A5100665329- Inflammasome and immune disorders
- Drug-Induced Hepatotoxicity and Protection
- Immune cells in cancer
- DNA Repair Mechanisms
- Cancer, Lipids, and Metabolism
- Cancer-related Molecular Pathways
- Ubiquitin and proteasome pathways
- Ferroptosis and cancer prognosis
- Sepsis Diagnosis and Treatment
- Liver Disease Diagnosis and Treatment
- TGF-β signaling in diseases
- Cancer Mechanisms and Therapy
- interferon and immune responses
- Fatty Acid Research and Health
- Pharmacological Effects of Natural Compounds
- Bone Metabolism and Diseases
- Cancer-related molecular mechanisms research
- Inflammation biomarkers and pathways
- PARP inhibition in cancer therapy
- Circular RNAs in diseases
- Natural Compounds in Disease Treatment
- Microbial Natural Products and Biosynthesis
- CAR-T cell therapy research
- Plant-derived Lignans Synthesis and Bioactivity
- Acute Kidney Injury Research
Huazhong University of Science and Technology
2016-2025
Union Hospital
2023-2025
Union Hospital
2016-2024
Dalian Medical University
2020-2023
Second Affiliated Hospital of Chongqing Medical University
2020-2023
Chongqing Medical University
2020-2023
University of Chicago Medical Center
2023
Molecular Oncology (United States)
2023
Institute of Genetics and Cancer
2020
University of Edinburgh
2020
Drugs, viruses, and chemical poisons stimulating live in a short period of time can cause acute liver injury (ALI). ALI further develop into serious diseases such as cirrhosis cancer. Therefore, how to effectively prevent treat has become the focus research. Numerous studies have reported Maresin1 (MaR1) anti-inflammatory effect protective functions on organs. In present study, we used d-galactosamine/lipopolysaccharide (D-GalN/LPS) establish an model, explored mechanism cells death caused...
Cuproptosis, a novel copper-induced cell death pathway, is linked to mitochondrial respiration and mediated by protein lipoylation. The discovery of cuproptosis unfolds new areas investigation, particularly in cancers. present study aimed explore the role colorectal cancer progression. genetic alterations colon were evaluated using database. MTT assays, colony formation, flow cytometry used examine effect elesclomol-Cu 4-Octyl itaconate (4-OI) on oxaliplatin-resistant viability. anti-tumor...
Maresin 1 (MaR 1) was recently reported to have protective properties in several different animal models of acute inflammation by inhibiting inflammatory response. However, its function liver injury is still unknown. To address this question, we induced BALB/c mice with intraperitoneal injection carbon tetrachloride or without treatment MaR 1. Our data showed that attenuated hepatic injury, oxidative stress, and lipid peroxidation tetrachloride, as evidenced increased thiobarbituric acid...
Abstract Oxaliplatin is widely used in chemotherapy for colorectal cancer (CRC), but its sensitivity has become a major obstacle to limiting efficacy. Many literatures reported that Nrf2 activation promoted tumor chemoresistance. In this study, we explored the role and mechanism of inhibition oxaliplatin-based chemosensitivity CRC. vitro experiments, applied 4-octyl itaconate (4-OI) activate Nrf2, lentivirus knock down CRC cell lines. By measuring viability, colony formation, apoptosis,...
The liver is an important metabolic organ, and acute injury (ALI) potentially lethal. Itaconate, a intermediate from the tricarboxylic acid cycle, showed emerging anti-oxidative anti-inflammation properties, accumulating protective effect in multiple diseases, but its role ALI still needs to be further explored. Here we established model induced by carbon tetrachloride mice. Our results that 4-Octyl itaconate (OI), derivate of itaconate, mitigated hepatic damage improving function, reducing...
Although PARP inhibitor (PARPi) has been proven to be a promising anticancer drug in cancer patients harboring BRCA1/2 mutation, it provides limited clinical benefit colorectal with low prevalence of mutations. In our study, we found PARPi talazoparib significantly induced cellular senescence via inhibiting p53 ubiquitination and activating p21. Furthermore, CDK4/6i palbociclib amplified this therapy-induced (TIS) vitro vivo. Mechanistically, combination senescence-associated secretory...
Background: Bromodomain-containing protein 4(BRD4) is reported to play a vital role in the development of numerous malignant diseases, which considered as promising target for cancer therapy.AZD5153, novel specific BRD4 inhibitor, showed potent anticancer effects several types, but its therapeutic potential has not been fully evaluated colorectal cells.Objective: We sought evaluate inhibition by AZD5153 and combined effect with PARP inhibitor BMN673 vitro vivo cancer.Methods: analyzed The...
