A5069748177- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Dialysis and Renal Disease Management
- Kidney Stones and Urolithiasis Treatments
- Pediatric Urology and Nephrology Studies
- Parathyroid Disorders and Treatments
- Renal function and acid-base balance
- Autoimmune Bullous Skin Diseases
- Renal and related cancers
- Bone health and treatments
- Acute Kidney Injury Research
- Birth, Development, and Health
- Vitamin D Research Studies
- Genetic and Kidney Cyst Diseases
- Ion Transport and Channel Regulation
- Systemic Lupus Erythematosus Research
- Urological Disorders and Treatments
- Genetic Syndromes and Imprinting
- Lymphatic System and Diseases
- Electrolyte and hormonal disorders
- Metabolism and Genetic Disorders
- Bone fractures and treatments
- Fibroblast Growth Factor Research
- Neonatal Respiratory Health Research
Children's Mercy Hospital
2015-2024
University of Missouri–Kansas City
2011-2024
Biomedical Research Foundation
2020-2024
Mercy Health
2024
Kansas City VA Medical Center
2014-2022
Mercy Hospital
2005-2021
University of Missouri
2000-2020
Kobe University
2020
Kitasato University
2020
Tohoku Medical Megabank Organization
2020
Steroid-sensitive nephrotic syndrome (SSNS) accounts for >80% of cases in childhood. However, the etiology and pathogenesis SSNS remain obscure. Hypothesizing that coding variation may underlie risk, we conducted an exome array association study SSNS. We enrolled a discovery set 363 persons (214 South Asian children with 149 controls) genotyped them using Illumina HumanExome Beadchip. Four common single nucleotide polymorphisms (SNPs) HLA-DQA1 HLA-DQB1 (rs1129740, rs9273349, rs1071630,...
CLCF-1 is a cytokine known for B-cell stimulation and neurotrophic properties. We have identified as potential injurious factor in the human renal disease focal segmental glomerulosclerosis (FSGS). investigated its effects on cells function vitro vivo studies. Methods include measurement of effect phosphorylation target molecules JAK/STAT pathway, cytoskeleton cell morphology cultured podocytes, albumin permeability isolated rat glomeruli, tissue urine after acute or chronic injection. In...
According to the WHO, signs of hepatic dysfunction are unusual, and encephalopathy is never seen in malaria. However, recent years, isolated cases have been reported from different parts world.To identify evidence for hepatocyte and/or jaundiced patients with falciparum malaria.Prospective observational study.We studied 86 adult both sexes who had malaria jaundice (serum bilirubin > 3 mg%). The main outcome measures were: flapping tremor, deranged psychometric test, level consciousness,...
Due to environmental and social changes (and possibly obesity) as new risk factors for stone formation in adults imaging techniques, we assessed whether etiologies of primary pediatric urolithiasis have changed, if relationships exist between the condition obesity or technique.All patients with documented who underwent serum 24-hour urine analyses 1999 2010 were evaluated. Age at diagnosis, gender, body mass index technique recorded.Of 222 (48% male) all had normal creatinine, electrolytes...
IntroductionNephrotic syndrome (NS) is a characterized by massive proteinuria, edema, hypoalbuminemia, and dyslipidemia. Glucocorticoids (GCs), the primary therapy for >60 years, are ineffective in approximately 50% of adults 20% children. Unfortunately, there no validated biomarkers able to predict steroid-resistant NS (SRNS) or define pathways regulating SRNS.MethodsWe performed proteomic analyses on paired pediatric patient plasma samples obtained both at disease presentation before...
Glomerular hyperfiltration is emerging as the key risk factor for progression of chronic kidney disease (CKD). Podocytes are exposed to fluid flow shear stress (FFSS) caused by ultrafiltrate within Bowman's space. The mechanism hyperfiltration-induced podocyte injury not clear. We postulated that glomerular in solitary increases FFSS over podocytes. Infant Sprague–Dawley rats at 5 days age and C57BL/6J 14-week-old adult mice underwent unilateral nephrectomy. Micropuncture morphological...
Recently, we and others have found that hyperfiltration-associated increase in biomechanical forces, namely, tensile stress fluid flow shear (FFSS), can directly distinctly alter podocyte structure function. The ultrafiltrate over the major processes cell body generates FFSS to podocytes. Our previous work suggests cyclooxygenase-2 (COX-2)-PGE 2 -PGE receptor (EP2) axis plays an important role mechanoperception of To address mechanotransduction perceived stimulus through EP2, cultured...
Prior cross-sectional studies suggest that health-related quality of life (HRQOL) worsens with more severe glomerular disease. This longitudinal analysis was conducted to assess changes in HRQOL changing disease status.Cure Glomerulonephropathy (CureGN) is a cohort patients minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy, IgA vasculitis, or nephropathy. assessed at enrollment and follow-up visits 1 3 times annually for up 5 years the Patient-Reported...