A5043849266- Parathyroid Disorders and Treatments
- Dialysis and Renal Disease Management
- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Pediatric Urology and Nephrology Studies
- Renal Transplantation Outcomes and Treatments
- Systemic Lupus Erythematosus Research
- Renal and related cancers
- Pharmacological Effects and Toxicity Studies
- Birth, Development, and Health
- Hemoglobinopathies and Related Disorders
- Vitamin D Research Studies
- Blood Pressure and Hypertension Studies
- Magnesium in Health and Disease
- Liver Diseases and Immunity
- Pregnancy and Medication Impact
- Acute Kidney Injury Research
- Genetic Syndromes and Imprinting
- Hepatitis Viruses Studies and Epidemiology
- Polyomavirus and related diseases
- Diabetes and associated disorders
- Neonatal Health and Biochemistry
- Complementary and Alternative Medicine Studies
- Hemodynamic Monitoring and Therapy
- Iron Metabolism and Disorders
University of Miami
2014-2025
Miami Transplant Institute
2024-2025
Clinical Pharmacology of Miami
2024
University of Miami Hospital
2009-2024
Jackson Memorial Hospital
2001-2023
Jackson Health System
2013-2019
Memorial Medical Center
2012
Pediatric Nephrology of Alabama
2011
Anhui Provincial Children's Hospital
2010
Ramathibodi Hospital
2006
Rituximab (RTX), an anti-CD20 monoclonal antibody, has been proposed for use in the therapy of systemic lupus erythematosus (SLE). We present initial long-term experience safety and efficacy rituximab treatment SLE children. Eighteen patients (mean age 14 ± 3 years) with severe were treated after demonstrating resistance or toxicity to conventional regimens. There was a predominance female (16/18) ethnic African (13/18) patients. All had nephritis [World Health Organization (WHO) classes...
Childhood-onset lupus nephritis (LN) carries a worse renal prognosis compared with adults. Controlled treatment trials in children are lacking. We and patient survival cohort of pediatric patients followed over 3 decades.
Vitamin D attenuates uremic cardiac hypertrophy, possibly by suppressing the myocardial renin–angiotensin system (RAS) and fibroblast growth factors (FGFs). We compared suppression of hypertrophy expression RAS FGF receptor genes offered vitamin analog paricalcitol (Pc) or angiotensin-converting enzyme inhibitor enalapril (E) in experimental uremia. Rats with 5/6 nephrectomy received Pc E for 8 weeks. Renal function, systolic blood pressure, were evaluated. Myocardial genes, brain...
Abstract Background Primary FSGS manifests with nephrotic syndrome and may recur following KT. Failure to respond conventional therapy after recurrence results in poor outcomes. Evaluation of podocyte B7-1 expression treatment abatacept (a antagonist) has shown promise but remains controversial. Methods From 2012 2020, twelve patients developed post-KT range proteinuria, failed therapy, were treated abatacept. Nine/twelve (< 21 years old) experienced recurrent FSGS; three adults de novo...
Long-term survival of kidney allografts is limited by multiple factors, including nonadherence. High intrapatient variability in tacrolimus levels (≥30%) associated with de novo donor-specific antibody (dnDSA) formation, increased risk rejection and graft loss. We prospectively analyzed the association between nonadherence pediatric transplant recipients. derived a composite adherence score from 0 to 3 points based on (1) Basel Assessment Adherence Immunosuppressive Medical Scale©; (2)...
Recent advances in the early diagnosis of fetal CAKUT with an increase surgical interventions have led to a growing number neonatal survivors born severe renal dysfunction. This, turn, has required development multi-disciplinary treatment paradigms individualized management these infants advanced stage kidney disease from birth. Early multi-modal includes directed towards establishing adequate urine flow, respiratory support assessment pulmonary hypoplasia, and metabolic control avoid need...
BackgroundPediatric patients with chronic kidney disease (CKD) are at increased risk of early cardiovascular and premature death. Abnormalities in microvascular structure function may presage end-organ damage including vascular calcification myocardial ischemia associated disordered mineral metabolism. Early detection rarefaction (reduced density capillaries) identify at-risk prompt timely therapeutic interventions. Our objective was to study capillary pediatric hemodialysis (HD) determine...
In uremic animals, vitamin D receptor (VDR) agonists like paricalcitol (Pc) attenuate cardiac hypertrophy, but this effect has not been replicated consistently in humans with chronic kidney disease. Elevated fibroblast growth factor 23 (FGF23) levels cause hypertrophy activation of the myocardial calcineurin/nuclear activated T cell (NFAT) axis and may antagonize cardioprotective effects VDR agonist therapy. We hypothesized that effectiveness Pc depend on prevailing circulating FGF23 could...
Background Mutations of the Wilms tumor suppressor-1 gene ( WT1) are associated with life-threatening glomerulopathy, disorders sexual development, Wilm's tumor, and gonadal malignancies. Our objectives were to describe clinical presentations, age progression, onset complications WT1 mutation through a case series literature review. Methods A retrospective study included all patients followed at University Miami/Holtz Children's Hospital from January 2000 December 2020 diagnosis . review...
Background The mechanisms responsible for the hyperphosphatemia in patients with sickle cell disease (SCD) and preserved glomerular filtration rate (GFR) are not fully understood. role of fibroblast growth factor 23 (FGF23), a phosphaturic hormone has been investigated SCD. Hence, we evaluated parameters renal tubular phosphorus handling their relation to prevailing FGF23 levels cohort young SCD patients. Methods Renal phosphate circulating various analytes including parathyroid (PTH) were...