A5106733698- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Cancer Cells and Metastasis
- Immune cells in cancer
- Inflammatory Biomarkers in Disease Prognosis
- CAR-T cell therapy research
- Cancer, Hypoxia, and Metabolism
- Colorectal Cancer Treatments and Studies
- Glioma Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Cancer Genomics and Diagnostics
- Contact Dermatitis and Allergies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer therapeutics and mechanisms
- Cancer Research and Treatments
- Single-cell and spatial transcriptomics
- Wnt/β-catenin signaling in development and cancer
- Systemic Lupus Erythematosus Research
- Genomics, phytochemicals, and oxidative stress
- Acupuncture Treatment Research Studies
- Nutrition and Health in Aging
- Plant responses to water stress
- Aquaculture disease management and microbiota
- Melanoma and MAPK Pathways
Zhuzhou Central Hospital
2025
First People's Hospital of Chongqing
2025
Fudan University
2024
Center for Excellence in Molecular Plant Sciences
2024
Chinese Academy of Sciences
2024
Nanjing Medical University
2024
BGI Group (China)
2020-2024
BGI Research
2024
Shanghai Sixth People's Hospital
2024
Shanghai Jiao Tong University
2024
The role of cancer cell FOXP3 in tumorigenesis is conflicting. We aimed to study expression and regulation, function clinical implication human non-small lung (NSCLC).One hundred six patients with histologically-confirmed NSCLC who underwent surgery were recruited for the study. Tumor samples lines used examine its related molecules. Various functions performed. In vivo mouse tumor xenograft was confirm vitro results.NSCLC high level had a significant decrease overall survival...
The PD-L1/PD-1 pathway blockade-mediated immune therapy has shown promising efficacy in the treatment of multiple cancers including melanoma. present study investigated effects flavonoid apigenin on PD-L1 expression and tumorigenesis melanoma.The influence flavonoids melanoma cell growth apoptosis was using proliferation flow cytometric analyses. differential IFN-γ-induced STAT1 activation were examined curcumin apigenin-treated cells immunoblotting or immunofluorescence assays. sensitivity...
Significance Despite the discovery of von Hippel–Lindau ( VHL ) gene in 1993, and that inactivating germ-line mutations cause multiple kidney lesions, including clear-cell renal cell carcinoma (ccRCC), Vhl inactivation mouse does not lead to ccRCC a model has been lacking. We discovered BRCA1-associated protein-1 BAP1 two-hit tumor suppressor is mutated ccRCC, one allele frequently somatically codeleted with tumors. In mouse, Bap1 are on different chromosomes. show SIX homeobox 2 Six2...
Abstract The tumor microenvironment is a complex ecosystem formed by distinct and interacting cell populations, its composition related to cancer prognosis response clinical treatment. In this study, we have taken the advantage of two single‐cell RNA sequencing technologies (Smart‐seq2 DNBelab C4) generate an atlas 15,115 immune nonimmune cells from primary tumors hepatic metastases 18 colorectal (CRC) patients. We observed extensive changes in proportions functional states T B tissues,...
Myocardial ischemia/reperfusion injury (MIRI) is a significant challenge in the management of myocardial ischemic disease. Extensive evidence suggests that macrophage‑mediated inflammatory response may play vital role MIRI. Mesenchymal stem cells and, particular, exosomes derived from these cells, be key mediators and repair. However, whether protect heart by regulating polarization macrophages exact mechanisms involved are poorly understood. The present study aimed to determine secreted...
Abstract Epstein-Barr virus (EBV) has been detected in the tumor cells of several cancers, including some cases lung carcinoma (LC). However, genomic characteristics and diversity EBV strains associated with LC are poorly understood. In this study, we sequenced genomes isolated from four primary biopsy samples, designated LC1 to LC4. Comparative analysis demonstrated that were more closely related GD1 strain. Compared reference genome, a total 520 variations all, 498 substitutions, 12...
Brown planthopper (BPH) is the most destructive insect pest of rice. Drought detrimental environmental stress. BPH infestation causes adaxial leaf-rolling and bulliform cells (BCs) shrinkage similar to drought. The BC-related abaxially curled leaf1 (ACL1) gene negatively regulates resistance drought tolerance, with decreased cuticular wax in gain-of-function mutant ACL1-D. ACL1 shows an epidermis-specific expression. TurboID system multiple biochemical assays reveal that interacts...
Skin sensitization is an important toxicological endpoint for chemical hazard determination and safety assessment. Prediction of skin sensitizer had traditionally relied on data from rodent models. The development the adverse outcome pathway (AOP) associated alternative in vitro assays have reshaped assessment sensitizers. integration multiple as key events AOP has been shown to improved prediction performance. Current computational models predict mainly based vivo without incorporating...
The combined impact of nutritional and inflammatory status on survival cervical cancer patients remained unclear. This study aimed to construct a nomogram involving both indicators evaluate their potential correlation.
Poly(ADP‑ribose) polymerase‑1 (PARP‑1) plays a critical role in inflammatory pathways. The PARP‑1 inhibitor, 5‑aminoisoquinolinone (5‑AIQ), has been demonstrated to exert significant pharmacological effects. present study aimed further examine the potential mechanisms of 5‑AIQ mouse model dextran sodium sulfate (DSS)‑induced colitis. Colitis conditions were assessed by changes weight, disease activity index, colon length, histopathology and pro‑inflammatory mediators. colonic expression...
Retraction: “HCFU inhibits cervical cancer cells growth and metastasis by inactivating Wnt/β‐catenin pathway” from Journal of Cellular Biochemistry Ping Liu, Shuying Ma, Hua Huazhen Han, Shanshan Wang published online on 12 December 2017 in Wiley Online Library (wileyonlinelibrary.com), has been withdrawn agreement between the journal Editor Chief Gary S. Stein John Sons, Inc. The retraction agreed because authors are not responding to requests finalize their article for publication as...
Multidrug resistance-associated protein 1 (MRP1) plays a protective role in the etiology and progression of chronic obstructive pulmonary disease (COPD) which results from oxidative stress inflammation lung injury. The lower functional MRP1 activity is related to COPD development. Our previous study showed that Allyl isothiocyanate (AITC) induced expression dose-dependent manner. However, signaling pathway contributes upregulation by AITC unclear. In this study, specific inhibitors were used...
Yangyin Fuzheng Jiedu Prescription (YFJP), a formulated Chinese herbal medicine, has been used for several decades in the treatment of hepatocellular carcinoma (HCC). Previous studies have demonstrated its anti-tumor efficacy, but mechanism action remains uncharacterized. This study aims to evaluate therapeutic effect YFJP on H22 tumor-bearing mice. aimed A total 50 male mice were randomly divided into 6 groups and continuous administered either different doses or cyclophosphamide (CTX)...
A bstract Glioblastoma (GBM) exhibits populations of cells that drive tumorigenesis, treatment resistance, and disease progression. Cells with such properties have been described to express specific surface intracellular markers or exhibit functional features including being slow-cycling quiescent the ability generate proliferative progenies. In GBM, each these cellular fractions was shown harbor cardinal cancer stem 1-7 . this study we focus on comparison present evidence great phenotypic...