A5100371482- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Cancer Cells and Metastasis
- RNA regulation and disease
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Single-cell and spatial transcriptomics
- Cancer, Hypoxia, and Metabolism
- Nanoplatforms for cancer theranostics
- Gene Regulatory Network Analysis
- Cancer, Stress, Anesthesia, and Immune Response
- Cervical Cancer and HPV Research
- Traditional Chinese Medicine Studies
- Inflammatory Biomarkers in Disease Prognosis
- Esophageal Cancer Research and Treatment
- Bioinformatics and Genomic Networks
- Peroxisome Proliferator-Activated Receptors
- Plant Stress Responses and Tolerance
- Melanoma and MAPK Pathways
- Galectins and Cancer Biology
- Mathematical Biology Tumor Growth
- Acupuncture Treatment Research Studies
- Metabolism, Diabetes, and Cancer
- Plant Gene Expression Analysis
- Cancer, Lipids, and Metabolism
Ji Hua Laboratory
2023-2025
University of Hong Kong
2018-2025
University of Hong Kong - Shenzhen Hospital
2021-2025
Shandong Agricultural University
2025
Chinese University of Hong Kong
2025
Beijing Chest Hospital
2024
Capital Medical University
2024
Tianjin University of Traditional Chinese Medicine
2024
Wuxi People's Hospital
2021
Nanjing Medical University
2021
Abstract The tumor microenvironment (TME) of nasopharyngeal carcinoma (NPC) harbors a heterogeneous and dynamic stromal population. A comprehensive understanding this tumor-specific ecosystem is necessary to enhance cancer diagnosis, therapeutics, prognosis. However, recent advances based on bulk RNA sequencing remain insufficient construct an in-depth landscape infiltrating cells in NPC. Here we apply single-cell 66,627 from 14 patients, integrated with clonotype identification T B cells....
Lymph node metastasis, the leading cause of mortality in esophageal squamous carcinoma (ESCC) with a highly complex tumor microenvironment, remains underexplored. Here, transcriptomes 85 263 single cells are analyzed from four ESCC patients lymph metastases. Strikingly, it is observed that metastatic microenvironment undergoes emergence or expansion interferon induced IFIT3+ T, B cells, and immunosuppressive such as APOC1+ APOE+ macrophages myofibroblasts expression immunoglobulin genes...
Abstract Despite the intense CD8+ T-cell infiltration in tumor microenvironment of nasopharyngeal carcinoma, anti-PD-1 immunotherapy shows an unsatisfactory response rate clinical trials, hindered by immunosuppressive signals. To understand how microenvironmental characteristics alter immune homeostasis and limit efficacy here we establish a multi-center single-cell cohort based on public data, containing 357,206 cells from 50 patient samples. We reveal that carcinoma enhance development...
Background and Aims: Deregulation of adenosine-to-inosine editing by adenosine deaminase acting on RNA 1 (ADAR1) leads to tumor-specific transcriptome diversity with prognostic values for HCC. However, ADAR1 editase-dependent mechanisms governing liver cancer stem cell (LCSC) generation maintenance have remained elusive. Approach Results: RNA-seq profiling identified ADAR1-responsive recoding events in HCC showed frequency GLI1 , rather than transcript abundance was clinically relevant....
Organ-specific colonization suggests that specific cell-cell recognition is essential. Yet, very little known about this particular interaction. Moreover, tumor cell lodgement requires binding under shear stress, but not static, conditions. Here, we successfully isolate the metastatic populations of cancer stem/tumor-initiating cells (M-CSCs). We show M-CSCs tether more and roll slower than non-metastatic (NM)-CSCs, thus resulting in preferential to peritoneal mesothelium ascitic fluid...
Nasopharyngeal carcinoma (NPC) is one of the common head and neck cancers in Southern China Southeast Asia. Although current studies have adequately characterized tumor microenvironment (TME) NPC, little attention has been paid to how cell-cell interactions within TME promote tumorigenesis. In this study, it found that C1q+ tumor-associated macrophages (TAMs) are significantly enriched NPC tumors. Moreover, both TAMs elevated C1q expression associated with progression poor prognosis...
Abstract Lymph node (LN) metastasis is a pivotal step in the progression of esophageal squamous cell carcinoma (ESCC) and associated with poor clinical outcomes. Despite its significance, mechanisms underlying early colonization LNs by tumor cells remain insufficiently understood. In this study, we utilized human xenograft model spontaneous LN performed single-cell RNA sequencing to analyze transcriptomes from primary tumors metastases. A rare subset metastasis-initiating (MICs) stem-like...
Cancer stem cells (CSCs) are responsible for tumorigenesis, therapeutic resistance, and metastasis in hepatocellular cancer (HCC). Cancer/testis antigen Maelstrom (MAEL) is implicated the formation of CSC phenotypes, while exact role underlying mechanism remain unclear. Here, we found upregulation MAEL HCC, with its expression negatively correlated survival outcome. Functionally, promoted tumor cell aggressiveness, stem-like potentials, resistance to sorafenib HCC lines. Transcriptional...
The application of acupuncture and moxibustion in alleviating the adverse effects chemotherapy drugs has been widely recognized at home abroad, but studies have rarely summarized for enhanced anti-tumor effect its mechanism to synergize drugs. This paper reviewed clinical basic on synergism with recent years. It was found that synergized can suppress cancer a certain extent improve quality life patients. combined is related promoting tumor cell apoptosis, improving immune vascular...
Co-expression network may contribute to better understanding molecular interaction patterns underlying cellular processes. To explore microRNAs (miRNAs) expression correlated with AF, we performed weighted gene co-expression analysis (WGCNA) based on the dataset GSE28954. Thereafter, predicted target genes using experimentally verified databases (ENOCRI, miRTarBase, and Tarbase), overlapped differentially expressed (DEGs) from GSE79768 were identified as key genes. Integrated of association...
The integration of high-risk human papilloma virus (HPV) DNA into the genome has been implicated in cervical carcinogenesis and head neck squamous cell cancer. However, its role lung carcinoma is not well understood. In addition, tuberculosis (TB) cancer(LC) share similar clinical symptoms imaging features, increasing risk misdiagnosis. patient presented with a 16-month history hemoptysis, chest pain, occasional fatigue, without fever, chills, or mechanical damage autoimmune diseases....
Simple mutual-inhibition networks are frequently occurring motifs in transcriptional regulatory for cell lineage commitment. Stable attractors represent commitment states. However, how progenitor-specific transcription factors stabilise progenitor cells and commit them to different fates remains unexplained. In this study, the authors composed of regulation factors, develop associated mathematical model understand specific fate decisions made. Bifurcation analysis numerical simulation show...
e21203 Background: Radiotherapy (RT), surgical resection (SR), and immunotherapy (IT) as main therapies in lung cancer have either suppressive or stimulatory effects on the immune system. It’s still unclear mechanism involved systemic changes of cells blood. Peripheral blood lymphocyte subpopulations were useful markers for evaluating response tumor patients. Hence, we aimed to systematically investigate alteration during local evaluate antitumor treatment effects. Methods: Blood samples...