Jiajie Chen
A5103006568- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- COVID-19 and Mental Health
- Intensive Care Unit Cognitive Disorders
- Respiratory Support and Mechanisms
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Impact on Reproduction
- Infectious Encephalopathies and Encephalitis
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Thermal Regulation in Medicine
- Liver Disease and Transplantation
- Kawasaki Disease and Coronary Complications
- Bacterial Infections and Vaccines
- Renal function and acid-base balance
- Pediatric Pain Management Techniques
- Multiple Sclerosis Research Studies
- Climate Change and Health Impacts
- Respiratory viral infections research
- Congenital Diaphragmatic Hernia Studies
- Acute Kidney Injury Research
- Resilience and Mental Health
University of Pennsylvania
2024-2025
California University of Pennsylvania
2024-2025
University of Florida Health
2023
The efficacy of the BNT162b2 vaccine in pediatrics was assessed by randomized trials before Omicron variant's emergence. long-term durability protection this population during period remains limited.
Importance The profile of gastrointestinal (GI) tract outcomes associated with the postacute and chronic phases COVID-19 in children adolescents remains unclear. Objective To investigate risks GI symptoms disorders during (28-179 days after documented SARS-CoV-2 infection) (180-729 pediatric population. Design, Setting, Participants This retrospective cohort study was performed from March 1, 2020, to September 2023, at 29 US health care institutions. included patients 18 years or younger...
Importance Obesity is associated with increased severity of COVID-19. Whether obesity an risk post-acute sequelae SARS-CoV-2 infection (PASC) among pediatric populations, independent its association acute severity, unclear. Objective To quantify the body mass index (BMI) status before PASC risk, controlling for severity. Design, Setting, and Participants This retrospective cohort study occurred at 26 US children’s hospitals from March 2020 to May 2023 a minimum follow-up 179 days. Eligible...
The COVID-19 pandemic has been associated with increased neuropsychiatric conditions in children and youths, evidence suggesting that SARS-CoV-2 infection may contribute additional risks beyond stressors. This study aimed to assess the full spectrum of positive (ages 5-12) youths 12-20) compared a matched negative cohort, accounting for factors influencing risk. Using EHR data from 25 institutions RECOVER program, we conducted retrospective analysis 326,074 887,314 participants risk...
Racial/ethnic differences are associated with the symptoms and conditions of post-acute sequelae SARS-CoV-2 infection (PASC) in adults. These may exist among children warrant further exploration. We conducted a retrospective cohort study difference-in-differences analyzes to assess these adolescents under age 21. The utilized data from RECOVER Initiative United States, which aims learn about long-term effects COVID-19. included 225,723 patients or COVID-19 diagnosis between March 2020...
Abstract IMPORTANCE Prior studies have demonstrated the effectiveness of COVID-19 vaccines in children and adolescents. However, benefits vaccination these age groups with prior infection remain underexplored. OBJECTIVE To evaluate preventing reinfection various Omicron subvariants (BA.1/2, BA.4/5, XBB, later) among 5- to 17-year-olds SARS-CoV-2 infection. DESIGN A target trial emulation through nested designs distinct study periods. SETTING The utilized data from Research COVID Enhance...
Abstract IMPORTANCE Nirmatrelvir-ritonavir, an efficacious treatment for acute COVID-19, has yielded conflicting evidence regarding its effectiveness in preventing Long COVID among adults. The of nirmatrelvir-ritonavir adolescents real-world settings is not well understood. OBJECTIVE To evaluate the aged 12 to 20 years given within first five days COVID-19 illness on severity during (days 0 27) and post-acute phases 28 179). DESIGN, SETTING, AND PARTICIPANTS This target trial emulation used...
