Myda Khalid
A5077255598- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Vasculitis and related conditions
- Complement system in diseases
- Escherichia coli research studies
- Autoimmune Bullous Skin Diseases
- Platelet Disorders and Treatments
- Renal Transplantation Outcomes and Treatments
- SARS-CoV-2 and COVID-19 Research
- Dialysis and Renal Disease Management
- Pregnancy and Medication Impact
- Genomics and Rare Diseases
- COVID-19 Clinical Research Studies
- Ion Transport and Channel Regulation
- Neonatal Health and Biochemistry
- Adolescent and Pediatric Healthcare
- BRCA gene mutations in cancer
- Tuberous Sclerosis Complex Research
- Renal and related cancers
- Celiac Disease Research and Management
- Acute Kidney Injury Research
- Vascular anomalies and interventions
- Renal and Vascular Pathologies
- Blood Coagulation and Thrombosis Mechanisms
- Ovarian cancer diagnosis and treatment
Indiana University School of Medicine
2018-2025
Riley Hospital for Children
2016-2025
Indiana University
2018-2025
Indiana University – Purdue University Indianapolis
2016-2024
Indiana University Bloomington
2024
Indiana University Health
2016-2024
Harvard University
2012-2018
Boston Children's Hospital
2012-2018
Understanding the mechanisms that regulate nephron progenitors during kidney development should aid of therapies for renal failure. MicroRNAs, which modulate gene expression through post-transcriptional repression specific target mRNAs, contribute to differentiation stem cells, but their role in nephrogenesis is incompletely understood. Here, we found loss miRNAs results a premature depletion this population development. Increased apoptosis and pro-apoptotic protein Bim accompanied...
The Cure Glomerulonephropathy Network (CureGN) is a 66-center longitudinal observational study of patients with biopsy-confirmed minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy, or IgA nephropathy (IgAN), including vasculitis (IgAV). This describes the clinical characteristics and treatment patterns in cohort, comparisons between IgAN versus IgAV adult pediatric patients.Patients diagnostic kidney biopsy within 5 years screening were eligible to join...
Prior cross-sectional studies suggest that health-related quality of life (HRQOL) worsens with more severe glomerular disease. This longitudinal analysis was conducted to assess changes in HRQOL changing disease status.Cure Glomerulonephropathy (CureGN) is a cohort patients minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy, IgA vasculitis, or nephropathy. assessed at enrollment and follow-up visits 1 3 times annually for up 5 years the Patient-Reported...
Background: Identifying patients with IgA Nephropathy at risk for disease progression is critical clinical decision making, risk-based patient counseling, and optimal enrollment of trials. Methods: Patients (IgAN) Vasculitis Nephritis (IgAVN) were enrolled in CureGN, a multi-center observational cohort study. Children adults analyzed separately four cohorts 1) full, 2) incident, 3) prevalent, 4) histology. Groups defined using latent class trajectory modeling proteinuria measurements over...
Epigenetic regulation of gene expression has a crucial role allowing for the self-renewal and differentiation stem progenitor populations during organogenesis. The mammalian kidney maintains population self-renewing cells that differentiate to give rise thousands nephrons, which are functional units carry out filtration maintain physiological homeostasis. polycomb repressive complex 2 (PRC2) epigenetically represses development by placing H3K27me3 mark on histone H3 at promoter enhancer...
Background and objectives There is renewed interest in adrenocorticotropic hormone (ACTH) for the treatment of nephrotic syndrome. We evaluated efficacy safety ACTH children with frequently relapsing or steroid-dependent syndrome a randomized trial. Design, setting, participants, & measurements Participants aged 2–20 years old were enrolled from 16 sites United States 1:1 to (repository corticotropin injection) no relapse-preventing treatment. regimen was 80 U/1.73 m 2 administered twice...
The 2012 Kidney Disease: Improving Global Outcomes (KDIGO) Clinical Practice Guidelines for Glomerulonephritis recommend that patients with membranous nephropathy (MN) at risk progression receive immunosuppressive therapy (IST), usually after 6 months of observation. A cyclophosphamide (CYC) or calcineurin inhibitor (CNI)-based regimen is recommended as first-line IST. However, the extent to which KDIGO recommendations are adopted in practice remains largely unknown.We evaluated prescribing...
A precision health initiative was implemented across a multi-hospital system, wherein panel of genetic variants tested and utilized in the clinical care chronic kidney disease (CKD) patients. Pharmacogenomic predictors antihypertensive response genomic CKD were provided to clinicians caring for nephrology To assess clinician knowledge, attitudes, willingness act on testing results, Likert-scale survey sent self-administered by these providers (N = 76). Most respondents agreed that utilizing...
<b><i>Introduction:</i></b> Disparities in health-related quality of life (HRQOL) have been inadequately studied patients with glomerular disease. The aim this study was to identify relationships among race/ethnicity, socioeconomic status, disease severity, and HRQOL an ethnically racially diverse cohort <b><i>Methods:</i></b> Cure Glomerulonephropathy (CureGN) is a multinational biopsy-proven Associations between race/ethnicity were determined...
Abstract Background There is a lack of evidence to suggest that outcomes adolescent and adult-onset glomerular disease differ. Still, most trials include adults but exclude adolescents. Methods We designed retrospective study using the CureGN database compare individuals with adolescent-onset relative older younger age at onset. The two main were sustained proteinuria remission off immunosuppression treatment composite eGFR decline. Results Our data did not show significant difference in or...
Hemolytic uremic syndrome (HUS) is a life-threatening complication of Shiga toxin-producing Escherichia coli (STEC) infection. The relationship between STEC exposure and severity clinical outcomes not well documented. We examined whether direct contact with farm animals increased the likelihood HUS among Indiana residents diagnosed STEC.Exposure data for laboratory-confirmed cases during 2012-2018 were retrieved. Logistic regression mediation analysis performed to determine extent which...
Background: The occurrence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and associated disease 2019 (COVID-19) have profoundly affected adult kidney patients. In contrast, pediatric solid organ transplant recipients, including (KT) do not seem to be at particularly higher risk for SARS-CoV-2 infection or COVID-19 disease. This patient population might protected by certain mechanisms, such as immunosuppressive medications with their anti-inflammatory properties simply...
IntroductionPrimary membranous nephropathy (PMN) is uncommon in children. Therefore, data on the clinical course of affected children are scarce. In recent years, several novel antigens have been implicated pathogenesis PMN. However, histopathologic characteristics pediatric patients with PMN remain poorly represented literature.MethodsWe retrospectively analyzed presentation and outcomes 21 from 3 centers United States. addition, we identified biopsy specimens these correlated their...
Rationale & ObjectiveCardiovascular (CV) and thromboembolic (TE) events are known complications of glomerular disease (GD), but their incidence risk factors poorly characterized. This analysis describes CV TE outcomes in the Cure GlomeruloNephropathy (CureGN) Network.Study DesignProspective cohort study.Setting ParticipantsCureGN is a prospective study children adults with biopsy-proven minimal change (MCD), focal segmental glomerulosclerosis (FSGS), membranous nephropathy (MN), or IgA...