A5100458378- Autophagy in Disease and Therapy
- Gout, Hyperuricemia, Uric Acid
- Endoplasmic Reticulum Stress and Disease
- Cervical Cancer and HPV Research
- Sirtuins and Resveratrol in Medicine
- Parkinson's Disease Mechanisms and Treatments
- Calcium signaling and nucleotide metabolism
- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Cardiovascular Function and Risk Factors
- Mitochondrial Function and Pathology
- Neuroinflammation and Neurodegeneration Mechanisms
- MicroRNA in disease regulation
- Virology and Viral Diseases
- Advanced Glycation End Products research
- Nutrition and Health in Aging
- Histone Deacetylase Inhibitors Research
- Cell death mechanisms and regulation
- Inflammasome and immune disorders
- Heme Oxygenase-1 and Carbon Monoxide
- Metabolism, Diabetes, and Cancer
- Pancreatitis Pathology and Treatment
- Viral gastroenteritis research and epidemiology
- Nonmelanoma Skin Cancer Studies
- RNA modifications and cancer
First Affiliated Hospital of Chengdu Medical College
2023-2025
Jining First People's Hospital
2025
Hunan University
2025
The Affiliated Yongchuan Hospital of Chongqing Medical University
2025
Chongqing Medical University
2025
Affiliated Hospital of Hebei University
2025
Mayo Clinic
2020-2024
Jiangsu Province Hospital
2024
Nanjing Medical University
2024
Southern Medical University
2015-2024
Inflammation participates centrally in all stages of atherosclerosis (AS), which begins with inflammatory changes the endothelium, characterized by expression adhesion molecules. Resveratrol (RSV) is a naturally occurring phytoalexin that can attenuate endothelial inflammation; however, exact mechanisms have not been thoroughly elucidated. Autophagy refers to normal process cell degradation proteins and organelles, protective against certain injuries. Thus, we intended determine role...
Inflammation and autophagy are two critical cellular processes. The relationship between these processes is complex includes the suppression of inflammation by autophagy. However, signaling mechanisms that relieve this autophagy-mediated inhibition to permit a beneficial inflammatory response remain unknown. We find LPS triggers p38α mitogen-activated protein kinase (MAPK)–dependent phosphorylation ULK1 in microglial cells. This inhibited activity, preventing it from binding downstream...
Owing to the dominant functions of mitochondria in multiple cellular metabolisms and distinct types regulated cell death, maintaining a functional mitochondrial network is fundamental for homeostasis body fitness response physiological adaptations stressed conditions. The process mitophagy, which dysfunctional or superfluous are selectively engulfed by autophagosome subsequently degraded lysosome, has been well formulated as one major mechanisms quality control. To date, PINK1-PRKN-dependent...
Abstract During the past norovirus (NoV) epidemic season, a new GII.17 variant emerged as predominant NoV strain, surpassed GII.4 NoVs, causing outbreaks of acute gastroenteritis (AGE) in China. Here we report study an AGE outbreak elementary school December 2014 caused by to explore potential mechanism behind sudden epidemics NoV. A total 276 individuals were sick with typical infection symptoms vomiting (93.4%), abdominal pain (90.4%), nausea (60.0%) and diarrhea (10.4%) at attack rate...
Programmed cell death (PCD) is a critical biological process involved in many important processes, and defects PCD have been linked with numerous human diseases. In recent years, the protein architecture different subroutines has explored, but our understanding of global network organization noncoding RNA (ncRNA)-mediated system limited ambiguous. Hence, we developed comprehensive bioinformatics resource (ncRDeathDB, www.rna-society.org/ncrdeathdb ) to archive ncRNA-associated interactions....
Aims: Diabetic nephropathy (DN) is the principal cause of mortality and morbidity in diabetic patients, progression which correlates best with tubulointerstitial fibrosis (TIF). Advanced oxidation protein products (AOPPs) have been detected patients chronic renal failure, causing injuries to proximal tubular epithelial cells. CD36, a known receptor for AOPP, an important modulator lipid homeostasis, predisposing damage. However, whether AOPPs induce lipotoxicity via CD36 pathway remains...
With the increasing use of silver nanoparticles (AgNPs) in biological materials, cytotoxicity caused by these particles has attracted much attention. However, molecular mechanism underlying AgNP remains unclear. In this study, we aimed to systematically investigate toxicity induced exposure lung adenocarcinoma A549 cell line at subcellular and signaling pathway levels elucidate related mechanism. The survival rate cells exposed AgNPs 0, 20, 40, 80, 160 μg/mL for 24 or 48 h decreased a dose-...
Abstract Glomerulonephritis is the one of major causes end‐stage kidney disease, whereas pathological process glomerulonephritis still not completely understood. Single‐cell RNA sequencing (scRNA‐seq) emerges to be a powerful tool evaluate full heterogeneity diseases. To reveal cellular gene expression profiles glomerulonephritis, we performed scRNA‐seq 2 human transplantation donor samples, 4 1 malignant hypertension (MH) sample and chronic interstitial nephritis (CIN) sample, all tissues...
This study aimed to investigate whether ischemic postconditioning (IpostC) alleviates cerebral ischemia/reperfusion (I/R) injury involved in autophagy. Adult Sprague-Dawley rats were divided into five groups: sham (sham surgery), I/R (middle artery occlusion [MCAO] for 100 min, then reperfusion), IpostC (MCAO reperfusion 10 MCAO IpostC+3MA (3-methyladenine, an autophagy inhibitor, administered 30 min before first and IpostC+Veh (vehicle control group). Infarct volume was measured using...
During proteasomal stress, cells can alleviate the accumulation of polyubiquitinated proteins by targeting them to perinuclear aggresomes for autophagic degradation, but mechanism underlying activation this compensatory pathway remains unclear. Here we report that PINK1-s, a short form Parkinson disease (PD)-related protein kinase PINK1 (PTEN induced putative 1), is major regulator aggresome formation. PINK1-s extremely unstable due its recognition N-end rule pathway, and tends accumulate in...
To evaluate the association between serum uric acid and obesity among university students who participated in routine health screening 2013.In this cross-sectional study, 3529 subjects were analyzed. Obesity categories classified by BMI levels references China. And quartiles. Two-sample T-test Wilcoxon Rank sum test used to compare age, biochemical anthropometric parameters of two genders. correlation analyze relationship obesity.There 1285 males (mean 19.8 ± 1.3 years) 2244 females 19.9...
Coronary artery disease (CAD) is an immune-mediated chronic inflammatory mainly caused by atherosclerosis. The aims of this study were to investigate the role interleukin-27 (IL-27) in patients with CAD and severity coronary lesions, which was evaluated Gensini score biosynthesis IL-27 oxidized low-density lipoprotein (ox-LDL) vitro using monocyte-derived dendritic cells (DCs). To aim, plasma levels IL-27, ox-LDL, analyzed (n = 136) normal subjects (controls, n 29). concentration supernatant...
Abstract Syndecan‐1 ( SDC 1), with a variable ectodomain carrying heparan sulphate HS ) chains between different Syndecans, participates in many steps of inflammatory responses. In the process proteolysis, complete extracellular domain can be shed from cell surface, by which they mediate most 1's function. However, exact impact on 1 anchored surface has not been clearly reported. our study, we established models transfection cleavable resistant mutant plasmid, shedding suppressed during...