A5041358763- Redox biology and oxidative stress
- Neuroscience and Neuropharmacology Research
- Endoplasmic Reticulum Stress and Disease
- RNA modifications and cancer
- Biochemical effects in animals
- Heat shock proteins research
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Parkinson's Disease Mechanisms and Treatments
- MicroRNA in disease regulation
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurotransmitter Receptor Influence on Behavior
- Genomics, phytochemicals, and oxidative stress
- Autophagy in Disease and Therapy
- Ferroptosis and cancer prognosis
- Neurological Disease Mechanisms and Treatments
- Circular RNAs in diseases
- Neuropeptides and Animal Physiology
- Nitric Oxide and Endothelin Effects
- Ginseng Biological Effects and Applications
- Cancer-related gene regulation
- Nerve injury and regeneration
- Identification and Quantification in Food
- Bioactive natural compounds
- Connexins and lens biology
Kunming University of Science and Technology
2016-2025
Capital Medical University
2011-2024
Center for Children
2024
Hebei University
2010-2024
Peking University Third Hospital
2024
Beijing Children’s Hospital
2024
Peking University
2024
Nanjing University of Chinese Medicine
2023
Huazhong University of Science and Technology
2014-2021
Union Hospital
2016-2021
Thioredoxin (Trx), a redox enzyme with conserved active site (Cys-32–Gly–Pro–Cys-35), is induced and secreted into circulation in response to inflammation. Studies here demonstrate that elevating Trx levels either by i.v. injection of recombinant or stimulating release Trx-transgenic mice dramatically blocks lipopolysaccharide (LPS)-stimulated neutrophil migration the murine air pouch chemotaxis model. Furthermore, we show leukocyte recruitment chemokines KC/GROα, RANTES (regulated upon...
Parkinson's disease (PD) is a progressive neurodegenerative disorder. Its molecular mechanism still unclear, and pharmacological treatments are unsatisfactory. Transient receptor potential vanilloid 4 (TRPV4) nonselective Ca2+ channel. It has recently emerged as critical risk factor in the pathophysiology of neuronal injuries cerebral diseases. Our previous study reported that TRPV4 contributed to endoplasmic reticulum (ER) stress MPP+-induced cell model PD. In present study, we detected...
MicroRNAs (miRNAs) play important roles in the progression of human cancer. Although previous reports have shown that miR-145-5p is down-regulated esophageal squamous cell carcinoma (ESCC), and mechanisms down-regulation ESCC are still largely unknown. Using microRNA microarray Gene Expression Omnibus (GEO) datasets, we confirmed was tissues. In vitro assays revealed ectopic expression repressed proliferation, migration, invasion epithelial to mesenchymal transition (EMT). also reduced...
Panax notoginseng, a traditional Chinese medicine, has been used for thousands of years to treat ischemic patients. More than 20 saponin components have isolated from P. notoginseng root and identified chemically. However, these different chemical roles. In this study we compared the neuroprotective mechanisms ginsenosides Rg1, Rb1, Rg1/Rb1, panax notoginsenoside (PNS) against injuries caused by cerebral ischemia–reperfusion (I/R). Our results show that all treatments significantly reduced...
Recent studies have shown that interferon-γ (IFN-γ)-induced galectin-9 expression in Kupffer cells plays an essential role modulatingthe microenvironment of hepatitis-associated hepatocellular carcinoma (HCC). However, whether or not IFN-γ induces HCC cells, its biological and regulatory mechanism development progression are poorly defined. Quantitative PCR western blotting analysis were used to detect EZH2 levels cell lines stimulated with IFN-γ. Bioinformatics luciferase reporter assay...
Solute carrier family 7 member 11 (SLC7A11), glutathione peroxidase 4 (GPX4), and apoptosis inducing factor mitochondria associated 2 (AIFM2) are the key regulators in ferroptosis. However, expression patterns prognostic roles of these genes pan-cancer still largely unclear. The SLC7A11, GPX4, AIFM2 relationships between levels immune infiltration were analyzed by using TIMER, gene profiling interactive analysis (GEPIA), Oncomine, Kaplan–Meier databases. Our results showed that both SLC7A11...
Abstract Parkinson’s disease (PD) is characterized by the formation of Lewy body in dopaminergic neurons substantia nigra pars compacta (SNpc). Alpha-synuclein (α-syn) a major component body. Autophagy eliminates damaged organelles and abnormal aggregated proteins. Thioredoxin-1 (Trx-1) redox regulating protein plays roles protecting against neurotoxicity induced 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). However, relationship between Trx-1 α-syn PD still unknown. In present study,...
Thioredoxin (TRX) has a role in variety of biological processes, including cytoprotection and the activation transcription factors. Nerve growth factor (NGF) is major survival sympathetic neurons promotes neurite outgrowth rat pheochromocytoma PC12 cells. In this study, we showed that NGF induces TRX expression at protein mRNA levels. activated gene through regulatory region positioned from -263 to -217 bp, containing cAMP-responsive element (CRE). Insertion mutation CRE abolished response...
MicroRNAs (miRNAs) play important roles in the progression of human cancer including esophageal squamous cell carcinoma (ESCC). Although previous reports showed that miR-125b-5p was down-regulated ESCC, and mechanisms loss function ESCC were still unknown. Using microRNA microarray GEO datasets, we found confirmed tissues. In-vitro assays ectopic expression repressed proliferation, migration invasion, induced senescence. We also reduced expressions cycle regulatory genes CCNA2, CCND1 CCNE1,...
Exposure to excessive light induces retinal photoreceptor cell damage, leading development and progression of various diseases. We tested the effect geranylgeranylacetone (GGA), an acyclic polyisoprenoid, on light-induced damage in mice. Oral treatment with GGA (1.0 mg/d) for 5 d induced thioredoxin (Trx) heat shock protein 72 (Hsp72) predominantly pigment epithelium (RPE). After white exposure (8000 lux 2 h), percentage terminal deoxynucleotidyl transferase-mediated biotinylated UTP nick...
Esophageal squamous cell carcinoma (ESCC) is one of the most frequent malignant tumors, and mechanisms underlying anti-ferroptosis esophageal cancer cells are still largely unclear. This study aims to explore roles amplified protein kinase C iota (PKCiota) in ferroptosis ESCC cells. Cell viability, colony formation, MDA assay, Western blotting, co-IP, PLA, RNA-seq technologies used reveal PKCiota-induced resistance ferroptosis. We showed here that PKCiota was overexpressed decreased during...
The phosphoinositide 3-kinase/Akt pathway activation commonly occurs in various types of human cancer and has an important role chemoresistance. Combination traditional chemotherapy drugs molecular-targeted agents is a promising strategy for therapy, which shown enhanced cytotoxicity lower drug resistance. present study found that the Akt inhibitor, MK-2206, can increase effect cisplatin gastric cell line AGS, higher phosphorylation, but exhibited poor combination MKN-45 MGC-803 cells, have...
Abstract Oesophageal squamous cell carcinoma (ESCC) is a common and aggressive malignancy. Although many molecular alterations have been observed in ESCC, the mechanisms underlying development progression of this disease remain unclear. In present study, miR-1224-5p was identified to be downregulated ESCC tissues compared normal tissues, its low expression correlated with shorter survival time patients. vitro experiments showed that inhibited proliferation, colony formation, migration...