A5086335546- Chronic Obstructive Pulmonary Disease (COPD) Research
- Metabolomics and Mass Spectrometry Studies
- Traditional Chinese Medicine Analysis
- Ginseng Biological Effects and Applications
- Genomics, phytochemicals, and oxidative stress
- Pediatric health and respiratory diseases
- Cancer-related molecular mechanisms research
- Cancer Mechanisms and Therapy
- Traditional Chinese Medicine Studies
- Natural product bioactivities and synthesis
- Autophagy in Disease and Therapy
- Inflammation biomarkers and pathways
- Gut microbiota and health
- Drug Transport and Resistance Mechanisms
- Pharmacological Effects of Natural Compounds
- Cancer, Hypoxia, and Metabolism
- Medical Research and Treatments
- Signaling Pathways in Disease
- Plant-based Medicinal Research
- Cancer, Lipids, and Metabolism
- Healthcare and Venom Research
- Ferroptosis and cancer prognosis
- Medicinal Plant Pharmacodynamics Research
- Asthma and respiratory diseases
- Sulfur Compounds in Biology
Anhui University of Traditional Chinese Medicine
2016-2025
Chinese Center For Disease Control and Prevention
2024
Anhui Provincial Department of Education
2023
Anhui University
2018
Shandong Academy of Chinese Medicine
2017
State Administration of Traditional Chinese Medicine of the People's Republic of China
2015
Chronic obstructive pulmonary disease (COPD), a prevalent, progressive respiratory disease, has become the third leading cause of death globally. Increasing evidence suggests that intestinal and microbiota dysbiosis is associated with COPD. Researchers have shown T helper (Th) 17/regulatory (Treg) imbalance involved in Qibai Pingfei Capsule (QBPF) traditional Chinese medicine used to treat COPD clinically China. However, effects QBPF intervention on Th17/Treg balance gut lung are still...
Qi-Yu-San-Long decoction (QYSLD), a traditional Chinese medicine (TCM) prescription, consisting of ten types herbal which has significant clinical efficacy in the treatment non-small cell lung cancer (NSCLC). However, bioactive ingredients QYSLD remain unclear, due to their "multi-ingredients" and "multi-targets" features. This study aimed construct spectrum-effect correlation analysis model screen potential active components QYSLD. A fingerprint method based on ultra-high performance liquid...
In this work, an untargeted metabolomic method based on ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-QTOF/MS) in MS E (E represents collision energy) mode was exploited to determine the dynamic metabolic alterations plasma of male C57BL/6 mice during onset and development lung carcinoma. Plasma samples were collected from control model (male experimentally inoculated with Lewis carcinoma cells) at 7 14 days post-inoculation (DPI). As a...
Chronic obstructive pulmonary disease (COPD) exacerbations accelerate loss of lung function and increased mortality. The complex nature COPD presents challenges in accurately predicting understanding frequent exacerbations. present study aimed to assess the metabolic characteristics exacerbation (COPD‑FE) phenotype, identify potential biomarkers associated with COPD‑FE risk evaluate underlying pathogenic mechanisms. An internal cohort 30 stable patients was recruited. A widely targeted...
Lung carcinogenesis (LC) is a kind of disease, which threatens human health seriously. Metabolomic research on bio-fluids and tissues crucial for elucidating the pathogenesis LC understanding therapeutic mechanisms medicines. In this study, we established rat model by induction with urethane. The anti-tumor effect Qi-Yu-San-Long decoction (QYSLD) was assessed through morphology changes, histopathological examination, inflammation levels. Utilizing metabolomics technique based...
ABSTRACT Aim Chronic obstructive pulmonary disease (COPD) is a critical disease, with lung function closely linked to severity. This study aimed evaluate the clinical efficacy of treatments for stable COPD in patients Grades I and II. Patients Methods We conducted multicenter, randomized, double‐blind, placebo‐controlled trial (registration number: NCT01486186). A total 502 were randomly assigned an experimental group ( n = 251, treated Bufei, Bufei Jianpi, Yishen granules based on...
ABSTRACT Aim Chronic Obstructive Pulmonary Disease (COPD) is a common chronic airway disease that can lead to decreased lung function in patients. It places heavy economic burden on patients and society. Traditional Chinese medicine (TCM) Western have played important roles managing COPD. We aimed develop an evidence‐based guideline for treating COPD with Medicine. Methods formed panel of multidisciplinary experts. The clinical questions were identified based two rounds issue solicitation...
To explore the mechanism of Shenqi Buzhong (SQBZ) Formula for alleviating mitochondrial dysfunction in a rat model chronic obstructive pulmonary disease (COPD) light AMPK/SIRT1/PGC-1α pathway. Fifty male SD models COPD, established by intratracheal lipopolysaccharide (LPS) instillation, exposure to cigarette smoke, and gavage Senna leaf infusion, were randomized into 5 groups (n=10) treatment with saline (model group), SQBZ at low, moderate high doses (3.08, 6.16 12.32 g/kg, respectively),...
Arisaema heterophyllum Blume (AhBl) is one of the valued medicinal plants. However, its genetic information limited, which impedes further studies this valuable resource. To investigate genes involved in isoflavonoid biosynthesis, we deeply performed transcriptome sequencing for AhBl. An average 10.98 Gb clean reads were obtained based on root, tuber and leaf tissues, 109,937 unigenes yielded after de novo assembly. In total, 72,287 those annotated at least public database. The numbers...
Lung cancer is one of the most fatal cancers due to its high metastatic rate. Traditional Chinese medicine has been used in patients for decades improve quality life and prolong survival time. The present study a novel Qiyusanlong (QYSL) decoction composed 10 kinds including astragalus membranaceus (Huangqi), polygonatumod oratum (yuzu), scolopendra (tianlong), pberetima (dilong), solanum nigrum (longkui), herbahedyotis (baihushecao), semen coicis (yiyiren), euphorbia helioscopia (zeqi),...
Abstract Background Pingchuanning decoction is a well‐known traditional Chinese medicine for the treatment of airway inflammatory diseases, including asthma. However, potential mechanism by which contributes to amelioration inflammation remains unknown. Methods A rat model asthma was well established inducing ovalbumin. Lipopolysaccharide‐stimulated tracheal epithelial (RTE) cells were used as cellular model. Lung histopathology and goblet cell hyperplasia assessed hematoxylin‐eosin (HE)...
Multidrug resistance-associated protein 1 (MRP1), a member of the ATP-binding cassette (ABC) superfamily transporters, plays an important role in normal lung physiology by protecting cells against oxidative stress and toxic xenobiotics. The present study investigates effects allyl isothiocyanate (AITC) on MRP1 mRNA expression transporter activity immortalised human bronchial epithelial cell line 16HBE14o-. 16HBE14o- that were treated with analysed real-time PCR assay Western blotting....
To evaluate the effect of Liuweibuqi capsules on chronic obstructive pulmonary disease (COPD) through JAK/STAT pathway.Lung function was measured with a spirometer. Changes in lung histology were observed using H&E staining. Cigarette smoke extract combined lipopolysaccharide (CSE+LPS) used to establish cellular COPD model. Cytokine levels determined ELISA, and changes pathway evaluated western blotting. The CCK8 method flow cytometry measure cell viability apoptosis, respectively.Liuweibuqi...