Zubin J. Modi
A5066854543- Dialysis and Renal Disease Management
- Chronic Kidney Disease and Diabetes
- Renal and Vascular Pathologies
- Renal Diseases and Glomerulopathies
- Adolescent and Pediatric Healthcare
- Healthcare cost, quality, practices
- Hormonal Regulation and Hypertension
- Blood Pressure and Hypertension Studies
- Acute Kidney Injury Research
- Renal cell carcinoma treatment
- Abdominal vascular conditions and treatments
- Pediatric Urology and Nephrology Studies
- Genetic and Kidney Cyst Diseases
- Vascular anomalies and interventions
- Birth, Development, and Health
- Social Media in Health Education
- Adrenal Hormones and Disorders
- Clinical Laboratory Practices and Quality Control
- Diversity and Career in Medicine
- Health, Environment, Cognitive Aging
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Anesthesia and Neurotoxicity Research
- Congenital heart defects research
- Nutrition, Health and Food Behavior
- COVID-19 Impact on Reproduction
University of Michigan
2009-2025
Michigan Medicine
2022-2024
Michigan United
2009-2024
C. S. Mott Children's Hospital
2023
The Centers
2021
<h3>Importance</h3> Cardiovascular disease (CVD) is a leading cause of death among patients with end-stage renal (ESRD). Young adult (ages 22-29 years) have risks for ESRD-associated CVD that may vary from other ages. <h3>Objective</h3> To test the hypothesis young adult–onset ESRD associated higher cardiovascular (CV) hospitalizations and mortality different characteristics than childhood-onset disease. <h3>Design, Setting, Participants</h3> This population-based cohort study used US Renal...
Glomerular diseases are classified using a descriptive taxonomy that is not reflective of the heterogeneous underlying molecular drivers. This limits only diagnostic and therapeutic patient management, but also impacts clinical trials evaluating targeted interventions. The Nephrotic Syndrome Study Network (NEPTUNE) poised to address these challenges. study has enrolled >850 pediatric adult patients with proteinuric glomerular who have contributed deep clinical, histologic, genetic, profiles...
Insulin-like growth factors (IGFs) are key regulators of development, growth, and longevity. In most vertebrate species including humans, there is one IGF-1 gene IGF-2 gene. Here we report the identification functional characterization 4 distinct IGF genes (termed as igf-1a, -1b, -2a, -2b) in zebrafish. These encode structurally peptides. IGF-1a IGF-2a mRNAs were detected multiple tissues adult fish. IGF-1b mRNA was only gonad IGF-2b liver. Functional analysis showed that all IGFs caused...
Significant racial and ethnic disparities in chronic kidney disease (CKD) progression outcomes are well documented, as is low use of guideline-recommended CKD care.To examine care delivery by race ethnicity a large, diverse population.In this serial cross-sectional study, adult patients with that did not require dialysis, defined persistent estimated glomerular filtration rate less than 60 mL/min/1.73 m2 or urine albumin-creatinine ratio 30 mg/g higher for at least 90 days, were identified...
The goal of this study was to assess the occurrence steroid-associated adverse events (SAAE) in patients with primary proteinuric kidney disease.The Kidney Research Network Registry consists children and adults disease. SAAEs interest were hypertension, hyperglycemia diabetes, overweight obesity, short stature, ophthalmologic complications, bone disorders, infections, psychosis. Events identified using International Classification Diseases, Ninth Revision/Tenth Revision codes, blood...
Importance It remains unclear whether children and adolescents with SARS-CoV-2 infection are at heightened risk for long-term kidney complications. Objective To investigate is associated an increased of postacute outcomes among pediatric patients, including those preexisting disease or acute injury (AKI). Design, Setting, Participants This retrospective cohort study used data from 19 health institutions in the National Institutes Health Researching COVID to Enhance Recovery (RECOVER)...
Pediatric patients with complex medical problems benefit from pediatric sub-specialty care; however, a significant proportion of children live greater than 80 mi. away care.
Focal segmental glomerulosclerosis (FSGS) and treatment-resistant minimal change disease (TR-MCD) are heterogeneous disorders with subgroups defined by distinct underlying mechanisms of glomerular tubulointerstitial injury. A non-invasive urinary biomarker profile has been generated to identify patients intra-kidney tumor necrosis factor (TNF)-activation predict response anti-TNF treatment. We conducted this proof-of-concept, multi-center, open-label clinical trial test the hypothesis that...
Abstract Background There is considerable state-level variation in the incidence of dialysis-requiring acute kidney injury (AKI-D). However, little known about reasons for this geographic variation. Methods National cross-sectional ecological study based on State Inpatient Databases (SID) and Behavioral Risk Factor Surveillance System (BRFSS) 2011. We analyzed 18 states six chronic health conditions (diabetes mellitus [diabetes], hypertension, disease [CKD], arteriosclerotic heart [ASHD],...
We investigated the risks of post-acute and chronic adverse kidney outcomes SARS-CoV-2 infection in pediatric population via a retrospective cohort study using data from RECOVER program. included 1,864,637 children adolescents under 21 19 children's hospitals health institutions US with at least six months follow-up time between March 2020 May 2023. divided patients into three strata: pre-existing disease (CKD), acute injury (AKI) during phase (within 28 days) infection, without CKD or AKI....