A5100388723- Microbial Natural Products and Biosynthesis
- Caveolin-1 and cellular processes
- Autophagy in Disease and Therapy
- Endoplasmic Reticulum Stress and Disease
- Marine Sponges and Natural Products
- Healthcare and Venom Research
- Cell Adhesion Molecules Research
- Hippo pathway signaling and YAP/TAZ
- Organoboron and organosilicon chemistry
- Fungal Biology and Applications
- Cellular Mechanics and Interactions
- Berberine and alkaloids research
- Aquaculture disease management and microbiota
- Circular RNAs in diseases
- Cardiac Fibrosis and Remodeling
- MicroRNA in disease regulation
- Aquaculture Nutrition and Growth
- Plant-Microbe Interactions and Immunity
- Synthesis and Biological Activity
- Apelin-related biomedical research
- Inflammatory mediators and NSAID effects
- RNA modifications and cancer
- melanin and skin pigmentation
- Extracellular vesicles in disease
- Flavonoids in Medical Research
Xuzhou Medical College
2022-2025
Leiden University
2025
Anhui University of Traditional Chinese Medicine
2023-2025
Southern University of Science and Technology
2024
Minzu University of China
2024
Shenyang Medical College
2021-2024
Nankai University
2024
Yidu Central Hospital of Weifang
2024
Tianjin Normal University
2024
Dalian Medical University
2019-2024
Actinomycetes are important organisms for the biosynthesis of valuable natural products. However, only a limited number well-characterized native constitutive promoters from actinomycetes available construction and engineering large biochemical pathways. Here, we report discovery characterization 32 candidate identified Streptomyces albus J1074 by RNA-seq analysis. These were cloned characterized using streptomycete reporter gene, xylE, encoding catechol 2,3-dioxygenase. The strengths strong...
More evidence is emerging of the roles long non-coding RNAs (lncRNAs) play as regulatory factors in a variety biological processes, but mechanisms underlying function lncRNAs acute myocardial infarction (AMI) have not been explicitly delineated. The present study identified lncRNA 2810403D21Rik/AK007586/Mirf (myocardial infarction-regulatory factor), that inhibited macroautophagy/autophagy by modulating Mir26a (microRNA 26a). Inhibition led to cardiac injury both vitro and vivo, whereas...
Silacycles have exhibited significant potential for application in the fields of medicinal chemistry, agrochemistry, and materials science. Accordingly, development effective methods synthesizing these compounds has attracted increasing attention. Here, we report an efficient Cu-catalyzed enantioselective hydrosilylation arylmethylenecyclopropanes with hydrosilanes, that allows rapid assembly various enantioenriched carbon- silicon-stereogenic silacyclopentanes good yields excellent...
Acute myocardial infarction (AMI) is a devastating cardiovascular disease with high rate of morbidity and mortality, partly due to enhanced arrhythmogenicity. MicroRNAs (miRNAs) have been shown participate in the regulation cardiac ion channels associated arrhythmias. The purpose this study was test our hypothesis that miR-223-3p contributes electrical disorders AMI via modulating KCND2, gene encoding voltage-gated channel Kv4.2 carries transient outward K+ current Ito.AMI model established...
Programmed cell death (PCD) is a critical biological process involved in many important processes, and defects PCD have been linked with numerous human diseases. In recent years, the protein architecture different subroutines has explored, but our understanding of global network organization noncoding RNA (ncRNA)-mediated system limited ambiguous. Hence, we developed comprehensive bioinformatics resource (ncRDeathDB, www.rna-society.org/ncrdeathdb ) to archive ncRNA-associated interactions....
Abstract Berberine (BBR) is a natural isoquinoline alkaloid, which used in traditional medicine for its anti‐microbial, anti‐protozoal, anti‐diarrhoeal activities. interacts with DNA and displays anti‐cancer activities, yet effects on cellular repair synthetic treatments chemotherapeutic drugs remain unclear. In this study, we investigated the of BBR sensitization breast cancer cells to different types damage anti‐tumoural drugs. We found arrested cell cycle S phase induced breaks. Cell...
