) concentration.90 boys 53 girls (99 white Caucasians, 38 South Asian origin six from other ethnic groups) were enrolled into study. 18 on dialysis (15 peritoneal three haemodialysis), 61 had a functioning transplant...
New methods for quantitative analysis of strong anions are required diagnostic testing human diseases. Current techniques suffer from poor selectivity and/or long times that not amenable labile in high-saline or volume-restricted samples. We introduce a rapid assay (<5 min) based on capillary electrophoresis (CE) with indirect UV detection simultaneous sulfate, sulfite, and chloride urine, plasma, sweat specimens. Remarkable is achieved by using an acidic background electrolyte under...
Objectives Although many secondary effects of high levels vanadium (V) and chromium (Cr) overlap with symptoms seen in paediatric patients chronic kidney disease (CKD), their plasma V Cr are understudied. Design Ancillary cross-sectional study to a prospective, longitudinal, randomised controlled trial. Setting Children’s Hospital Western Ontario, London Health Sciences Centre, London, Canada. Participants 36 children adolescents 4–18 years age CKD. Interventions 1–6 trace element...
High levels of fibroblast growth factor-23 (FGF23) are associated with mortality. In chronic kidney disease (CKD), FGF23 rise as renal function declines. We analyzed the contribution laboratory values to variance in relationship a curve expected for given GFR. Following approval by research ethics boards, we measured FGF23, CysC eGFR, creatinine, urea, albumin, calcium, phosphate, vitamin D metabolites, PTH, alkaline phosphatase, CRP, and venous gases 141 pediatric CKD patients (45, 37, 32,...
Abstract Background Manganese (Mn) and Selenium (Se) deficiencies are noted in adult patients with chronic kidney disease (CKD). However, levels of these trace elements have not been well studied the paediatric CKD population. We determined Mn Se a single-institution cohort CKD. Methods Ancillary cross-sectional study to prospective longitudinal randomized control trial on zinc supplementation, which included 42 children adolescents aged 0 19 years stages I IV dialysis, who had 1–6 element...
Background: Zinc status, its role in bone metabolism and efficacy of deficiency correction has not been well studied children with chronic kidney disease (CKD). Objectives: The primary objective was to investigate whether 3 months oral zinc supplementation corrects CKD who have native or transplanted kidneys. secondary compare circulating intact FGF-23 (iFGF-23), c-terminal (cFGF-23), Klotho between zinc-sufficient zinc-deficient assess the relationship zinc, iFGF-23, cFGF-23, Klotho,...
Many of the secondary effects high levels molybdenum (Mo) overlap with symptoms commonly seen in pediatric patients chronic kidney disease (CKD). We measured plasma Mo and examined relationship between function.The study was carried out at London Health Sciences Centre London, Ontario, Canada 36 children adolescents 4 - 18 years age CKD. There were 1 6 trace element measurements (Mo copper (Cu)) per patient. studied proportion abnormal estimated glomerular filtration rate (eGFR), calculated...
Dual left anterior descending (LAD) coronary artery with distribution of the vessels from main and right aortic sinus Valsalva is a rare anomaly. Here, we report such anomaly in young female wall myocardial infarction stenting ‘short’ LAD artery, which was subsequently confirmed operating room by multi-slice cardiac computerized tomography after surgery.
Urinary tract infections (UTIs) are common in young children and seen emergency departments (EDs) frequently. Left untreated, UTIs can lead to more severe conditions. Our goal was undertake a quality improvement (QI) initiative help minimize the number of with missed newly established tertiary care pediatric department (PED). A retrospective chart review undertaken identify < 3 years old who presented children’s hospital’s ED positive urine cultures. It found that there no treatment or...
Abstract Transmembrane tyrosine kinase receptors represent a fundamental mechanism for transducing extracellular signals into the activation of signaling cascades responsible intercellular communication, embryogenesis and tissue integrity. The epidermal growth factor receptor (EGFR) is canonical member this family, regarded its dysregulated function in various malignancies. Here, we describe young female born prematurely with friable immature skin who developed chronic diarrhea, recurrent...
Anterior ischemic optic neuropathy (AION) occurs due to hypoperfusion of the nerve and is a rare complication in patients receiving maintenance dialysis. To date, AION has only been reported 22 children, all whom were peritoneal We report first case 2-year 11-month-old child chronic hemodialysis secondary polycystic kidney disease from phosphomannomutase 2 gene mutation. This highlights consideration for frequent blood pressure monitoring ophthalmic screening certain cohort children
Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary renal disorder. The characterized by progressive cyst formation in both kidneys and loss of function, which typically leads to end-stage (ESRD) fourth sixth decade life.1 In majority patients caused a mutation either PKD1-gene or PKD2-gene.S1,S2
Due to nonuniform aggregation in liquid state, from the thermodynamic point of view any glass-forming vicinity liquid-to-solid phase transition temperature, irrespective its actual chemical composition, shall be described terms a complex multicomponent solution whose comprised same elements components have characteristic atomic arrangement deviating various extent ground state with respect size, shape, density, structure, and stoichiometry. Therefore, glass appears process non-equilibrium...