Donald J. Weaver
A5070294363- Renal Diseases and Glomerulopathies
- Blood Pressure and Hypertension Studies
- Dialysis and Renal Disease Management
- Chronic Kidney Disease and Diabetes
- Renal function and acid-base balance
- Hemodynamic Monitoring and Therapy
- Complement system in diseases
- Birth, Development, and Health
- Nutritional Studies and Diet
- Vasculitis and related conditions
- Central Venous Catheters and Hemodialysis
- COVID-19 Clinical Research Studies
- Hormonal Regulation and Hypertension
- Immune Cell Function and Interaction
- Renal Transplantation Outcomes and Treatments
- Sodium Intake and Health
- Electrolyte and hormonal disorders
- Immunotherapy and Immune Responses
- SARS-CoV-2 and COVID-19 Research
- Gout, Hyperuricemia, Uric Acid
- Abdominal vascular conditions and treatments
- Obesity, Physical Activity, Diet
- Cardiovascular Health and Disease Prevention
- Poisoning and overdose treatments
- Immune Response and Inflammation
Levine Children's Hospital
2014-2024
Wake Forest University
2023
The University of Melbourne
2020
Austin Health
2020
Peninsula Health
2020
Eastern Health
2016-2020
Monash Health
2016-2020
Monash University
2016-2020
University of Glasgow
2016-2020
Australian Catholic University
2020
Abstract We have recently demonstrated that dendritic cells (DC) prepared from nonobese diabetic (NOD) mice, a spontaneous model for insulin-dependent diabetes mellitus, exhibit elevated levels of NF-κB activation upon stimulation. In the current study, we investigated influence dysregulation on APC function bone marrow-derived DC NOD vs BALB/c and diabetes-resistant mice. pulsed with either peptide or virus were found to be more efficient than at stimulating in vitro naive Ag-specific CD8+...
C5a is a proinflammatory mediator that has recently been shown to regulate adaptive immune responses. Here we demonstrate receptor (C5aR) signaling in DC affects the development of Treg and Th17 cells. Genetic ablation or pharmacological targeting C5aR spleen-derived results increased production TGF-beta leading de novo differentiation Foxp3(+) within 12 h after co-incubation with CD4(+) T cells from DO11.10/RAG2(-/-) mice. Stimulation C5aR(-/-) OVA TLR2 ligand Pam(3)CSK(4) induced high...
The Cure Glomerulonephropathy Network (CureGN) is a 66-center longitudinal observational study of patients with biopsy-confirmed minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy, or IgA nephropathy (IgAN), including vasculitis (IgAV). This describes the clinical characteristics and treatment patterns in cohort, comparisons between IgAN versus IgAV adult pediatric patients.Patients diagnostic kidney biopsy within 5 years screening were eligible to join...
Background Children are recognised as at lower risk of severe COVID-19 compared with adults, but the impact immunosuppression is yet to be determined. This study aims describe clinical course in children kidney disease taking immunosuppressive medication and assess severity. Methods Cross-sectional hosted by European Rare Kidney Disease Reference Network supported European, Asian International paediatric nephrology societies. Anonymised data were submitted online for any child (age <20...
Abstract Insulin-dependent diabetes mellitus (IDDM) is characterized by the T cell-mediated destruction of insulin-producing β cells. Accordingly, APCs, such as macrophage, have also been shown to be important in disease process. However, role(s) dendritic cells (DCs) that exhibit potent APC function remains undefined IDDM. Here we demonstrate DCs derived from nonobese diabetic (NOD) mice, a model for IDDM, are more sensitive various forms stimulation compared with those C57BL/6 and BALB/c...
Abstract In this study, we have investigated the use of plasmid DNA (pDNA) vaccination to elicit Th2 effector cell function in an Ag-specific manner and turn prevent insulin-dependent diabetes mellitus (IDDM) nonobese diabetic (NOD) mice. pDNA recombinants were engineered encoding a secreted fusion protein consisting fragment glutamic acid decarboxylase 65 (GAD65) linked IgGFc, IL-4. Intramuscular injection GAD65-IgGFc IL-4 effectively prevented NOD mice treated at early or late preclinical...
Adult and pediatric patients with ESRD have impaired maximum oxygen consumption (VO2 max), a reflection of the cardiopulmonary system's ability to meet increased metabolic demands. We sought determine factors associated decreased VO2 max in different stages CKD. was measured using standardized exercise testing protocol stage 2 4 chronic kidney disease (CKD) (n = 46), renal transplant recipients 22), treated maintenance hemodialysis 12), age-matched healthy controls 33). similar between...
Background Cardiovascular disease is a major cause of morbidity and mortality in children with chronic kidney disease. We sought to determine the prevalence cardiovascular risk factors glomerular describe current practice patterns regarding factor identification management. Methods Results Seven-hundred sixty-one aged 0 17 years any 4 biopsy-confirmed primary diseases (minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy, IgA nephropathy/vasculitis) were...
Abstract We previously demonstrated that administration of plasmid DNAs (pDNAs) encoding IL-4 and a fragment glutamic acid decarboxylase 65 (GAD65) fused to IgGFc induces GAD65-specific Th2 cells prevents insulin-dependent diabetes mellitus (IDDM) in nonobese diabetic (NOD) mice. To assess the general applicability pDNA vaccination mediate Ag-specific immune deviation, we examined immunotherapeutic efficacy recombinants murine insulin A B chains IgGFc. Insulin was chosen based on studies...
Abstract MMF is commonly prescribed following kidney transplantation, yet its use complicated by leukopenia. Understanding the genetics mediating this risk will help clinicians administer safely. We evaluated 284 patients under 21 years of age for incidence and time course ‐related leukopenia performed a candidate gene association study comparing frequency 26 SNP s between cases with controls. matched induction, steroid duration, race, center, age. also impact induction on to in all cases....
The reclassification of membranoproliferative glomerulonephritis (MPGN) into immune-complex MPGN (IC-MPGN) and C3 glomerulopathy (C3G) has provided insights 2 distinct diseases. Although outcomes in adults are poor both diseases, the pediatric literature is scarce limited to small, single-center cohorts.We conducted a retrospective analysis 165 patients across 17 hospitals compare between children with IC-MPGN C3G.Forty-two percent initially diagnosed were reclassified as C3G after review...