A5102014394- Air Quality and Health Impacts
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Respiratory Support and Mechanisms
- Immune Response and Inflammation
- Occupational and environmental lung diseases
- Sepsis Diagnosis and Treatment
- Immune cells in cancer
- Osteoarthritis Treatment and Mechanisms
- Climate Change and Health Impacts
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- Acute Ischemic Stroke Management
- Silk-based biomaterials and applications
- Knee injuries and reconstruction techniques
- Electrospun Nanofibers in Biomedical Applications
- Nosocomial Infections in ICU
- ZnO doping and properties
- Nerve injury and regeneration
- Heme Oxygenase-1 and Carbon Monoxide
- Sport and Mega-Event Impacts
- Ultrasound in Clinical Applications
- Traumatic Brain Injury and Neurovascular Disturbances
- Regional Economic and Spatial Analysis
- Advanced Memory and Neural Computing
NYU Langone Health
2019-2025
Nanjing Medical University
2025
New York University
2020-2025
Huazhong University of Science and Technology
2015-2024
California University of Pennsylvania
2024
Fujian Medical University
2024
Tongji Hospital
2020-2024
University of Pennsylvania
2024
Guangdong Academy of Medical Sciences
2024
Guangdong Provincial People's Hospital
2024
The global numbers of confirmed cases and deceased critically ill patients with COVID-19 are increasing. However, the clinical course, 60-day mortality its predictors in have not been fully elucidated. aim this study is to identify COVID-19. Critically adult admitted intensive care units (ICUs) from 3 hospitals Wuhan, China, were included. Data on demographic information, preexisting comorbidities, laboratory findings at ICU admission, treatments, outcomes, results SARS-CoV-2 RNA tests serum...
It has been shown that light speckle fluctuations provide a means for noninvasive measurements of cerebral blood flow index (CBFi). While conventional Diffuse Correlation Spectroscopy (DCS) provides marginal brain sensitivity CBFi in adult humans, new techniques have recently emerged to improve diffuse throughput and thus, sensitivity. Here we further optimize one such approach, interferometric diffusing wave spectroscopy (iDWS), with respect number independent channels, camera duty cycle...
A mussel-inspired cryogel functionalized with near-infrared light-responsive polydopamine nanoparticles is developed for accelerating wound healing.
Hyponatremia occurs in up to 30% of patients with pneumonia and is associated increased morbidity mortality. The prevalence hyponatremia coronavirus disease 2019 the impact on outcome unknown. We aimed identify prevalence, predictors, mild, moderate, severe admission compared normonatremia among patients.
Following spinal cord injury (SCI), the transmission of electrical signals is interrupted, and an oxidative microenvironment generated, hindering nerve regeneration functional recovery. The strategies regulating pathological while restoring endogenous signal hold promise for SCI treatment. However, challenges are still faced in simply fabricating bioactive scaffolds with both antioxidation conductivity. Herein, aiming to construct antioxidative conductive regeneration, difunctional...
Impairment of innate immune cell function and metabolism underlies immunosuppression in sepsis; however, a promising therapy to orchestrate this impairment is currently lacking. In study, high levels NOD-like receptor family CARD domain containing-3 (NLRC3) correlated with the glycolytic defects monocytes/macrophages from septic patients mice that developed immunosuppression. Myeloid-specific NLRC3 deletion improved macrophage glycolysis sepsis-induced Mechanistically, inhibits nuclear...
Aim We investigated the mechanisms by which N1-(β-d-ribofuranosyl)-5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), an activator of AMP-activated protein kinase (AMPK), decreases lung injury and mortality when administered to mice post exposure bromine gas (Br 2 ). Methods exposed male C57BL/6 heme oxygenase-1 (HO-1)-deficient (HO-1 −/− ) corresponding wild-type (WT) littermate Br (600 ppm for 45 or 30 min, respectively) in environmental chambers returned them room air. AICAR was 6 h...
Background: Invasive pulmonary aspergillosis (IPA) is a life-threatening complication in coronavirus disease 2019 (COVID-19) patients admitted to intensive care units (ICUs), but risk factors for COVID-19-associated IPA (CAPA) have not been fully characterized. The aim of the current study was identify associated with CAPA, and assess long-term mortality. Methods: A retrospective cohort adult COVID-19 ICUs from six hospitals conducted Hubei, China. CAPA diagnosed via composite clinical...
Intensive care unit (ICU)-acquired infection is a common cause of poor prognosis sepsis in the ICU. However, sepsis-associated ICU-acquired infections have not been fully characterized. The study aims to assess risk factors and develop model that predicts patients with sepsis. Methods We retrieved data from Medical Information Mart for Care (MIMIC) IV database. Patients were randomly divided into training validation cohorts at 7:3 ratio. A multivariable logistic regression was used identify...
The repair of cartilage damage caused by trauma, wear, or degenerative deformation remains a major challenge in modern medicine. Therefore, it is essential to develop mechanically compatible and bioactive scaffold for tissue regeneration. In this study, mussel-inspired, tough, adhesive polydopamine/gelatin-poly(acrylic acid) (PDA/Gel-PAA) composite hydrogel was developed achieved high compressive strength up 0.67 MPa toughness 420 J/m2 because the unique chemical-physical cross-linking...
Pulmonary fibrosis is a major cause of the poor prognosis acute respiratory distress syndrome (ARDS). While mechanical ventilation (MV) an indispensable life-saving intervention for ARDS, it may remodeling process in lung epithelial cells to become disorganized and exacerbate ARDS-associated pulmonary fibrosis. Piezo1 mechanosensitive ion channel that known play role regulating diverse physiological processes, but whether necessary MV-exacerbated remains unknown.This study aimed explore...
Amyloid-β (Aβ) peptide, which can invoke a cascade of inflammatory responses, is considered to play causal role in the development and progress Alzheimer's disease (AD). Xylocoside G (XG) an active compound isolated from traditional Chinese
The surveillance of infectious diseases is great importance for disease control and prevention, more attention should be paid to the Class B notifiable in China. Meanwhile, according International Monetary Fund (IMF), annual growth Chinese gross domestic product (GDP) would decelerate below 7% after many years soaring. Under such circumstances, this study aimed answer what will happen incidence rates China if GDP remained next five years. Firstly, time plots cross-correlation matrices were...
Malignant glioma is the most common primary brain tumor in adults and has a poor prognosis. However, there are no effective targeted therapies for patients. Thus, development of novel therapeutics urgently needed. In this study, we examined prognostic significance BTK expression patients with glioma. Furthermore, investigated mechanism therapeutic potential ibrutinib treatment human vitro vivo. Our data demonstrate that high marker survival BTK-specific inhibitor effectively inhibits...
Mechanical ventilation-induced pulmonary fibrosis plays an important role in the high mortality rate of acute respiratory distress syndrome (ARDS). Resolvin D1 (RvD1) displays potent proresolving activities. Epithelial-mesenchymal transition (EMT) has been proved to be pathological feature lung fibrosis. This study aimed investigate whether RvD1 can attenuate mechanical Human epithelial (BEAS-2B) cells were pretreated with for 30 min and exposed acid 10 before being subjected stretch 48 h....