A5044330762- Climate variability and models
- Tropical and Extratropical Cyclones Research
- Meteorological Phenomena and Simulations
- Ocean Waves and Remote Sensing
- Oceanographic and Atmospheric Processes
- Gastrointestinal Tumor Research and Treatment
- COVID-19 epidemiological studies
- Coastal and Marine Dynamics
- Hydrology and Drought Analysis
- Gastric Cancer Management and Outcomes
- Inflammasome and immune disorders
- Gastrointestinal disorders and treatments
- Atmospheric and Environmental Gas Dynamics
- Climate Change and Health Impacts
- Immune cells in cancer
- Colorectal Cancer Surgical Treatments
- Climate change impacts on agriculture
- Atmospheric aerosols and clouds
- Influenza Virus Research Studies
- Flood Risk Assessment and Management
- Atmospheric chemistry and aerosols
- Wind and Air Flow Studies
- Arctic and Antarctic ice dynamics
- SARS-CoV-2 and COVID-19 Research
- Atmospheric Ozone and Climate
Princeton University
2019-2025
First Affiliated Hospital of Kunming Medical University
2023-2025
Kunming Medical University
2023-2025
Qingdao University
2025
Affiliated Hospital of Qingdao University
2025
Union Hospital
2019-2024
Huazhong University of Science and Technology
2019-2024
Ocean University of China
2024
The First Affiliated Hospital, Sun Yat-sen University
2024
Zhongshan Hospital
2024
Significance Nonpharmaceutical interventions (NPIs), such as social distancing, reduce not only COVID-19 cases but also other circulating infections influenza and RSV. The susceptible population for these will increase while NPIs are in place. Using models fit to historic of RSV influenza, we project large future outbreaks both diseases may occur following a period extended NPIs. These outbreaks, which reach peak numbers the winter, could burden healthcare systems.
Preliminary evidence suggests that climate may modulate the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Yet it remains unclear whether seasonal and geographic variations in can substantially alter pandemic trajectory, given high susceptibility is a core driver. Here, we use climate-dependent epidemic model to simulate SARS-CoV-2 by probing different scenarios based on known biology. We find although weather be important for endemic infections, during stage...
Abstract. Towards the end of June 2021, temperature records were broken by several degrees Celsius in cities Pacific Northwest areas US and Canada, leading to spikes sudden deaths sharp increases emergency calls hospital visits for heat-related illnesses. Here we present a multi-model, multi-method attribution analysis investigate extent which human-induced climate change has influenced probability intensity extreme heat waves this region. Based on observations, modelling classical...
Abstract East African precipitation is characterized by a dry annual mean climatology compared to other deep tropical land areas and bimodal cycle with the major rainy season during March–May (MAM; often called “long rains”) second October–December (OND; “short rains”). To explore these distinctive features, ERA-Interim data are used analyze associated cycles of atmospheric convective stability, circulation, moisture budget. The atmosphere over Africa found be convectively stable in general...
Abstract Decadal variability of the East African precipitation during season March–May (long rains) is examined and performance a series models in simulating observed features assessed. Observational results show that drying trend long rains associated with decadal natural sea surface temperature (SST) variations over Pacific Ocean. Empirical orthogonal function (EOF), linear regression, composite analyses all spatial pattern SST field to be La Niña like. The SST-forced International...
Drugs, viruses, and chemical poisons stimulating live in a short period of time can cause acute liver injury (ALI). ALI further develop into serious diseases such as cirrhosis cancer. Therefore, how to effectively prevent treat has become the focus research. Numerous studies have reported Maresin1 (MaR1) anti-inflammatory effect protective functions on organs. In present study, we used d-galactosamine/lipopolysaccharide (D-GalN/LPS) establish an model, explored mechanism cells death caused...
Abstract. Towards the end of June 2021, temperature records were broken by several degrees Celsius in cities Pacific northwest areas U.S. and Canada, leading to spikes sudden deaths, sharp increases hospital visits for heat-related illnesses emergency calls. Here we present a multi-model, multi-method attribution analysis investigate what extent human-induced climate change has influenced probability intensity extreme heatwaves this region. Based on observations modeling, occurrence heatwave...
Abstract As a direct consequence of extreme monsoon rainfall throughout the summer 2022 season Pakistan experienced worst flooding in its history. We employ probabilistic event attribution methodology as well detailed assessment dynamics to understand role climate change this event. Many available state-of-the-art models struggle simulate these characteristics. Those that pass our evaluation test generally show much smaller likelihood and intensity than trend we found observations. This...
