A5078468431- RNA Interference and Gene Delivery
- RNA modifications and cancer
- Immunotherapy and Immune Responses
- Nanoplatforms for cancer theranostics
- MicroRNA in disease regulation
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- Ginseng Biological Effects and Applications
- Spine and Intervertebral Disc Pathology
- Cancer-related gene regulation
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Advanced biosensing and bioanalysis techniques
- Ferroptosis and cancer prognosis
- Spinal Fractures and Fixation Techniques
- Spaceflight effects on biology
- HIV Research and Treatment
- Immune Response and Inflammation
- Medicinal Plant Pharmacodynamics Research
- Cancer, Lipids, and Metabolism
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- HIV/AIDS drug development and treatment
- Epigenetics and DNA Methylation
- Autophagy in Disease and Therapy
- Graphene and Nanomaterials Applications
Beijing University of Technology
2016-2025
Mianyang Central Hospital
2025
University of Electronic Science and Technology of China
2024-2025
First Affiliated Hospital of Xinjiang Medical University
2025
Xinjiang Medical University
2025
Chongqing Medical University
2023-2024
Second Affiliated Hospital of Chongqing Medical University
2023-2024
Dalian Medical University
2023-2024
Chinese University of Hong Kong, Shenzhen
2024
Nantong University
2022-2023
Copper is an essential microelement for the body and a necessary coregulator enzymatic reactions, yet unbalanced copper level promotes reactive oxidation cytotoxicity, which ultimately induces cell death. Several small molecules targeting copper-induced death have been investigated, few showed promising therapeutic effects in clinical trials. In March 2022, Science first introduced concept mechanisms of cuproptosis, suggesting that targets tricarboxylic acid (TCA) cycle via protein...
Dural injuries often result in severe complications such as cerebrospinal fluid (CSF) leakage, intracranial infections, and brain herniation, which significantly impact patient recovery quality of life. Conventional dural repair materials, rely on suturing to peripheral tissues, fail promote tissue regeneration provide sufficient CSF leakage prevention, leading suboptimal outcomes. To address these limitations, we developed a Janus adhesive bio-patch with both antibacterial pro-angiogenic...
Background. We recently developed high-throughput assays of inflammation-independent anti-fibrotic activities based on TGF-β1-induced total collagen accumulation and nodule formation in normal rat kidney fibroblasts.
Perfluorooctane sulfonate (PFOS) is a man-made fluorosurfactant and globally persistent organic pollutant. PFOS mainly distributed in blood with long half-life for elimination. was found bound to human serum albumin (HSA) plasma, the most abundant protein which transports variety of endogenous exogenous ligands. However, structural basis such binding remains unclear. Here, we report crystal structure HSA–PFOS complex show that binds HSA at molar ratio 2:1. In addition, renders more compact....
Metastatic relapse is a leading cause of cancer‐associated death and one the major obstacles for effective therapy against triple‐negative breast cancer. To address this problem, miRNA‐delivering nanocapsule technology based on hyaluronic acid (HA)/protamine sulfate (PS) interpolyelectrolyte complexes (HP‐IPECs) developed efficient encapsulation intracellular delivery microRNA‐34a (miR‐34a), which potent endogenous tumor suppressor The nanocapsules are successfully generated through...
The epithelial–mesenchymal transition (EMT) is an important pathological process in the occurrence of pulmonary fibrosis. Changes histone methylation modifications key genes play role this process. As a methyltransferase, regulatory mechanism and SET domain bifurcated 1 (SETDB1) fibrosis remain unclear. We found that SETDB1 inhibited EMT cells attenuated expression to relieve inhibition during transforming growth factor-β (TGF-β)-induced EMT. Silencing significantly enhanced mesenchymal...
Intra-tumoral heterogeneity (ITH) is a distinguished hallmark of cancer, and cancer stem cells (CSCs) contribute to this malignant characteristic. Therefore, it great significance investigate even target the regulatory factors driving intra-tumoral stemness. c-Myc vital oncogene frequently overexpressed or amplified in various types, including breast cancer. Our previous study indicated its potential association with cell (BCSC) biomarkers.In research, we performed immunohistochemical (IHC)...
