A5110014906- COVID-19 epidemiological studies
- Virology and Viral Diseases
- SARS-CoV-2 and COVID-19 Research
- Vaccine Coverage and Hesitancy
- Evolution and Genetic Dynamics
- Viral Infections and Outbreaks Research
- Influenza Virus Research Studies
- Zoonotic diseases and public health
- Plant and animal studies
- Viral Infections and Vectors
- Animal Disease Management and Epidemiology
- Mosquito-borne diseases and control
- Ecology and Vegetation Dynamics Studies
- Mathematical and Theoretical Epidemiology and Ecology Models
- Malaria Research and Control
- Immune responses and vaccinations
- Data-Driven Disease Surveillance
- COVID-19 Pandemic Impacts
- Gut microbiota and health
- Viral Infections and Immunology Research
- Respiratory viral infections research
- Human Mobility and Location-Based Analysis
- COVID-19 Clinical Research Studies
- Evolutionary Game Theory and Cooperation
- Viral gastroenteritis research and epidemiology
Princeton University
2016-2025
Princeton Public Schools
2020-2025
Institute for Advanced Study
2022
Woodrow Wilson International Center for Scholars
2013-2021
University of Cambridge
2021
National Institutes of Health
2014-2020
Fogarty International Center
2012-2020
Brigham and Women's Hospital
2020
Maine Medical Center Research Institute
2020
Wellcome Trust
2020
Significance Nonpharmaceutical interventions (NPIs), such as social distancing, reduce not only COVID-19 cases but also other circulating infections influenza and RSV. The susceptible population for these will increase while NPIs are in place. Using models fit to historic of RSV influenza, we project large future outbreaks both diseases may occur following a period extended NPIs. These outbreaks, which reach peak numbers the winter, could burden healthcare systems.
As of 24 April 2020, the SARS-CoV-2 epidemic has resulted in over 830,000 confirmed infections United States1. The incidence COVID-19, disease associated with this new coronavirus, continues to rise. threatens overwhelm healthcare systems, and identifying those regions where burden is likely be high relative rest country critical for enabling prudent effective distribution emergency medical care public health resources. Globally, risk severe outcomes COVID-19 consistently been observed...
As the coronavirus disease 2019 (COVID-19) epidemic worsens, understanding effectiveness of public messaging and large-scale social distancing interventions is critical. The research health response communities can should use population mobility data collected by private companies, with appropriate legal, organizational, computational safeguards in place. When aggregated, these help refine providing near real-time information about changes patterns human movement.
Extra dividends from measles vaccine Vaccination against has many benefits, not only lifelong protection this potentially serious virus. Mina et al. analyzed data collected since mass vaccination began in high-income countries when was common. Measles is associated with less mortality other childhood infections. known to cause transient immunosuppression, but close inspection of the suggests that it disables immune memory for 2 3 years. thus does more than safeguard children measles; also...
Influenza epidemics vary in intensity from year to year, driven by climatic conditions and viral antigenic evolution. However, important spatial variation remains unexplained. Here we show predictable differences influenza incidence among cities, population size structure. Weekly data 603 cities the United States reveal that smaller are focused on shorter periods of season, whereas larger is more diffuse. Base transmission potential estimated city-level positively correlated with...
Preliminary evidence suggests that climate may modulate the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Yet it remains unclear whether seasonal and geographic variations in can substantially alter pandemic trajectory, given high susceptibility is a core driver. Here, we use climate-dependent epidemic model to simulate SARS-CoV-2 by probing different scenarios based on known biology. We find although weather be important for endemic infections, during stage...
Summary Integral projection models ( IPM s) use information on how an individual's state influences its vital rates – survival, growth and reproduction to make population projections. s are constructed from regression predicting variables e.g . size or age) covariates environment). By combining regressions of rates, provides mechanistic insight into emergent ecological patterns such as dynamics, species geographic distributions life‐history strategies. Here, we review important resources for...
Summary Schedules of survival, growth and reproduction are key life‐history traits. Data on how these traits vary among species populations fundamental to our understanding the ecological conditions that have shaped plant evolution. Because demographic schedules determine population or decline, such data help us understand different biomes shape ecology, communities respond global change develop successful management tools for endangered invasive species. Matrix models summarize life cycle...
The future trajectory of the coronavirus disease 2019 (COVID-19) pandemic hinges on dynamics adaptive immunity against severe acute respiratory syndrome 2 (SARS-CoV-2); however, salient features immune response elicited by natural infection or vaccination are still uncertain. We use simple epidemiological models to explore estimates for magnitude and timing COVID-19 cases, given different assumptions regarding protective efficacy duration SARS-CoV-2, as well its interaction with vaccines...
A central conundrum in the study of infectious disease dynamics is to define landscape population immunity. The proportion individuals protected against a specific pathogen determines timing and scale outbreaks, pace evolution for infections that can evade prevailing humoral Serological surveys provide most direct measurement immunity many diseases, yet this methodology remains underexploited. To address gap, we propose World Serology Bank associated major methodological developments...
Given vaccine dose shortages and logistical challenges, various deployment strategies are being proposed to increase population immunity levels severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Two critical issues arise: How timing of delivery the second will affect infection dynamics how it prospects for evolution viral immune escape via a buildup partially individuals. Both hinge on robustness response elicited by single as compared with natural two-dose immunity. Building an...
In-person schooling has proved contentious and difficult to study throughout the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. Data from a massive online survey in United States indicate an increased risk of COVID-19-related outcomes among respondents living with child attending school person. School-based mitigation measures are associated significant reductions risk, particularly daily symptoms screens, teacher masking, closure extracurricular activities. A...
There is increasing interest in the plant microbiome as it relates to both health and agricultural sustainability. One key unanswered question whether we can select for a that robust after colonization of target hosts. We used successive passaging experiment address this by selecting upon tomato phyllosphere microbiome. Beginning with diverse microbial community generated from field-grown plants, inoculated replicate plants across 5 genotypes 4 45-d passages, sequencing at each passage....
The Ebola epidemic in West Africa has caused substantial morbidity and mortality. outbreak also disrupted health care services, including childhood vaccinations, creating a second public crisis. We project that after 6 to 18 months of disruptions, large connected cluster children unvaccinated for measles will accumulate across Guinea, Liberia, Sierra Leone. This pool susceptibility increases the expected size regional from 127,000 227,000 cases months, resulting 2000 16,000 additional deaths...
Significance For many infections, some infected individuals transmit to disproportionately more susceptibles than others, a phenomenon referred as “superspreading.” Understanding superspreading can facilitate devising individually targeted control measures, which may outperform population-level measures. Superspreading has been described for recent Ebola virus (EBOV) outbreak, but systematic characterizations of its spatiotemporal dynamics are still lacking. We introduce statistical...
We can exploit randomized controlled trials, compartmental models, and spillovers