Cuproptosis, a novel copper-induced cell death pathway, is linked to mitochondrial respiration and mediated by protein lipoylation. The discovery of cuproptosis unfolds new areas investigation, particularly in cancers. present study aimed explore the role colorectal cancer progression. genetic alterations colon were evaluated using database. MTT assays, colony formation, flow cytometry used examine effect elesclomol-Cu 4-Octyl itaconate (4-OI) on oxaliplatin-resistant viability. anti-tumor...
From October 2020 to early 2023, Eastern Africa experienced five consecutive failed rainy seasons, resulting in the worst drought 40 years. This led harvest failures, livestock losses, water scarcity, and conflicts, leaving approximately 4.35 million people need of humanitarian aid. To understand role human-induced climate change drought, we analysed rainfall trends combined effect deficit with high temperatures Southern Horn covering parts southern Ethiopia, Somalia, eastern Kenya. We...
Abstract A key question for infectious disease dynamics is the impact of climate on future burden. Here, we evaluate drivers respiratory syncytial virus (RSV), an important determinant in young children. We combine a dataset county-level observations from US with state-level Mexico, spanning much global range climatological conditions. Using combination nonlinear epidemic models statistical techniques, find consistent patterns at continental scale explaining latitudinal differences and...
Abstract The most recent generation of climate models (the 6th Phase the Coupled Model Intercomparison Project) yields estimates effective sensitivity (ECS) that are much higher than past generations due to a stronger amplification from cloud feedback. If plausible, these require substantially larger greenhouse gas reductions meet global warming targets. We show with more positive feedback also have cooling effect aerosol‐cloud interactions. These two effects offset each other during...
Abstract Tropical cyclone rapid intensification events often cause destructive hurricane landfalls because they are associated with the strongest storms and forecasts highest errors. Multi-decade observational datasets of tropical behavior have recently enabled documentation upward trends in several basins. However, a robust anthropogenic signal global physical drivers yet to be identified. To address these knowledge gaps, here we compare observed environmental parameters simulated natural...
Abstract Oxaliplatin is widely used in chemotherapy for colorectal cancer (CRC), but its sensitivity has become a major obstacle to limiting efficacy. Many literatures reported that Nrf2 activation promoted tumor chemoresistance. In this study, we explored the role and mechanism of inhibition oxaliplatin-based chemosensitivity CRC. vitro experiments, applied 4-octyl itaconate (4-OI) activate Nrf2, lentivirus knock down CRC cell lines. By measuring viability, colony formation, apoptosis,...
Abstract Since 2019, Central South America (CSA) has been reeling under drought conditions, with the last 4 months of 2022 receiving only 44% average total precipitation. Simultaneously to drought, a series record-breaking heat waves affected region. The rainfall deficit during October–November-December (OND) is highly correlated Niño3.4 index, indicating that OND partly driven by La Niña, as observed in previous droughts this To identify whether human-induced climate change was also driver...
Abstract In March 2022, large parts over the north Indian plains including breadbasket region, and southern Pakistan began experiencing prolonged heat, which continued into May. The event was exacerbated due to prevailing dry conditions in resulting devastating consequences for public health agriculture. Using attribution methods, we analyse role of human-induced climate change altering chances such an event. To capture extent impacts, choose March–April average daily maximum temperature...
Abstract. Global-mean surface temperature rapidly increased 0.29 ± 0.04 K from 2022 to 2023. Such a large interannual global warming spike is not unprecedented in the observational record, with previous instance occurring 1976–1977. However, why such spikes occur unknown, and rapid of 2023 has led concerns that it could have been externally driven. Here we show climate models are subject only internal variability can generate spikes, but they an uncommon occurrence (p = 1.6 % 0.1 %). when...
Abstract East Africa has two rainy seasons: the long rains [March–May (MAM)] and short [October–December (OND)]. Most CMIP3/5 coupled models overestimate while underestimating rains. In this study, African rainfall bias is investigated by comparing historical simulations from CMIP5 to corresponding SST-forced AMIP simulations. Much of investigation focused on MRI-CGCM3 model, which successfully reproduces observed annual cycle in experiment but its simulation a similar stronger as multimodel...
Abstract Explosivevolcanic eruptions have large climate impacts and can serve as observable tests of the climatic response to radiative forcing. Using a high‐resolution model, we contrast responses Pinatubo, with symmetric forcing, those Santa Maria Agung, which had meridionally asymmetric Although Pinatubo larger global‐mean forcing strongly shifts latitude tropical rainfall features, leading local precipitation/tropical cyclone changes. For example, North Atlantic activity over is...