A5101680273- Saffron Plant Research Studies
- GABA and Rice Research
- Food Quality and Safety Studies
- Traditional Chinese Medicine Analysis
- Industrial Gas Emission Control
- COVID-19 and healthcare impacts
- COVID-19 Clinical Research Studies
- Rice Cultivation and Yield Improvement
- HER2/EGFR in Cancer Research
- Immune Cell Function and Interaction
- Ethnobotanical and Medicinal Plants Studies
- Bioactive Natural Diterpenoids Research
- Drug-Induced Hepatotoxicity and Protection
- Heme Oxygenase-1 and Carbon Monoxide
- Catalytic Processes in Materials Science
- Neurological Disease Mechanisms and Treatments
- Phytochemical and Pharmacological Studies
- Plant Gene Expression Analysis
- Microbial metabolism and enzyme function
- Stoma care and complications
- Free Radicals and Antioxidants
- Medicinal Plants and Bioactive Compounds
- Microbial Community Ecology and Physiology
- Macrophage Migration Inhibitory Factor
- Anorectal Disease Treatments and Outcomes
Sichuan University
2010-2024
Huazhong University of Science and Technology
2015-2023
Dalian Medical University
2016-2023
The Affiliated Yongchuan Hospital of Chongqing Medical University
2023
Chongqing Medical University
2023
Union Hospital
2023
Northwest A&F University
2023
Juntendo University
2022
Ministry of Agriculture and Rural Affairs
2021
Mianyang Central Hospital
2021
Although PARP inhibitor (PARPi) has been proven to be a promising anticancer drug in cancer patients harboring BRCA1/2 mutation, it provides limited clinical benefit colorectal with low prevalence of mutations. In our study, we found PARPi talazoparib significantly induced cellular senescence via inhibiting p53 ubiquitination and activating p21. Furthermore, CDK4/6i palbociclib amplified this therapy-induced (TIS) vitro vivo. Mechanistically, combination senescence-associated secretory...
Acrylamide, a well-documented neurotoxicant, is commonly found as byproduct of the Maillard reaction in carbohydrate-rich foods. Numerous studies have indicated that acrylamide-induced apoptosis accompanied by mitochondrial dysfunction contributes to its neurotoxicity. However, mechanisms how acrylamide causes impairment not well understood. In this study, we observed destroyed redox balance, accumulated reactive oxygen species (ROS), damaged structures, and activated astrocytes following...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccine-induced adaptive responses have been well investigated. However, the effects of sex, age, and ethnic background on immune elicited by vaccine remain unclear. Here, we performed comprehensive analyses SARS-CoV-2 vaccine. Vaccine-induced antibody T cell declined over time but persisted after 3 months, switched memory B cells were even increased. Spike-specific CD4+ CD8+ decreased against B.1.351 variant, not B.1.1.7....
Abstract Chronic exposures to arsenic had been associated with metabolism diseases. Peroxisome proliferator-activated receptor gamma (PPARγ) was found in the liver, regulated metabolism. Here, we that expression of PPARγ decreased, generation reactive oxygen species (ROS) and autophagy were increased after treatment As 2 O 3 offsprings’ livers. Taurine (Tau), a sulfur-containing β–amino acid could reverse -inhibited PPARγ. Tau also inhibit ROS autophagy. We caused autophagic cell death...
The main purposes of this study were to screen the antioxidant activities various fractions Hemerocallis citrina Baroni and test their hepatoprotective effects in vitro. Antioxidant assays (2,2‐diphenyl‐1‐picrylhydrazyl (DPPH), 2,2 ′ ‐azino‐bis(3‐ethylbenzothiazoline‐6‐sulfonic acid) (ABTS), reducing power experiments) tert‐butyl hydroperoxide‐ (t‐BHP‐) induced BRL‐3A oxidative damage experiments performed H. ethyl acetate fraction (HCEA) was determined have strong activity because its high...
Charcot–Marie–Tooth disease (CMT), also known as hereditary motor and sensory neuropathy, is the most common inherited peripheral nerve disorder. Missense mutations, such K141N, in small heat shock protein HSPB8 are to cause distal neuropathy 2A (dHMN2A) or Charcot-Marie-Tooth type 2L (CMT2L). However, of critical clinical significance, very few specific therapies for this exist. In present study, we investigated impact mutant K141N on mitochondrial distribution function a cellular model...
