A5044897313- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Cancer, Lipids, and Metabolism
- Immune cells in cancer
- Biosensors and Analytical Detection
- Cancer-related molecular mechanisms research
- Advanced Data Processing Techniques
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- ATP Synthase and ATPases Research
- Retinal and Optic Conditions
- COVID-19 Clinical Research Studies
- Drug-Induced Ocular Toxicity
- Genetic and Kidney Cyst Diseases
- Liver Disease Diagnosis and Treatment
- Salmonella and Campylobacter epidemiology
- Medical Image Segmentation Techniques
- Reservoir Engineering and Simulation Methods
- Hydraulic Fracturing and Reservoir Analysis
- Child and Adolescent Psychosocial and Emotional Development
- Listeria monocytogenes in Food Safety
- Peroxisome Proliferator-Activated Receptors
- Mast cells and histamine
- NF-κB Signaling Pathways
Peking University
2015-2025
Peking University Third Hospital
2020-2025
McGovern Institute for Brain Research
2024-2025
Tsinghua University
2024-2025
Center for Life Sciences
2024-2025
King Center
2025
Macau University of Science and Technology
2021-2024
Affiliated Eye Hospital of Wenzhou Medical College
2024
Wenzhou Medical University
2024
Northeast Petroleum University
2024
Abstract The regulation of PD‐L1 is the key question, which largely determines outcome immune checkpoint inhibitors (ICIs) based therapy. However, besides transcription level, protein stability closely correlated with its function and has drawn increasing attention. In this study, EZH2 inhibition enhances expression stability, deubiquitinase ubiquitin‐specific peptidase 22 (USP22) identified as a mediator in process. transcriptionally upregulates USP22 expression, upregulated further...
EZH2 inhibitors (EZH2i), a class of small-molecule that target to exert anti-tumor functions, have just been approved by the US Food and Drug Administration (FDA) in treatment adults adolescents with locally advanced or metastatic epithelioid sarcoma. The application EZH2i several solid tumors is still different stages clinical trials needs be further validated. As key epigenetic regulator, besides its role controlling proliferation tumor cells, has implicated regulation various immune cells...
// Jiangbo Zhang 1, 2, * , Jin Cheng 3, Zhenzhen Zeng Yongfeng Wang 1 Xiaojun Li Qing Xie 4 Junqiao Jia Ying Yan Zhengyang Guo Jian Gao Mingjie Yao Xiangmei Chen Fengmin Lu Department of Microbiology & Infectious Disease Center, School Basic Medical Sciences, Peking University Health Science Beijing 100191, China 2 Sun Yat-sen Cancer State Key Laboratory Oncology in South China, Collaborative Innovation Center for Medicine, Guangzhou 510060, 3 Institute Sports Injuries, Third Hospital,...
Sensitivity has been a key issue for Enhancer of zeste homolog 2 (EZH2) inhibitors in cancer therapy. The EZH2 inhibitor EPZ-6438 was first approved by the US Food and Drug Administration (FDA) 2020. However, its inadequate anti-cancer activity solid tumors limits clinical application. In this study, we utilized multiple cell lines, which are less sensitive to GSK126, combining animal model data investigate underlying mechanism.IncuCyte S3 used explore difference responsiveness hematological...
Abstract Primary bile acids (BAs), products of cholesterol metabolism and clearance, are synthesized in the liver released into intestine to facilitate digestion absorption lipids. BAs further converted by gut commensal bacteria secondary colonic disorder is closely linked cholestatic diseases via regulating immune response. However, effect underlying mechanism these host-microorganism biliary metabolites on T lymphocyte remain unclear. In current study, we a sulfated product lithocholic...
Chloroquine (CQ) and hydroxychloroquine (HCQ) have been challenged in treating COVID-19 patients still under debate due to the uncertainty regarding effectiveness safety, there is lack of systematic study on toxicity these two drugs. To further uncover profile CQ HCQ different tissues, we evaluated cytotoxicity them eight cell lines adopted physiologically based pharmacokinetic models predict tissue risk, respectively. Retina, myocardium, lung, liver, kidney, vascular endothelium, intestinal...
