A5031979735- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Metal-Organic Frameworks: Synthesis and Applications
- Radiopharmaceutical Chemistry and Applications
- Crystallography and molecular interactions
- Metal complexes synthesis and properties
- Magnetism in coordination complexes
- Nanoplatforms for cancer theranostics
- Bone health and treatments
- Cancer Immunotherapy and Biomarkers
- Advanced biosensing and bioanalysis techniques
- Medical Imaging Techniques and Applications
- Click Chemistry and Applications
- Ferrocene Chemistry and Applications
- Photodynamic Therapy Research Studies
- Porphyrin and Phthalocyanine Chemistry
- Estrogen and related hormone effects
- Nanoparticle-Based Drug Delivery
- Peptidase Inhibition and Analysis
- Supramolecular Self-Assembly in Materials
- Mass Spectrometry Techniques and Applications
- Covalent Organic Framework Applications
- Medical Imaging and Pathology Studies
- Molecular Sensors and Ion Detection
- Cancer Research and Treatments
Key Laboratory of Nuclear Radiation and Nuclear Energy Technology
2020-2025
Xuzhou Medical College
2024-2025
Nanjing Medical University
2020-2025
Laboratory of Molecular Genetics
2015-2021
Wuxi Institute of Technology
2015-2021
Ministry Of Health
2016-2019
Nanjing University
2010-2015
Collaborative Innovation Center of Advanced Microstructures
2015
Although immunotherapy through programmed death 1/programmed ligand 1 (PD-1/PD-L1) checkpoint blockade has shown impressive clinical outcomes, not all patients respond to it. Recent studies have demonstrated that the expression level of PD-L1 in tumors is one factors correlate with PD-1/PD-L1 therapy. Herein, a <sup>68</sup>Ga-labeled single-domain antibody tracer, <sup>68</sup>Ga-NOTA-Nb109, was designed and developed for specific noninvasive imaging melanoma-bearing mouse model....
Two porous supramolecular isomeric frameworks show unique sorption properties, one with temperature dependent stepwise and hysteretic selective of CO(2) while the other shows gas uptake capacity for CO(2), N(2), H(2) CH(4) at low over N(2) around room temperature.
Five new metal complexes, [Zn3(L1)2(BTC)2]·6H2O (1), [Zn3(L1)(BTC)2] (2), [Cd3(L1)(BTC)2] (3), [Cd3(L2)(BTC)2]·4H2O (4), and [Cd3(L2)(BTC)2(H2O)2] (5), have been successfully synthesized by solvothermal reactions of corresponding salts with 1,3,5-benzenetricarboxylic acid (H3BTC) imidazole-containing ligands 1,3,5-tris(imidazol-1-ylmethyl)benzene (L1) 3,3′,5,5′-tetra(imidazol-1-yl)-1,1′-biphenyl (L2). The structures the complexes were determined single crystal X-ray diffraction analysis....
Four novel cobalt(II) coordination polymers [Co2(OA)(dib)2(H2O)] (1), [Co2(OA)(bbi)2]·3H2O (2), [Co3(HOA)2(bpe)2(H2O)6]·2H2O (3), and [Co2(OA)(dpe)(H2O)2] (4) were obtained by hydrothermal reactions of Co(NO3)2·6H2O with 3,3′,4,4′-oxidiphthalic acid (H4OA) corresponding N-donor ligands, namely, 1,4-di(1-imidazolyl)benzene (dib), 1,1′-(1,4-butanediyl)bis(imidazole) (bbi), 1,2-bis(4-pyridyl)ethane (bpe), 1,2-di(4-pyridyl)ethylene (dpe), respectively. Single crystal X-ray diffraction analysis...
Five novel Ru(<sc>ii</sc>)–N-heterocyclic carbenes (NHC) were synthesized and biologically evaluated, one of which showed superior activity against PC-3 cell lines 6 fold more than cisplatin.
Target-enabled bioorthogonal reaction and self-assembly of a small-molecule probe into supramolecules have shown promise for molecular imaging. In this paper, we report new stimuli-responsive scaffold (SF) controlling in situ by engineering the condensation between 2-cyanobenzothiazole cysteine. For probes with SF scaffold, intramolecular cyclization took place soon after activation, which could efficiently outcompete free cysteine even at low concentration result efficient aggregation...
Immunotherapy blocking programmed cell death protein 1/programmed ligand 1 (PD-1/PD-L1) pathway has achieved great therapeutic effect in the clinic, but overall response rate is not satisfactory. Early studies showed that to treatment and survival could be positively related PD-L1 expression tumors. Therefore, accurate measurement of will help screen cancer patients improve rate. A small molecular positron emission tomography (PET) probe [18F]LP-F containing a biphenyl moiety was designed...