Importance It remains unclear whether children and adolescents with SARS-CoV-2 infection are at heightened risk for long-term kidney complications. Objective To investigate is associated an increased of postacute outcomes among pediatric patients, including those preexisting disease or acute injury (AKI). Design, Setting, Participants This retrospective cohort study used data from 19 health institutions in the National Institutes Health Researching COVID to Enhance Recovery (RECOVER)...
Abstract Background The risk of cardiovascular outcomes in the post-acute phase SARS-CoV-2 infection has been quantified among adults and children. This paper aimed to assess a multitude cardiac signs, symptoms, conditions, as well focused on patients with without congenital heart defects (CHDs), provide more comprehensive assessment children adolescents after COVID-19. Methods retrospective cohort study used data from RECOVER consortium comprising 19 US children’s hospitals health...
The efficacy of the BNT162b2 vaccine in pediatrics was assessed by randomized trials before Omicron variant's emergence. long-term durability protection this population during period remains limited.
Background: Racial/ethnic differences are associated with the potential symptoms and conditions of post-acute sequelae SARS-CoV-2 infection (PASC) in adults. These may exist among children warrant further exploration. Methods: We conducted a retrospective cohort study for adolescents under 21 from thirteen institutions RECOVER Initiative within United States. The is 225,723 patients or COVID-19-related diagnosis 677,448 without COVID-19 between March 2020 October 2022 at least 6 months...
Abstract Racial/ethnic differences are associated with the potential symptoms and conditions of post-acute sequelae SARS-CoV-2 infection (PASC) in adults. These may exist among children warrant further exploration. We conducted a retrospective cohort study for adolescents under age 21 from thirteen institutions RECOVER Initiative. The is 225,723 patients or COVID-19 diagnosis 677,448 without between March 2020 October 2022. compared minor racial/ethnic groups to Non-Hispanic White (NHW)...
Background: The impact of COVID-19 on gastrointestinal (GI) outcomes in children during the post-acute and chronic phases disease is not well understood.Methods: We conducted a retrospective cohort study across twenty-nine healthcare institutions from March 2020 to September 2023, including 413,455 pediatric patients with confirmed SARS-CoV-2 infection 1,163,478 controls without infection. Infection was via polymerase chain reaction (PCR), serology, antigen tests, or clinical diagnosis...
Abstract Importance The profile of gastrointestinal (GI) outcomes that may affect children in post-acute and chronic phases COVID-19 remains unclear. Objective To investigate the risks GI symptoms disorders during phase (28 days to 179 after SARS-CoV-2 infection) (180 729 pediatric population. Design We used a retrospective cohort design from March 2020 Sept 2023. Setting twenty-nine healthcare institutions. Participants A total 413,455 patients aged not above 18 with infection 1,163,478...
Abstract IMPORTANCE Obesity increases the severe COVID-19 risk. Whether obesity is associated with an increased risk of post-acute sequelae SARS-Cov-2 infection (PASC) among pediatrics, independent its impacts on acute severity, unclear. OBJECTIVE To quantify association between body mass index (BMI) status before SARS-CoV-2 and pediatric PASC risk, controlling for severity. DESIGN Retrospective cohort study occurred from March 2020 to May 2023, a minimal follow-up 179 days. SETTING...
We investigated the risks of post-acute and chronic adverse kidney outcomes SARS-CoV-2 infection in pediatric population via a retrospective cohort study using data from RECOVER program. included 1,864,637 children adolescents under 21 19 children's hospitals health institutions US with at least six months follow-up time between March 2020 May 2023. divided patients into three strata: pre-existing disease (CKD), acute injury (AKI) during phase (within 28 days) infection, without CKD or AKI....
Abstract Background The impact of pre-infection vaccination on the risk long COVID remains unclear in pediatric population. Further, it is unknown if such can mitigate beyond its established protective benefits against SARS-CoV-2 infection. Objective To assess effectiveness BNT162b2 risks with various strains virus children and adolescents, using comparative methods. disentangle overall vaccine outcomes into independent indirect via prevention infections, causal mediation analysis. Design...