A5090219957- Dialysis and Renal Disease Management
- Pediatric Urology and Nephrology Studies
- Regulation of Appetite and Obesity
- Birth, Development, and Health
- Adipose Tissue and Metabolism
- Nutrition and Health in Aging
- Diet and metabolism studies
- Chronic Kidney Disease and Diabetes
- Clinical Nutrition and Gastroenterology
- Biomedical Research and Pathophysiology
- COVID-19 Clinical Research Studies
- Parathyroid Disorders and Treatments
- Urological Disorders and Treatments
- Childhood Cancer Survivors' Quality of Life
- Electrolyte and hormonal disorders
- Renal function and acid-base balance
- Metabolism and Genetic Disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Neonatal Health and Biochemistry
- Erythrocyte Function and Pathophysiology
- Erythropoietin and Anemia Treatment
- Renal and related cancers
- Growth Hormone and Insulin-like Growth Factors
- Renal Diseases and Glomerulopathies
- Pancreatic function and diabetes
University of California, San Diego
2016-2025
Rady Children's Hospital-San Diego
2016-2025
Royal Stoke University Hospital
2024
Charité - Universitätsmedizin Berlin
2020
RELX Group (United States)
2017
Universidade Federal de Minas Gerais
2016
Capital Institute of Pediatrics
2016
Creative Research Enterprises (United States)
2016
University of California System
2015
Pediatrics and Genetics
1997-2012
The Schwartz formula was devised in the mid-1970s to estimate GFR children. Recent data suggest that this currently overestimates as measured by plasma disappearance of iohexol, likely a result change methods used measure creatinine. Here, we developed equations using from baseline visits 349 children (aged 1 16 yr) Chronic Kidney Disease Children (CKiD) cohort. Median iohexol-GFR (iGFR) 41.3 ml/min per 1.73 m(2) (interquartile range 32.0 51.7), and median serum creatinine 1.3 mg/dl. We...
An estimated 650,000 Americans will have ESRD by 2010. Young adults with kidney failure often develop progressive chronic disease (CKD) in childhood and adolescence. The Chronic Kidney Disease Children (CKiD) prospective cohort study of 540 children aged 1 to 16 yr GFR between 30 75 ml/min per 1.73 m2 was established identify novel risk factors for CKD progression; the impact function decline on growth, cognition, behavior; evolution cardiovascular factors. Annually, a physical examination...
The pathogenesis of cachexia in patients with uremia is unknown. We tested the hypothesis that uremia-associated caused by leptin signaling through hypothalamic melanocortin receptor 4 (MC4-R). performed either subtotal nephrectomy (N) or sham operations WT, receptor–deficient (db/db), and MC4-R knockout (MC4-RKO) mice. animals were on 17% protein diets, none uremic acidotic. WT-N mice produced a classic syndrome characterized decreased food intake, increased metabolic rate, loss lean body...
Background and objectives Metabolic abnormalities cardiovascular disease (CVD) risk factors have rarely been systematically assessed in children with chronic kidney (CKD). We examined the prevalence of various CKD sequelae across GFR spectrum. Design, setting, participants, & measurements Data were used from 586 participating Chronic Kidney Disease Children (CKiD) study (United States Canada) measured by iohexol plasma disappearance. Laboratory values CVD compared categories an age-,...
Proteinuria is associated with chronic kidney disease (CKD), and heavy proteinuria predicts a rapid decline in function. However, the epidemiologic distribution of this important biomarker study not well described pediatric CKD population.This cross-sectional North American children examined association among baseline clinical variables cohort. Urinary protein-to-creatinine ratios (Up/c) were used to measure level proteinuria.Of 419 subjects studied, median GFR as measured by iohexol...
Background and objectives The role of albuminuria as an indicator progression has not been investigated in children with CKD the absence diabetes. Design, setting, participants, & measurements Children were enrolled from 49 centers study between January 2005 March 2014. Cross-sectional multivariable linear regression ( n =647) was used to examine relationship urine protein-to-creatinine (UP/C [milligrams per milligram]) albumin-to-creatinine (ACR gram]) eGFR (milliliters minute 1.73 m 2...