Five new entangled metal−organic frameworks {[Co(H2L)2(HCOO)2] (1), [Ni(H2L)2(HCOO)2] (2), [Co(HL)2]·2H2O (3), [Ni(H2L)2(SO4)]·2H2O (4), and [Ag2(L)] (5)} were synthesized by reactions of the corresponding metal salts with rigid ligand 1,4-di(1H-imidazol-4-yl)benzene (H2L). These compounds characterized single crystal X-ray structural determination, IR, thermogravimetric analysis, powder diffraction. The isostructural behavior is observed between 1 2. Both 2 are 3D 3-fold inclined...
An exploration of reactions 3,3′,5,5′-tetra(1H-imidazol-1-yl)-1,1′-biphenyl (L) and 1,3,5-benzenetricarboxylic acid (H3BTC) with Co(II) salt has led to the formation three new complexes different framework structures, [Co2(L)(HBTC)2(μ2-H2O)(H2O)2]·3H2O (1), [Co3(L)2(BTC)2]·4H2O (2) [Co2(L)(BTC)(μ2-OH)(H2O)2]·2H2O (3). They were obtained as pH-dependent products. The H3BTC ligand is partially deprotonated in 1, but completely 2 3. Furthermore, a bridging OH− present Complex 1 consists...
A pH sensitive mesoporous silica nanocarrier, RuNHC@MSNs-CTS-Biotin (CTS = chitosan), is developed for the targeted delivery and controlled release of a ruthenium(<sc>ii</sc>) N-heterocyclic carbene (RuNHC) complex.
Despite advances in immunotherapy for the treatment of cancers, not all patients can benefit from programmed cell death ligand 1 (PD-L1) immune checkpoint blockade therapy. Anti-PD-L1 therapeutic effects reportedly correlate with PD-L1 expression level; hence, accurate detection guide to achieve better effects. Therefore, based on high affinity antibody Nb109, a new site-specifically radiolabeled tracer, 68Ga-NODA-cysteine, aspartic acid, and valine (CDV)-Nb109, was designed synthesized...
Nowadays, one of the most effective methods tumor immunotherapy is blocking programmed cell death protein 1/programmed ligand 1 (PD-1/PD-L1) immune checkpoints. However, there still a significant challenge in selecting patients to benefit from checkpoint therapies. Positron emission tomography (PET), noninvasive molecular imaging technique, offers new approach accurately detect PD-L1 expression and allows for better prediction response PD-1/PD-L1 target immunotherapy. Here, we designed...
Six new metal–organic coordination polymers [Ni(L)(adip)(H2O)] (1), [Co(L)(adip)]·H2O (2), [Cd2(L)(adip)2] (3), [Ni(L)(oxba)]·H2O (4), [Co(L)(obea)]·H2O (5) and [Mn3(L)2(bta)2]·2H2O (6) were synthesized by reactions of the corresponding metal salt with rigid ligand 1,4-di(1H-imidazol-4-yl)benzene (L) different multi-carboxylic acids adipic acid (H2adip), 4,4′-oxybis(benzoic acid) (H2oxba), 1,2-phenylenediacetic (H2obea), benzene-1,3,5-triacetic (H3bta), respectively. The structures complexes...
Five zinc(II) coordination polymers with 5-(4H-1,2,4-triazol-4-yl)benzene-1,3-dicarboxylic acid (H2L), {[Zn2(L)2(H2O)4]·3H2O}n (1), {[Zn2(L)2(H2O)2]·3H2O}n (2), [Zn(L)(H2O)]n (3), (4) and {[Zn10(L)8(μ3-O)2(H2O)6]·8H2O}n (5), have been synthesized structurally characterized. The compounds exhibit unprecedentedly high structural diversity. 1, 2, 3 5 are obtained by temperature-dependent synthesis 4 is selectively induced addition of 1,3,5-benzenetricarboxylic acid. In the two-dimensional (2D)...
A series of Cu(II) complexes showed unprecedented reversible cascades single-crystal-to-single-crystal (SCSC) transformations, and more interestingly, very rapid crystal dynamic processes were observed in this system via the substitution coordinating components without loss single crystallinity.
Glioblastoma is one of the most common primary tumor types central nervous system (CNS) with high malignance and lethality.Although many treatment options are currently available, therapy brain cancers remains challenging because blood-brain-barrier (BBB) which prevents chemotherapeutics into CNS.In this work, a poly(amidoamine) dendrimer-based carrier was fabricated modified angiopep-2 (Ang2) peptide that has been demonstrated to bind low density lipoprotein receptor-relative protein-1...
A hybrid metallic prodrug for targeting PR-positive breast cancer therapy was prepared, which revealed significantly <italic>in vivo</italic> antitumor effect.