A5039244045- RNA modifications and cancer
- Cancer Cells and Metastasis
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Prostate Cancer Treatment and Research
- Cancer, Hypoxia, and Metabolism
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Epigenetics and DNA Methylation
- Lung Cancer Treatments and Mutations
- Cancer, Lipids, and Metabolism
- Metabolomics and Mass Spectrometry Studies
- Immunotherapy and Immune Responses
- Drug Transport and Resistance Mechanisms
- Cell Adhesion Molecules Research
- Prostate Cancer Diagnosis and Treatment
- Estrogen and related hormone effects
- Electrocatalysts for Energy Conversion
- Ferroptosis and cancer prognosis
- Sarcoma Diagnosis and Treatment
- Advanced battery technologies research
- FOXO transcription factor regulation
- Immune cells in cancer
- Bone Tumor Diagnosis and Treatments
- 3D Printing in Biomedical Research
Sichuan University
2021-2025
Zhejiang University
2021-2025
Southern University of Science and Technology
2019-2025
Jinan University
2016-2025
Chinese University of Hong Kong, Shenzhen
2021-2025
Institute of Crop Sciences
2025
Chinese Academy of Agricultural Sciences
2025
Ministry of Agriculture and Rural Affairs
2025
West China Hospital of Sichuan University
2021-2024
Shanghai First Maternity and Infant Hospital
2024
The role of cancer cell FOXP3 in tumorigenesis is conflicting. We aimed to study expression and regulation, function clinical implication human non-small lung (NSCLC).One hundred six patients with histologically-confirmed NSCLC who underwent surgery were recruited for the study. Tumor samples lines used examine its related molecules. Various functions performed. In vivo mouse tumor xenograft was confirm vitro results.NSCLC high level had a significant decrease overall survival...
Solid tumours respond poorly to immune checkpoint inhibitor (ICI) therapies. One major therapeutic obstacle is the immunosuppressive tumour microenvironment (TME). Cancer-associated fibroblasts (CAFs) are a key component of TME and negatively regulate antitumour T-cell response. Here, we aimed uncover mechanism underlying CAFs-mediated evasion develop novel strategies targeting CAFs for enhancing ICI efficacy in oesophageal squamous cell carcinoma (OSCC) colorectal cancer (CRC).Anti-WNT2...
This study aimed to validate whether infusion of GD2-specific fourth-generation safety-designed chimeric antigen receptor (4SCAR)-T cells is safe and CAR-T exert anti-glioblastoma (GBM) activity.A total eight patients with GD2-positive GBM were enrolled infused autologous 4SCAR-T cells, either through intravenous administration alone or combined intracavitary administration.4SCAR-T expanded for 1-3 weeks persisted at a low frequency in peripheral blood. Of the evaluable patients, four showed...
An attractive strategy to overcome multidrug resistance in cancer chemotherapy is suppress P-glycoprotein (P-gp), which a pump overproduced cells remove cytotoxic drugs from cells. In the present study, Ca 2+ -permeable channel TRPC5 was found be together with P-gp adriamycin-resistant breast cell line MCF-7/ADM. Suppressing activity/expression reduced induction and caused remarkable reversal of adriamycin an athymic nude mouse model human tumor, suppressing decreased growth tumor...
Although the treatment of brain tumors by targeting kinase-regulated macroautophagy/autophagy, is under investigation, precise mechanism underlying autophagy initiation and its significance in glioblastoma (GBM) remains to be defined. Here, we report that PAK1 (p21 [RAC1] activated kinase 1) significantly upregulated promotes GBM development. The Cancer Genome Atlas analysis suggests oncogenic role mainly associated with autophagy. Subsequent experiments demonstrate indeed serves as a...
Rationale: Cancer stem cells (CSCs) are considered to be essential for tumorigenesis, recurrence, and metastasis therefore serve as a biomarker tumor progression in diverse cancers.Recent studies have illustrated that specific miRNAs exhibit novel therapeutic potential by controlling CSC properties.miR-1275 is upregulated lung adenocarcinoma (LUAD) enhances its stemness.However, the underlying mechanisms not been elucidated.Methods: miRNA expression microarray of LUAD adjacent nontumor...
Tissue-engineered hydrogels have received extensive attention as their mechanical properties, chemical compositions, and biological signals can be dynamically modified for mimicking extracellular matrices (ECM). Herein, the synthesis of novel double network (DN) with tunable properties using combinatorial screening methods is reported. Furthermore, nanoengineered (NE) are constructed by addition ultrathin 2D black phosphorus (BP) nanosheets to DN multiple functions ECM microenvironment...
The highly intra-tumoral heterogeneity and complex cell origination of prostate cancer greatly limits the utility traditional bulk RNA sequencing in finding better biomarker for disease diagnosis stratification. Tissue specimens based single-cell holds great promise identification novel biomarkers. However, this technique has yet been used study heterogeneity.
Rationale: Methylation at the N6 position of adenosine (m6A) is most prevalent RNA modification within protein-coding mRNAs in mammals, and it a reversible with various important biological functions. The formation function m6A are regulated by methyltransferases (writers), demethylases (erasers), special binding proteins (readers) as key factors. However, underlying mechanisms gastrointestinal (GI) cancer remain unclear. Here, we performed comprehensive molecular profiling nine known...
Abstract Background Sepsis involves life-threatening organ dysfunction and is caused by a dysregulated host response to infection. No specific therapies against sepsis have been reported. Celastrol (Cel) natural anti-inflammatory compound that shows potential systemic inflammatory diseases. This study aimed investigate the pharmacological activity molecular mechanism of Cel in models endotoxemia sepsis. Methods We evaluated efficacy mice macrophage cultures treated with lipopolysaccharide...
Identification of potential novel targets for reversing resistance to Epidermal Growth Factor Receptor (EGFR)-tyrosine kinase inhibitors (EGFR-TKIs) holds great promise the treatment relapsed lung adenocarcinoma (LUAD). In present study, we aim investigate role methyltransferase-like 7B (METTL7B) in inducing EGFR-TKIs LUAD and whether it could be a therapeutic target resistance.METTL7B-overexpressed cell lines, gefitinib osimertinib-resistant Cell-Derived tumor Xenograft (CDX)...
Drug resistance and tumor recurrence remain clinical challenges in the treatment of urothelial carcinoma (UC). However, underlying mechanism is not fully understood. Here, we performed single-cell RNA sequencing identified a subset cells with epithelial-mesenchymal transition (EMT) features (EMT-UC), which significantly correlated chemotherapy cancer recurrence. To validate significance EMT-UC, constructed EMT-UC like by introducing overexpression two markers, Zinc Finger E-Box Binding...
Abstract Adaptation of cancer cells to a hypoxic microenvironment is important for their facilitated malignant growth and advanced development. One major mechanism mediating the response involves up‐regulation hypoxia‐inducible factor 1 ( HIF ‐1) expression, which controls reprogramming energy metabolism angiogenesis. Oestrogen‐related receptor‐ α ERR ) pivotal regulator cellular many biosynthetic pathways, has also been proposed be an promoting Warburg effect in cancer. We others have...