A5101630374- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Natural product bioactivities and synthesis
- Phytochemistry and Bioactive Compounds
- Phytochemistry and Biological Activities
- Phytochemical compounds biological activities
- Advanced biosensing and bioanalysis techniques
- Biological Activity of Diterpenoids and Biflavonoids
- Alkaloids: synthesis and pharmacology
- DNA and Nucleic Acid Chemistry
- RNA modifications and cancer
- Petri Nets in System Modeling
- Natural Compounds in Disease Treatment
- Traditional Chinese Medicine Analysis
- Metalloenzymes and iron-sulfur proteins
- Ginseng Biological Effects and Applications
- Marine Sponges and Natural Products
- Advanced Control Systems Optimization
- RNA and protein synthesis mechanisms
- Magnolia and Illicium research
- Process Optimization and Integration
- Scheduling and Optimization Algorithms
- Metal-Organic Frameworks: Synthesis and Applications
- Oxidative Organic Chemistry Reactions
- Traditional and Medicinal Uses of Annonaceae
Biogas Institute of Ministry of Agriculture
2021-2025
Ministry of Agriculture and Rural Affairs
2021-2025
Macau University of Science and Technology
2016-2025
Kunming University of Science and Technology
2018-2025
Shanxi Academy of Medical Sciences
2023-2025
Shanxi Medical University
2025
Nankai University
2024-2025
Osaka University
2024
University of Science and Technology Beijing
2024
Northeastern University
2022
We report here the first application of Group 9 metal complexes (i.e.iridium(III) and rhodium(III)) as inhibitors amyloid fibrillogenesis luminescent probes for Aβ1–40peptide. These contained aromatic co-ligands to interact with hydrophobic residues around N-terminal domain Aβ1–40peptide, well solvato allow coordinative bond formation histidine residues. demonstrate that these could inhibit Aβ1–40peptide aggregation in vitro, potency superior previous metal-based reported. Furthermore, we...
This work studies the scheduling problem of a single-arm multicluster tool with linear topology and process-bound bottleneck individual tool. The objective is to find one-wafer cyclic schedule such that lower bound cycle time reached by optimally configuring spaces in buffering modules link cluster tools. A Petri net (PN) model developed describe dynamic behavior system extending resource-oriented PNs can be parameterized robots' waiting time. Based on this model, conditions are presented...
Stopping aggregation: Carbazole-based cyanine fluorophores bind selectively to the Aβ(1–40) peptide and its aggregates which are responsible for causing Alzheimer's disease. One of these fluorophores, SLOH, exerts a strong inhibitory effect on fibrillogenesis (see scheme) can pass through blood-brain barrier making it potential therapeutic agent
In some refineries, storage tanks are located at two different sites, one for low-fusion-point crude oil and the other high one. Two pipelines used to transport types. Due constraints resulting from high-fusion-point transportation, it is challenging schedule such a system. This work studies scheduling problem control-theoretic perspective. It proposes use hybrid Petri net method model then finds schedulability conditions by analysing dynamic behaviour of model. Next, an efficient minimize...
Currently, infections caused by drug-resistant bacteria have become a new challenge in anti-infective treatment, seriously endangering public health. In our continuous effort to develop antimicrobials, series of novel honokiol/magnolol amphiphiles were prepared mimicking the chemical structures and antibacterial properties cationic antimicrobial peptides. Among them, compound 5i showed excellent activity against Gram-positive clinical MRSA isolates (minimum inhibitory concentrations (MICs) =...
A novel series of thirty coumarin derivatives (4a ∼ r, 5a l) constituted by and cinnamic acid/benzoic acid through oxime linkage were synthesized evaluated for their potential anti-tyrosinase activity. Among them, compound 5l exhibited outstanding activity with IC50 3.04 ± 0.01 μM compared to 14.13 0.80 kojic acid. Kinetic study revealed be a reversible uncompetitive tyrosinase inhibitor. 3D fluorescence CD spectra results showed treatment lead the conformational changes tyrosinase....
Two novel iridoid–phenylethanoid glycoside heterodimers, verbenalinoside A (1) and B (2), along with two known precursors, verbenalin (3) verbascoside (4) were isolated from the dry aerial parts of Verbena officinalis. Verbenalinoside possesses a new 5/6/6/6 core fused by double bond iridoid phenolic hydroxyl groups phenylethanoid unit. (2) is conjugate an ether bond. The structures these compounds elucidated through comprehensive analysis spectroscopic data, supported electronic circular...
The first application of crystal violet as a selective fluorescent switch-on probe for i-motif DNA has been reported. This interaction exploited to develop label-free DNA-based "OR" logic gate potassium and hydrogen ions.
Ultrasensitive detection of heavy metal ions through electrochemical methods is a longstanding research topic. One the most compelling subjects preparation modified electrodes with high specific surface area as well fast response characteristics. In this study, novel bismuth oxide surface-decorated nanoporous (Bi2O3@NPBi) was prepared typical dealloying method, where bicontinuous ligament–channel structure greatly improved electrically active and electron conduction. The Bi2O3@NPBi-modified...
Single-molecule junctions, integrating individual molecules as active components between electrodes, serve fundamental building blocks for advanced electronic and sensing technologies. The application of ionic liquids in single-molecule junctions represents a cutting-edge rapidly evolving field research at the intersection nanoscience, materials chemistry, electronics. This review explores recent advances where function electrolytes, dielectric layers, structural elements within reshaping...
With a combinatorial nature and hybrid characteristics, it is very challenging to schedule crude oil operations in refinery and, up now, there no software tool for practical use this field. To solve problem, based on the two-level architecture our previous work, cases where mixing required, paper investigates refining scheduling problem at upper level. Based schedulability conditions, three-stage approach proposed. First, linear programming model developed maximize productivity. Second,...
Reactions of La(NO3)3·6H2O with the polar, tritopic quaternized carboxylate ligands N-carboxymethyl-3,5-dicarboxylpyridinium bromide (H3CmdcpBr) and N-(4-carboxybenzyl)-3,5-dicarboxylpyridinium (H3CbdcpBr) afford two water-stable metal–organic frameworks (MOFs) {[La4(Cmdcp)6(H2O)9]}n (1, 3D) {[La2(Cbdcp)3(H2O)10]}n (2, 2D). MOFs 1 2 absorb carboxyfluorescein (FAM)-tagged probe DNA (P-DNA) quench fluorescence FAM via a photoinduced electron transfer (PET) process. The nonemissive P-DNA@MOF...
Abstract Primary bile acids (BAs), products of cholesterol metabolism and clearance, are synthesized in the liver released into intestine to facilitate digestion absorption lipids. BAs further converted by gut commensal bacteria secondary colonic disorder is closely linked cholestatic diseases via regulating immune response. However, effect underlying mechanism these host-microorganism biliary metabolites on T lymphocyte remain unclear. In current study, we a sulfated product lithocholic...
COVID-19 is still a global public health concern, and the SARS-CoV-2 mutations require more effective antiviral agents. In this study, entry activity of thirty-one flavonoids was systematically evaluated by pseudovirus model. Twenty-four exhibited with IC50 values ranging from 10.27 to 172.63 µM SI 2.33 48.69. The structure-activity relationship these as inhibitors comprehensively summarized. A subsequent biolayer interferometry assay indicated that bind viral spike RBD block interaction...