The blood-brain barrier (BBB) is a protective for brain safety, but it also major obstacle to the delivery of drugs cerebral parenchyma such as hippocampus, hindering treatment central nervous system diseases Alzheimer's disease (AD). In this work, an anti-AD brain-targeted nanodrug by co-loading icariin (ICA) and tanshinone IIA (TSIIA) into Aniopep-2-modified long-circulating (Ang2-ICA/TSIIA) liposomes was developed. Low-density lipoprotein receptor-related protein-1 (LRP1) receptor...
Banana (Musa spp.) is an important fruit crop cultivated in most tropical countries. Fusarium wilt caused by oxysporum f. sp. cubense race 4 (Foc TR4) the destructive fungal disease. Biocontrol using endophytic microorganisms considered as a safety and sustainable strategy. Actinomycetes have potential for production of diverse metabolites. Isolation actinomycetes with high efficiency broad-spectrum antagonism key exploring biocontrol agents. Our previous study showed that total 144 were...
Abstract Background Atherosclerosis preferentially develops in regions of disturbed flow (DF). Emerging evidence indicates that yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ), which are both effectors the Hippo pathway, sense different blood patterns regulate atherosclerotic lesions. We previously found methotrexate (MTX) reduces in-stent neoatherosclerosis, decreases plaque burden, has an effect on local fluid shear stress. Here, we investigated...
Long non-coding RNAs (lncRNAs) play vital roles in the metastasis and invasion of cancer cells. Systematic analysis ovarian (OvCa) expression profiles suggests that deregulation lncRNA AC004988.1, designated promoting transition-associated (PTAL), is involved OvCa progression. However, underlying mechanism PTAL remains unknown. In this study, we showed was significantly upregulated mesenchymal subtype samples compared with epithelial from TCGA serous datasets. positively correlated...
Glioma is the most common and deadly primary malignant tumor in adults. Treatment outcomes are ungratified due to presence of blood-brain barrier (BBB), glioma stem cells (GSCs) multidrug resistance (MDR). Docetaxel (DTX) considered as a potential drug for treatment brain tumor, but its effectiveness limited by low bioavailability resistance. Tetrandrine (TET) reverses chemotherapy drugs. Borneol (BO) modified micelles has been shown promote DTX plus TET cross BBB, allowing better act on...
Pulmonary fibrosis is a progressive disease characterized by epithelial cell damage, fibroblast proliferation, excessive extracellular matrix (ECM) deposition, and lung tissue scarring. Melatonin, hormone produced the pineal gland, plays an important role in multiple physiological pathological responses organisms. However, function of melatonin development bleomycin-induced pulmonary injury poorly understood. In present study, we found that significantly decreased mortality restored alveolar...
Neuropsychological performance was examined in healthy elderly participants administered the cholinesterase inhibitor donepezil. Of principal interest examination of sensitivity a series neuropsychological measures to detect cognitive changes after drug administration using typical phase I research parameters (eg, small sample over short treatment period). In this double-blind parallel study period 6 weeks, 26 (aged 55 75 years) were randomized into 1 2 arms (14 donepezil and 12 placebo)...
Caveolin-1, which has been proposed as a candidate tumor suppressor, plays regulatory role in several signaling pathways. The importance of caveolin-1 endothelial cells angiogenesis confirmed. clinicopathologic significance expression and its correlation with remains unknown mucoepidermoid carcinoma (MEC) the salivary glands.Based on an immunohistochemical study, levels vascular growth factor (VEGF) intratumoral microvessel density (MVD) (labeled by CD34) 75 patients MEC were investigated,...
Obesity is a common nutritional disorder associated with type 2 diabetes, cardiovascular diseases, dyslipidemia, and certain cancers. In this study, we investigated the effects of Citrus ichangensis peel extract (CIE) in high-fat (HF) diet-induced obesity mice. Female C57BL/6 mice were fed chow diet or an HF alone supplemented 1% w/w CIE for 8 weeks. We found that treatment could lower blood glucose level improve tolerance. HF+CIE group, body weight gain, serum total cholesterol (TC)...