A5100322938- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Ubiquitin and proteasome pathways
- Histone Deacetylase Inhibitors Research
- Gut microbiota and health
- Cancer-related Molecular Pathways
- Ferroptosis and cancer prognosis
- RNA Research and Splicing
- Cancer, Hypoxia, and Metabolism
- Protein Degradation and Inhibitors
- Microtubule and mitosis dynamics
- Peptidase Inhibition and Analysis
- Immune Cell Function and Interaction
- MicroRNA in disease regulation
- Lung Cancer Treatments and Mutations
- DNA Repair Mechanisms
- Estrogen and related hormone effects
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cytokine Signaling Pathways and Interactions
- Glycosylation and Glycoproteins Research
- RNA Interference and Gene Delivery
- Occupational and environmental lung diseases
- Cancer Mechanisms and Therapy
Shanghai Jiao Tong University
2008-2025
Shandong University
2016-2025
Peking University
2016-2025
Peking University Cancer Hospital
2019-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2025
Third Hospital of Changsha
2025
University of Shanghai for Science and Technology
2012-2025
Capital Medical University
2016-2025
Tianjin Medical University
2016-2025
Nankai University
2022-2025
SOX genes encode a family of high-mobility group transcription factors that play critical roles in organogenesis. The functional specificity different proteins and the tissue particular factor are largely determined by differential partnership with other regulators, many which have not yet been discovered. Virtually all members found to be deregulated wide variety tumors. However, little is known about cellular molecular behaviors involved oncogenic potential proteins. Using cell culture...
Essential for embryonic development, the polycomb group protein enhancer of zeste homolog 2 (EZH2) is overexpressed in breast and prostate cancers implicated growth aggression tumors. The tumorigenic mechanism underlying EZH2 overexpression largely unknown. It believed that exerts its biological activity as a transcription repressor. However, we report here functions gene transcriptional activation cancer cells. We show transactivates genes are commonly targeted by estrogen Wnt signaling...
COVID-19 is a highly infectious respiratory disease. No therapeutics have yet been proven effective for treating severe COVID-19.To determine whether human umbilical cord mesenchymal stem cell infusion may be and safe the treatment of COVID-19.Patients with were randomly divided into 2 groups: standard group plus hUC-MSC group. The incidence progression from to critical illness, 28-day mortality, clinical symptom improvement, time hematologic indicators including C-reactive protein,...
Recent studies have demonstrated that there are significant changes in the gut microbiota (GM) of humans with depression and animal models chronic stress. In our present study, we determined whether an alteration GM is a decisive factor anxiety-like depression-like behavior its impact on brain neurochemistry. An antibiotic cocktail was used to deplete mice before they were colonized, via fecal transplantation (FMT), by control or had been exposed unpredictable mild stress (CUMS donors). The...
With the UC incidence increasing worldwide, it is of great importance to prevent and treat UC. However, efficient treatment options for are relatively limited. Due potentially serious adverse effects existing drugs, there an demand alternative candidate resources from natural functional foods. Astragalin (AG) a type anti-inflammatory flavonoid, with Moringa oleifera Cassia alata being its main source. In this study, we investigated therapeutic AG in mice dextran sulfate sodium (DSS)-induced...
Changes in the gut microenvironment may influence pathogenesis of autism spectrum disorders (ASD). Here, we investigated composition microbiota and metabolites children with ASD. Ninety-two ASD 42 age-matched exhibiting typical development (TD) were enrolled two-stage study. In discovery stage, shotgun metagenomic sequencing liquid chromatography-mass spectrometry (LC-MS) performed simultaneously on fecal samples obtained from 43 group 31 TD group. Systematic bioinformatic analyses to...
We investigated the local immune status and its prognostic value in lung adenocarcinoma. In total, 513 adenocarcinoma samples from TCGA ImmPort databases were collected analyzed. The R package coxph was employed to mine immune-related genes that significant indicators using both univariate multivariate analyses. software glmnet then used for Lasso Cox regression analysis, a prognosis prediction model constructed adenocarcinoma; clusterProfiler selected functional gene annotations KEGG...
Abstract As an important post-translational modification, ubiquitination mediates ∼80% of protein degradation in eukaryotes. The degree is tightly determined by the delicate balance between specific ubiquitin ligase (E3)-mediated and deubiquitinase-mediated deubiquitination. In 2017, we developed UbiBrowser 1.0, which integrated database for predicted human proteome-wide E3–substrate interactions. Here, to meet urgent requirement E3/deubiquitinase–substrate interactions (ESIs/DSIs) multiple...
Immune checkpoint inhibitors have greatly improved the prognoses of diverse advanced malignancies, including gastric and gastroesophageal junction (G/GEJ) cancer. However, role anti-programmed cell death protein-1 treatment in neoadjuvant setting remains unclear. This phase 2 study aimed to evaluate sintilimab plus CapeOx as a regimen patients with resectable G/GEJ adenocarcinoma. Eligible adenocarcinoma stage cT3-4NanyM0 were enrolled. Patients received (3 mg/kg for cases <60 kg or 200...
Autoimmune diseases such as ankylosing spondylitis (AS) can be driven by emerging neoantigens that disrupt immune tolerance. Here, we developed a workflow to profile posttranslational modifications involved in neoantigen formation. Using mass spectrometry, identified panel of cysteine residues differentially modified carboxyethylation required 3-hydroxypropionic acid generate patients with AS. The lysosomal degradation integrin αIIb [ITGA2B (CD41)] carboxyethylated at Cys96 (ITGA2B-ceC96)...
Abstract Despite the intense CD8+ T-cell infiltration in tumor microenvironment of nasopharyngeal carcinoma, anti-PD-1 immunotherapy shows an unsatisfactory response rate clinical trials, hindered by immunosuppressive signals. To understand how microenvironmental characteristics alter immune homeostasis and limit efficacy here we establish a multi-center single-cell cohort based on public data, containing 357,206 cells from 50 patient samples. We reveal that carcinoma enhance development...
Silicosis is a progressive inflammatory disease with poorly defined mechanisms and limited therapeutic options. Recent studies found that microRNAs (miRNAs) circular RNAs (circRNAs) were involved in the development of respiratory diseases; however, function non-coding silicosis was still needed to be further explored. We miR-223-3p significantly decreased macrophages lung tissues mice after silica treatment, which consistent results GEO database microarray analysis. Notably, NLRP3 target...
As one of the most salt-sensitive crops, strawberry production is severely limited by salt stress. γ--aminobutyric acid (GABA) has been reported to play an important role in immune response plants. In this study, physiological and transcriptomic changes seedlings treated with GABA under stress were investigated explore effect on tolerance. The results showed that exogenous maintained high osmolyte levels, increased antioxidant capacity, decreased ROS levels leaves stress; MDA was reduced...
Seizure is a common presenting manifestation and plays an important role in the clinical presentation quality of life for patients with low-grade gliomas (LGGs). The authors set out to identify factors that influence preoperative seizure characteristics postoperative control. Cases involving adult who had undergone initial surgery LGGs single institution between 2005 2009 were retrospectively reviewed. Univariate multivariate logistic regression analyses used associated seizures Of 508...