A5101420236- Respiratory Support and Mechanisms
- Neonatal Respiratory Health Research
- Anesthesia and Neurotoxicity Research
- Cardiac Ischemia and Reperfusion
- Fatty Acid Research and Health
- Pain Mechanisms and Treatments
- Intensive Care Unit Cognitive Disorders
- Eicosanoids and Hypertension Pharmacology
- Anesthesia and Sedative Agents
- Immune Response and Inflammation
- Thermal Regulation in Medicine
- Ferroptosis and cancer prognosis
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Cardiac Arrest and Resuscitation
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Inflammation biomarkers and pathways
- Heme Oxygenase-1 and Carbon Monoxide
- Neuropeptides and Animal Physiology
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Ion channel regulation and function
- Renal function and acid-base balance
- MicroRNA in disease regulation
- High Altitude and Hypoxia
- Cancer, Stress, Anesthesia, and Immune Response
Union Hospital
2016-2025
Huazhong University of Science and Technology
2016-2025
Union Hospital
2013-2025
University of Benin
2021
Jinan University
2014
Second Hospital of Shandong University
2007
Shandong Provincial Hospital
2007
Heritage Christian University
2006
Wuhan Union Hospital
2000
Blood-brain barrier (BBB) dysfunction may occur at the onset of Alzheimer's disease (AD). Pericytes are a vital part neurovascular unit and BBB, acting as gatekeepers BBB. Amyloid β (Aβ) deposition neurofibrillary tangles in brain central pathological features AD. CD36 promotes vascular amyloid leads to damage, dysfunction, cognitive deficits. However, molecular mechanism by which pericytes BBB disrupted remains unclear.To investigate effect low-dose Aβ1-40 administration on pericyte outcome...
In Brief BACKGROUND: We hypothesized that posttreatment with 15-epi-16-parafluoro-phenoxy lipoxin A4 (ATL) could attenuate lipopolysaccharide (LPS)-induced acute lung injury in mice. METHODS: All the animals were randomly assigned to one of six groups (n = 6 per group). sham-vehicle group, mice treated 0.9% saline 60 min after they challenged saline. The sham-ATL group was identical except ATL (0.7 mg/kg, IV) administered, and sham-ZnPP Zinc protoporphyrin IX (ZnPP, 25 mg/kg administered....
The COVID-19 (also named as 2019-nCoV) is a very contagious novel coronavirus. Though most patients contracted the 2019-nCoV will likely have mild symptoms with good prognosis, some develop severe acute respiratory infection, pneumonia, or distress syndrome. Some of these need anesthesia care for endotracheal intubation, critical management and surgical services. Perioperative services face enormous challenges in managing COVID-19. are how to protect perioperative providers avoid...
NOD-like receptor 3 (NLRP3) plays critical roles in the initiation of inflammasome-mediated inflammation microglia, thus becomes an important therapeutic target Alzheimer's disease (AD). Dexmedetomidine (Dex), a new type clinical anesthetic agent, shows anti-inflammatory properties and inhibits postoperative cognitive dysfunction AD patients. The present study was aimed to investigate effect Dex on NLRP3 activity activated microglia reveal underlying mechanisms. human clone (HMC3) cells were...
Recently, a serial of studies have demonstrated that lipid mediators derived from Omega-3 fatty acid docosahexaenoic pro-resolving or anti-inflammatory effects in many inflammatory diseases. Here, we sought to evaluate whether Protectin DX (PDX, an isomer Protecin D1), newly identified mediator, could protect mice against sepsis and explore the underling mechanism. Animal model was established by cecum ligation puncture (CLP). We found PDX increased overall survival rate within eight days...
Our study is the first to illustrate age and geographic distribution differences in epidemiology of prostate cancer from 1990 2019 China. Prostate (PC) a malignant tumor derived epithelial cells one most commonly diagnosed cancers men. In recent years, global incidence annual deaths number PC showed continuous increase, which has caused huge disease burden on human health. terms average, mortality China are relatively low. However, age-standardized rate was 17.3/100,000 China, with 95.2%...
Background A variety of inflammatory mediators and effector cells participate together in acute lung injury, lead to secondary injury that is due an cascade diffuse parenchyma injury. Inflammation associated with oxidative stress reaction, which produced the development airway inflammation, has positive feedback on inflammation itself. Resolvin D1 can reduce infiltration neutrophils, regulate cytokine levels thereby promote resolution inflammation. The purpose this study investigate effects...
Mechanical ventilation-induced pulmonary fibrosis plays an important role in the high mortality rate of acute respiratory distress syndrome (ARDS). Resolvin D1 (RvD1) displays potent proresolving activities. Epithelial-mesenchymal transition (EMT) has been proved to be pathological feature lung fibrosis. This study aimed investigate whether RvD1 can attenuate mechanical Human epithelial (BEAS-2B) cells were pretreated with for 30 min and exposed acid 10 before being subjected stretch 48 h....
The dysfunctional immune response and multiple organ injury in sepsis is a recurrent theme impacting prognosis mortality, while the lung first invaded by sepsis. To systematically elucidate transcriptomic changes main constituent cells of sepsis-injured tissue, we applied single-cell RNA sequencing to tissue samples from septic control mice created comprehensive cellular landscape with 25044 cells, including 11317 13727 non-immune cells. Sepsis alters composition all compartments,...
Abstract Significant individual susceptibility to intravenous anesthetic propofol exists. The etiology of variability in the response may be influenced by genetic polymorphisms metabolic and functional pathways. With current pharmacogenetics modern molecular biology technologies, it is possible study influence on propofol. When inducing general anesthesia with propofol, high was found. Using Sequenom MassARRAY single-nucleotide polymorphism (SNP) genotyping, we identified a mutation (rs6313)...
Lung fibrosis is an aggressive disease with uncontrolled fibrotic response and no effective therapeutic treatment. Epithelial-to-mesenchymal transition (EMT) has been proved to be important pathological feature in lung fibrosis. In this study, we investigated whether MaR1, a kind of proresolving lipid mediators, could inhibit TGF-β1-induced EMT vitro vivo. mouse type II alveolar epithelial cells were treated different does MaR1 for 30 min exposed TGF-β1 48 h. vivo C57BL/6 mice administered...
Heatstroke (HS) is typically considered a sepsis-like syndrome caused by hyperthermia, often accompanied multiple organ dysfunctions (MODS). To explore the mechanisms of MODS, we established mouse model HS exposing mice to hyperthermic and high-humidity environment. Then, utilized single-cell RNA sequencing (scRNA-seq) depict cellular landscape lung tissue liver tissue. We found that enhancement neutrophil infiltration mediated "Cxcr2-Cxcl2″ receptor-ligand pair prominent feature HS-induced...
The present study was conducted to determine whether the activation of TRESK in dorsal root ganglion (DRG) by gene recombinant adenovirus vector inhibits capsaicin-evoked substance P (SP) release using a radioimmunoassay. is an outwardly rectifying K+ current channel that contributes resting potential and most important background potassium DRG. Previous studies have shown neuropathic pain (NP) closely related regulation certain channels DRG neurons, while DRG-released SP peripheral...