Accurate segmentation of subcellular components is crucial for understanding cellular processes, but traditional methods struggle with noise and complex structures. Convolutional neural networks improve accuracy require large, time-consuming, biased manually annotated datasets. Here, we developed SynSeg, a pipeline that generates synthetic training data to train U-net model structure segmentation, eliminating the need manual annotation. SynSeg leverages datasets variations in intensity,...
The tubulin tail is a key element for microtubule (MT) functionality, but the functional redundancy of genes complicates genetic determination their physiological functions. Here, we removed C-terminal five alpha- and four beta-tubulin in C. elegans genome. Sensory cilia typically exhibit an axoneme that longitudinally differentiates into middle segment with doublet MTs distal singlet MTs. However, excision alpha-tubulin tail, not resulted ectopic formation segments. Molecular dynamics...
Abstract Ovarian cancer (OC) is the most aggressive and lethal gynecological associated with abnormal lipid metabolism. Enhancer of zeste homolog 2 (EZH2), catalytic subunit polycomb repressive complex 2, overexpressed in OC other various cancers. It functions as a tumor promoter through canonical H3K27me3 modification non-canonical ways, considered potential anticancer target. Although numerous EZH2 inhibitors have been developed tested clinical trials, therapeutic effect on solid tumors...
Aberrant upregulation or mutations of EZH2 frequently occur in human cancers. However, the clinical benefits inhibitors (EZH2i) remain unsatisfactory for majority solid tumors. Therefore, there is an urgent need to develop new strategies expand therapeutic EZH2i. Nanocarriers have gained increased attention due their advantages prolonged blood circulation, enhanced cellular uptake, and active targeting capabilities. This study aims address challenges EZH2i GSK126's limited efficacy severe...
Inhibitor of nuclear factor kappa-B kinase subunit beta (IKKβ) is one important kinases in inflammation to phosphorylate inhibitor (IκBα) and then activate (NF-κB). Inhibition IKKβ has been a therapeutic strategy for inflammatory autoimmune diseases. Here we report that constitutively activated healthy donors Ikkβ C46A (cysteine 46 mutated alanine) knock-in mice although they possess intensive IKKβ-IκBα-NF-κB signaling activation. These indicate activation probably plays homeostatic role...
Prediction of fluid production from hydraulically fractured wells is often difficult due to the incomplete understanding mechanism and limited availability data. In this paper, we propose a prediction model (MTL-Bi-LSTM-CNN) predict in all layers based on convolutional neural network (CNN), bidirectional long short-term memory (Bi-LSTM) multi-task learning (MTL). The integrates fracturing parameters with data various each well. It harnesses both forward backward bi-directional information...
Abstract Foodborne illnesses associated with foodborne pathogens Listeria monocytogenes and Staphylococcus aureus occur at high frequencies. In this study, species‐specific primers probes sets for the detection of L. S. were designed based on nucleotide sequences actin‐assembly inducing protein precursor ( actA ) clumping factor A clfA genes, respectively. We established a duplex RPA assay that is capable simultaneously detecting within 15 min. With plasmid standard, sensitivity double to...
Chemical investigation of medicinal plant Glycosmis lucida Wall. ex C. Huang leaves led to the production ten compounds (1-10), including two previously unreported geranylated sulfur-containing amides (1 and 2) eight known ones (3-10). Structural characterization was carried out using comprehensive spectroscopic methods NMR, MS CD. The inhibitory effects all isolates on Th17 differentiation were evaluated, which 1 6 significantly inhibited with IC50 values 0.36 1.30 μM, respectively, while...
Abstract Chloroquine (CQ) and hydroxychloroquine (HCQ) have been used in treating COVID-19 patients recently. However, both drugs some contradictions rare but severe side effects, such as hypoglycemia, retina cardiac toxicity. To further uncover the toxicity profile of CQ HCQ different tissues, we evaluated cytotoxicity them 8 cell lines, adopted physiologically-based pharmacokinetic models (PBPK) to predict tissue risk respectively. Retina, myocardium, lung, liver, kidney, vascular...