Antioxidant and hepatoprotective activities in vitro of saffron petals were examined this study for better utilizing (Crocus sativus L.) biowaste. Using the DPPH ABTS radical scavenging method, we compared antioxidant activity content total flavonoid extracts from (TFESP), stamens (TFESS), both (TFEMS). The results showed that capacity TFESP higher than those TFESS TFEMS. Then, was determined, silymarin used as a positive control. main components analysed by ultrahigh performance liquid...
Background: Doxorubicin (DOX) has been widely used in cancer treatment. However, DOX can cause a range of significant side effects, which hepatotoxicity is common one, and therefore limits its clinical use. Pterostilbene (PTS) shown to exhibit anti-oxidant anti-inflammatory effects the treatment liver diseases but whether PTS could protect against DOX-treated mice unknown. Methods: In our study, we use C57/BL6J HepG2 cell line. We divided 4 groups: control, treatment, + group. Liver...
Background: Humans with hypertensive heart disease are more likely to experience failure, arrhythmia, myocardial infarction, and sudden death, it is crucial treat this condition. Fucoidan (FO) a natural substance derived from marine algae that has antioxidant immunomodulatory activities. FO also been shown regulate apoptosis. However, whether can protect against cardiac hypertrophy unknown. Methods: We investigated the effect of in hypertrophic models vivo vitro. C57BL/6 mice were given an...
Arsenic exposure is related to insulin resistance (IR). However, the underlying mechanism still uncertain. NOD-like receptors containing pyrin domain 3 (NLRP3) inflammasome a key driving factor of IR. We found that NaAsO2 caused hepatic IR, activated NLRP3 inflammasome, and inhibited glycolysis pathway in vivo. also tricarboxylic acid cycle (TCA cycle) was inhibited, content lactate upregulated with treatment arsenic. Consistent these findings, we were involved development IR L-02 cells....
Lung cancer is the most common malignancy worldwide. With continuous spread of coronavirus disease 2019 (COVID-19) globally, it great significance to explore impact this on clinical characteristics lung cancer. Thus, we aimed investigate whether COVID-19 pandemic had any influence and diagnosis patients with We collected demographic data who were newly diagnosed at our hospital between February July 2020. Overall, 387 divided into two groups for analysis: epidemic group (from 2020)...
1-Methyl-4-phenylpyridinium ion (MPP(+)), an active metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, induces cell death and inhibition proliferation in various cells. However, the mechanism whereby MPP(+) inhibits is still unclear. In this study, we found that suppressed with accumulation G(1) phase without inducing p53-deficient MG63 osteosarcoma induced hypophosphorylation retinoblastoma protein rapidly down-regulated but not mRNA levels cyclin D1 The down-regulation was by a...
Soybeans can simultaneously form tripartite symbiotic associations with arbuscular mycorrhizal fungi (AMF) and diazotrophs. However, no studies have explored whether soybean genotypes differing in their maturity groups (MGs) may implications for the recruitment of rhizosphere soil AMF We investigated diversity community compositions diazotrophs three (MG) using high-throughput sequencing. The MGs were MG1.4, MG2.2, MG3.8, representing early, standard, late maturity, respectively, study...
<title>Abstract</title> <italic>Euphorbia hirta</italic> has anti-inflammatory effects in traditional medicine, but its mechanism not been explored at the cellular and molecular levels. To this end, main active components of 65% 95% ethanol extracts were first identified by UPLC-Q-TOF/MS. The potential targets signaling pathway through network pharmacology, followed subsequent experimental validation using lipopolysaccharide (LPS)-induced inflammation model RAW264.7 cells. results showed...
Objective: To study the active ingredients and mechanism of action "Herba Salviae Chinensis-Fructus Akebiae" drug pair in treatment non-small cell lung cancer (NSCLC) by using network pharmacology to provide theoretical basis for clinical application. Methods: The TCMSP (Traditional Chinese Medicine Systematic Pharmacology Database Analysis Platform) was used obtain targets Akebiae", results were analyzed Genecard (https://genecard, org/) database, Online Mendelian Inheritance Network (OMI),...