Antibody-antigen conjugates, which promote antigen-presentation by dendritic cells (DC) means of targeted delivery antigen to particular DC subsets, represent a powerful vaccination approach. To ensure immunity rather than tolerance induction the co-administration suitable adjuvant is paramount. However, unlinked cannot that all antibody conjugates are appropriately activated. Furthermore, antigen-presenting (APC) do not present desired equally strongly activated and could prime undesired...
A multifunctional nanodiamond-based theranostic nanoplatform was fabricated that exhibited enhanced mild-temperature photothermal/chemo combination therapy efficiency via an autophagy regulation strategy against triple negative breast cancer.
Introduction: Tumor vaccines that induce robust humoral and cellular immune responses have attracted tremendous interest for cancer immunotherapy. Despite the potential of tumor as an effective approach treatment prevention, a major challenge in achieving sustained antitumor immunity is inefficient antigen delivery to secondary lymphoid organs, even with adjuvant aid. Methods: Herein, we present antigen/adjuvant integrated nanocomplexes termed nsGO/PCP/OVA by employing graphene oxide...
We report an innovative approach for miRNA-203 delivery in esophageal cancer cells using protamine sulphate (PS)–nanodiamond (ND) nanoparticles. The efficient of miR-203 significantly suppressed the proliferation and migration through targeting Ran ΔNp63, exhibiting a great potential PS@ND nanoparticles miRNA-based therapy.
Deficits in cognitive functioning have been reported humans exposed to dioxins and dioxin-like compounds. Evidence suggests that induce cholinergic dysfunction mediated by hypothyroidism. However, little is known about direct effects of on the system.We investigated action 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) acetylcholinesterase (AChE), a key enzyme neurotransmission.We used SK-N-SH human-derived neuronal cells evaluate effect dioxin exposure AChE.We consistently found significant...
Abstract Replacement of downregulated tumor‐suppressive microRNA (Ts‐miRNA) is recognized as an alternative approach for tumor gene therapy. However, in situ monitoring miRNA replacement efficacy a real‐time manner via noninvasive imaging continually challenging. Here, glutathione (GSH)‐activated light‐up peptide‐polysaccharide‐inter‐polyelectrolyte nanocomplexes are established through self‐assembly carboxymethyl dextran with disulfide‐bridged (“SS”) oligoarginine peptide (S‐Arg 4 ), which...
Abstract Background Panax notoginseng (Burk.) F. H. Chen ( P. ) is a traditional Chinese medicine that has been used therapeutically for cardiovascular diseases, inflammatory diseases and traumatic injuries as well external internal bleeding due to injury. Ginsenoside Rb1, crucial monomeric active constituent extracted from , attracted widespread attention because of its potential anti-inflammatory, bacteriostatic, cell growth-promoting effects. In this study, the therapeutic effects...
A multicomponent-assembled nanodiamond hybrid theranostic nanoplatform exhibits Cur/PDT/PTT ternary collaborative triple-negative breast cancer therapy <italic>via</italic> curcumin and IR780 co-delivery.
The purpose of this study was to analyze the outcomes and influencing factors patients with community-acquired pressure injuries (CAPIs) provide insights for clinical practice. Retrospective cohort study. We reviewed medical records 413 a total 522 CAPIs. Patients CAPIs who were hospitalized at Mianyang Central Hospital, Sichuan Province, China, between December 2021 2022. Depending on CAPI outcome time discharge, split into "improvement" "no improvement" groups. Factors examined using...
During medium- to long-duration spaceflights, real-time microgravity can increase the health risks of astronauts. In particular, disruption intestinal homeostasis is closely related other problems, and it necessary monitor treatment strategies. Ginseng a well-known Chinese herbal medicine often used maintain health. total saponins (GTSs), which are bioactive components ginseng, have been reported regulate immune homeostasis, anti-inflammation, anti-oxidation. This study focused on regulation...
pH-Induced charge-reversal nanoparticles incorporating microRNA (miRNA) were engineered through a single-step self-assembly of polyelectrolyte complexes.
In the present study, we evaluated adjuvant potential of Poria cocos polysaccharide (PCP) on Th1-type immune responses C57/BL6 mice against ovalbumin (OVA). We first determined effect PCP maturation murine bone marrow derived dendritic cells (BMDCs), significantly upregulated surface expression MHCII, CD40, CD80, CD86 and enhanced production IL-6 IL-12p40. addition, affected receptor-mediated endocytosis, but not pinocytosis in BMDCs. Furthermore, OVA + immunization induced specific...