Inflammatory bowel disease (IBD) is a chronic relapsing gastrointestinal disorder, while the treatment effect not satisfactory. Immune responsive gene 1 (IRG1) highly expressed in macrophage response to inflammatory and catalyzes production of itaconate. Studies have reported that IRG1/itaconate has significant antioxidant effect. This study aimed investigate mechanism on dextran sulfate sodium (DSS)-induced colitis vivo vitro. In experiments, we found exerted protective effects against...
Lung fibrosis is an aggressive disease with uncontrolled fibrotic response and no effective therapeutic treatment. Epithelial-to-mesenchymal transition (EMT) has been proved to be important pathological feature in lung fibrosis. In this study, we investigated whether MaR1, a kind of proresolving lipid mediators, could inhibit TGF-β1-induced EMT vitro vivo. mouse type II alveolar epithelial cells were treated different does MaR1 for 30 min exposed TGF-β1 48 h. vivo C57BL/6 mice administered...
The phosphoinositide 3-kinase/Akt pathway activation commonly occurs in various types of human cancer and has an important role chemoresistance. Combination traditional chemotherapy drugs molecular-targeted agents is a promising strategy for therapy, which shown enhanced cytotoxicity lower drug resistance. present study found that the Akt inhibitor, MK-2206, can increase effect cisplatin gastric cell line AGS, higher phosphorylation, but exhibited poor combination MKN-45 MGC-803 cells, have...
Monoacylglycerol lipase (MAGL) is involved in the degradation of triacylglycerol. Previous studies have demonstrated that MAGL regulates tumor growth and metastasis via fatty acid networks, associated with colorectal cancer. JZL184 a inhibitor, which present study was administered to cancer cell lines, resulting decreased proliferation, increased apoptosis sensitivity 5-fluorouracil. B‑cell lymphoma 2 (Bcl‑2) Bcl‑2‑associated X protein (Bax) are key proteins apoptosis. The expression levels...
Identification of genomic biomarkers to predict the anticancer effects indicated drugs is considered a promising strategy for development precision medicine. DNA endonuclease MUS81 plays pivotal role in various biological processes during malignant diseases, mainly damage repair and replication fork stability. Our previous study reported that was highly expressed linked tumor metastasis gastric cancer; however, its therapeutic value has not been fully elucidated.Bioinformatics analysis used...
Immune response gene 1 (IRG1) is highly expressed in mitochondria of macrophages a pro-inflammatory state. IRG1 and its metabolites play important roles infection, immune-related diseases tumor progression by exerting resistance pathogens, attenuating inflammation producing antioxidant substances through various pathways mechanisms. deficiency aggravates liver injury. Efferocytosis vital mechanism for preventing the inflammatory tissue damage. However, how IRG1/itaconate regulates...
In the present study capacity of Radix Paeoniae Rubra aqueous extract (RPRAE) as an antioxidant to protect against carbon tetrachloride (CCl(4))-induced oxidative stress and hepatotoxicity in Wistar rats was investigated. Six groups were used. (100 or 200 300 mg/kg bw) bifendate given daily by gavage animals on 28 consecutive days elucidate protective effects CCl(4)-induced hepatotoxicity. The 20% CCl(4)/olive oil gastric tube twice a week (on third seventh each week). normal control group...
Wee1 is an oncogenic nuclear kinase, which can regulate the cell cycle as a crucial G2M checkpoint. Overexpression of be observed in various cancer types, may lead to poor prognosis, but potential therapeutic value colorectal has not been fully studied. In present study, role colonic was investigated. inhibition by small interfering RNA demonstrated significantly restrain proliferation and sensitize p53 mutant lines HT29 SW480 effect treatment with ionizing radiation. The anticancer...
Abstract Background The links between the p53/MDM2 pathway and expression of pro-oncogenic immune inhibitory receptors in tumor cells are undefined. In this report, we evaluate whether there is p53 and/or MDM2 dependence two key receptors, CD276 PD-L1. Methods Proximity ligation assays were used to quantify protein-protein interactions situ response Nutlin-3. A panel p53-null melanoma was created using CRISPR-Cas9 guide RNA mediated genetic ablation. Flow cytometric analyses assess impact...
4-Octyl itaconate (OI) is a novel anti-inflammatory metabolite that exerts protective effects in many various disease models. However, its function autoimmune hepatitis- (AIH-) associated hepatic injury has not been investigated. In this study, we successfully used concanavalin A (Con A) to establish an AIH-associated liver model. Furthermore, investigated the effect of OI Con A-induced and found mitigated histopathological damage. administration reduced serum levels alanine transaminase...
MUS81 is a critical endonuclease involved in heterodimer formation with Eme1/Mms4 and an important DNA damage repair regulatory molecule. Our previous study suggested that was overexpressed its high expression positively correlated gastric cancer metastasis. However, the therapeutic potential of targeting requires further exploration. Therefore, this study, Cancer Genome Atlas (TCGA) data were analyzed showed key regulator cell cycle distribution cancer. In vitro vivo , knockdown...