A5034352875- Phytochemistry and Biological Activities
- Natural product bioactivities and synthesis
- Metabolomics and Mass Spectrometry Studies
- Traditional Chinese Medicine Studies
- Traditional Chinese Medicine Analysis
- Microbial Natural Products and Biosynthesis
- Pharmacological Effects of Natural Compounds
- Advances in Cucurbitaceae Research
- Plant biochemistry and biosynthesis
- Phytochemical Studies and Bioactivities
- Plant-based Medicinal Research
- Chemical synthesis and alkaloids
- Essential Oils and Antimicrobial Activity
- Plant Toxicity and Pharmacological Properties
- Computational Drug Discovery Methods
- Cancer Treatment and Pharmacology
- Sesquiterpenes and Asteraceae Studies
- Bioactive Compounds and Antitumor Agents
- Fungal Biology and Applications
- Phytochemicals and Antioxidant Activities
- Synthesis and biological activity
- Phytochemistry and Bioactive Compounds
- Bryophyte Studies and Records
- Natural Antidiabetic Agents Studies
- Steroid Chemistry and Biochemistry
King's College London
2010-2022
Kwame Nkrumah University of Science and Technology
2005
Imperial College London
2004
Ludwig-Maximilians-Universität München
1998
Technical University of Munich
1996
University of London
1976-1987
National Institutes of Health
1987
Chinese Academy of Medical Sciences & Peking Union Medical College
1987
Academy of Medical Sciences
1987
Academia Sinica
1987
Seventeen patients who ate fresh leaves of feverfew daily as prophylaxis against migraine participated in a double blind placebo controlled trial the herb: eight received capsules containing freeze dried powder and nine placebo. Those had significant increase frequency severity headache, nausea, vomiting with emergence untoward effects during early months treatment. The group given showed no change or symptoms migraine. This provides evidence that taken prophylactically prevents attacks...
A cell culture of Taxus chinensis was established to produce the diterpene 2alpha,5alpha,10beta,14beta-tetra-acetoxy4 ++ +(20),11-taxadiene (taxuyunnanine C) in 2.6% (dry weight) yield. The incorporation [U-13C6]glucose, [1-13C]glucose, and [1,2-13C2]acetate into this analyzed by NMR spectroscopy. Label from diverted four acetyl groups taxuyunnanine C, but not taxane ring system. [1-13C]glucose [U-13C6]glucose efficiently incorporated both system groups. isoprenoid moieties showed identical...
A metabonomic strategy, utilizing high-resolution 1H NMR spectroscopy in conjunction with chemometric methods (discriminant analysis orthogonal signal correction), has been applied to the study of human biological responses chamomile tea ingestion. Daily urine samples were collected from volunteers during a 6-week period incorporating 2-week baseline period, 2 weeks daily ingestion, and post-treatment phase. Although strong intersubject variation metabolite profiles was observed, clear...
Background. We recently developed high-throughput assays of inflammation-independent anti-fibrotic activities based on TGF-β1-induced total collagen accumulation and nodule formation in normal rat kidney fibroblasts.
In order to improve the accuracy and consistency of control phytomedicine preparations worldwide, regulatory authorities are requesting research into new analytical methods for stricter standardisation phytomedicines. Such have be both objective robust, should address reproducibility content chemical profiles. NMR-based metabolomics, which combines high-resolution 1H-NMR spectroscopy with chemometric analysis, has been employed as an innovative way meet those demands. this paper, chamomile...
Two databases have been constructed to facilitate applications of cheminformatics and molecular modeling medicinal plants. The first contains data on known chemical constituents 240 commonly used Chinese herbs, the other information target specificities bioactive plant compounds. Structures are available for all In case herbal database, further details include trivial systematic names, compound class skeletal type, botanical (pinyin) names associated herb(s), CAS registry number, chirality,...
Random Forest, a form of multiple decision trees, has been used to screen database Chinese herbal constituents for potential inhibitors against several therapeutically important molecular targets. These comprise cyclic adenosine 3'-5'-monophosphate phosphodiesterases, protein kinase A, cyclooxygenases, lipoxygenases, aldose reductase, and three HIV targets-integrase, protease, reverse transcriptase. In addition, compounds were identified which may inhibit the expression inducible nitric...
GP-TCM is the 1st EU-funded Coordination Action consortium dedicated to traditional Chinese medicine (TCM) research. This paper aims summarise objectives, structure and activities of introduces position regarding good practice, priorities, challenges opportunities in TCM Serving as introductory for Journal Ethnopharmacology special issue, this describes roadmap issue reports how main outputs ten work packages are integrated, have led consortium-wide conclusions. Literature studies, opinion...
Antimicrobial screening of several lichen species and subsequent isolation structure elucidation active compounds revealed that the hydrolysis products certain metabolites, i.e., depsides, were against gram-negative bacteria fungi as well gram-positive bacteria. The constituents isolated from Stereocaulon alpinum Peltigera aphthosa identified, respectively, methyl beta-orsellinate a mixture ethyl orsellinates. MIC determinations indicated activity these was superior to commonly used...
Mezoneuron benthamianum, Securinega virosa and Microglossa pyrifolia are used in folk medicine Ghana for the treatment of dermal infections wounds. Petroleum spirit, chloroform ethanol extracts plants were tested antimicrobial activity against a battery organisms using agar well diffusion technique serial dilution microassay. The resistance modifying activities these on standard antibiotics Staphylococcus aureus possessing efflux mechanisms have also been assessed. A 4-fold potentiation...
Distribution patterns of 8411 compounds from 240 Chinese herbs were analyzed in relation to the herbal categories traditional medicine (TCM), using Random Forest (RF) and self-organizing maps (SOM). RF was used first construct TCM profiles individual compounds, which describe their affinities for 28 major categories, while simultaneously minimizing level noise associated with complex array diverse phytochemicals found each category. Profiles then reduced visualized SOM. The distribution 10...
There is increasing interest in evaluating the clinical efficacy of herbal medicines. However, there are significant analytical problems associated with quality control and measurement overall composition such complex, multi-component mixtures as normally required pharmaceutical industry. Here we describe a novel NMR spectroscopic pattern recognition approach to investigate variability commonly used medicine. 600 MHz 1H-NMR spectroscopy principal components analysis (PCA) was discriminate...
An extract from Jatropha curcas seeds, purified by gel filtration on Sephadex G-75 and Sephacryl S-200, yielded an active hemagglutinin of high purity as assessed electrophoresis isoelectric focussing. The had a molecular weight around 660,000 pI value 5.75. molecule was composed two different subunits weights 23,450 11,500. Amino acid analysis suggested that the lacked 1/2 cystine but contained proportion acidic basic amino acids. Agglutination trypsinized erythrocytes, groups A, B O, took...
A major toxicological challenge is distinguishing whether morphine in urine, the absence of 6-monoacetylmorphine (6-MAM), originates from 'street' heroin use or poppy seed ingestion. Manufacturing byproducts synthesis illicit include those that originate reaction acetic anhydride with alkaloid impurity, thebaine, which undergoes skeletal rearrangement, resulting compounds a 2-(N-methylacetamido)ethyl side-chain. The hypothesis tertiary amide this side-chain resistant to endogenous hydrolysis...