A5100409879- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Cancer Immunotherapy and Biomarkers
- Circular RNAs in diseases
- Ferroptosis and cancer prognosis
- Lung Cancer Treatments and Mutations
- Immune Cell Function and Interaction
- Epigenetics and DNA Methylation
- Lung Cancer Research Studies
- Cancer Genomics and Diagnostics
- Immunotherapy and Immune Responses
- Immune cells in cancer
- Cancer Treatment and Pharmacology
- Cancer Mechanisms and Therapy
- Cancer, Lipids, and Metabolism
- RNA Research and Splicing
- Hepatocellular Carcinoma Treatment and Prognosis
- Genetic factors in colorectal cancer
- Prostate Cancer Treatment and Research
- Colorectal Cancer Treatments and Studies
- Cancer-related gene regulation
- Hepatitis B Virus Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- CAR-T cell therapy research
Zhujiang Hospital
2016-2025
Southern Medical University
2016-2025
Vanderbilt University Medical Center
2016-2025
Zhengzhou University
2014-2025
Harbin Medical University
2016-2025
Fudan University Shanghai Cancer Center
2016-2025
Guiyang Medical University
2018-2025
China Medical University
2012-2025
First Hospital of China Medical University
2010-2025
Peking University People's Hospital
2008-2025
Attack by reactive oxygen intermediates, common to many kinds of cell/tissue injury, has been implicated in the development diabetic and other vascular diseases. Such oxygen-free radicals can be generated advanced glycation end products (AGEs), which are nonenzymatically glycated oxidized proteins. Since cellular interactions AGEs mediated specific binding proteins, receptor for AGE (RAGE) lactoferrin-like polypeptide (LF-L), we tested hypothesis that ligands tethered complex RAGE LF-L could...
Vascular cell adhesion molecule-1 (VCAM-1), an inducible cell-cell recognition protein on the endothelial surface (EC), has been associated with early stages of atherosclerosis. In view accelerated vascular disease observed in patients diabetes, and enhanced expression VCAM-1 diabetic rabbits, we examined whether irreversible advanced glycation endproducts (AGEs), could mediate by interacting their receptor (receptor for AGE, RAGE). Exposure cultured human ECs to AGEs induced VCAM-1,...
VegT is a T-box transcription factor whose mRNA synthesized during oogenesis and localized in the vegetal hemisphere of egg early embryo. We show that maternally expressed controls pattern primary germ layer specification Xenopus embryos. Reduction maternal store completely alters fates different regions blastula so animal cell fate changed from epidermis nervous system to only, equatorial mesoderm ectoderm, endoderm ectoderm. Vegetal cells lose their capacity both form release...
Abstract NF-κB signaling has been discovered for nearly 40 years. Initially, was identified as a pivotal pathway in mediating inflammatory responses. However, with extensive and in-depth investigations, researchers have that its role can be expanded to variety of mechanisms, biological processes, human diseases, treatment options. In this review, we first scrutinize the research process signaling, summarize composition, activation, regulatory mechanism signaling. We investigate interaction...
Abstract Adenocarcinoma is the most common type of lung cancer, leading cause cancer deaths in world. Early detection key to improve survival adenocarcinoma patients. We have previously shown that microRNAs (miRNAs) were stably present sputum and could be applied diagnosis cancer. The aim our study was develop a panel miRNAs can used as highly sensitive specific markers for early adenocarcinoma. Our contained 3 phases: ( i ) marker discovery using miRNA profiling on paired normal tumor...
Colorectal cancer(CRC) patients have derived clinical benefits from immunotherapy, especially CRC with mismatch repair deficiency (dMMR)/microsatellite instability-high(MSI-H), whose sensitivity to immune checkpoint inhibitors(ICIs) is significantly higher than that of microsatellite-stable(MSS)/microsatellite instability-low(MSI-L). Most studies not systematically evaluated the characteristics and microenvironments MSI-H MSS/MSI-L CRC. We analyzed relationship between MSI status prognosis...
Congenital scoliosis is a common type of vertebral malformation. Genetic susceptibility has been implicated in congenital scoliosis.
Apatinib is an oral, highly potent tyrosine-kinase inhibitor targeting VEGFR2. Phase I study showed the recommended dose of 750 mg/day with substantial antitumor activity. This phase II aims to evaluate optimum level for efficacy and safety apatinib monotherapy in heavily pretreated patients metastatic triple negative breast cancer (mTNBC) China. IIa was first performed among 25 previously treated anthracycline and/or taxane. All received p.o. a 4-week cycle. Subsequently, IIb 59 activated,...
The development and progression of hepatocellular carcinoma (HCC) are dependent on its local microenvironment. Hypoxia inflammation two critical factors that shape the HCC microenvironment; however, interplay between involvement cancer cells under such conditions remain poorly understood. We found tumor‐associated macrophages, primary proinflammatory within tumors, secreted more interleukin 1β (IL‐1β) moderate hypoxic due to increased stability hypoxia inducible factor 1α (HIF‐1α). Under...
Abstract Kawasaki disease (KD) is the most common cause of pediatric cardiac in developed countries, and can lead to permanent coronary artery damage long term sequelae such as aneurysms. Given prevalence severity KD, further research warranted on its pathophysiology. It known that endothelial cell inflammation are two essential processes resulting dysfunction KD. However, detailed mechanisms largely unknown. In this study, we investigated role pyroptosis setting hypothesized may play a...
Fibrosis is a common phenotype that often leads to the progression of blood pressure-induced chronic kidney disease (CKD). TGF-beta plays an important role in promoting pathogenesis,and NLRP3 critical mediator CKD. However, pathophysiological roles TGF-beta- mediated pathway modulating fibrosis CKD have not been elucidated. The present study aims investigate contribution TGF-beta-mediated inflammasome renal mice with high pressure. By treating rats angiotensin II (Ang II) for 14 days, we...
Aortic aneurysm/dissection (AAD) is a life-threatening disorder lacking effective pharmacotherapeutic remedies. Aldehyde dehydrogenase 2 (ALDH2) polymorphism tied with various risk factors for AAD including hypertension, atherosclerosis, and hypercholesterolaemia although direct correlation between the two remains elusive.Two independent case-control studies were conducted involving 307 patients 399 healthy controls in geographically distinct areas China. Our data revealed that subjects...
Abstract Background Small cell lung cancer (SCLC) is the most aggressive subtype of cancer. Although patients are initially sensitive to first-line combination chemotherapy with cisplatin and etoposide, drug resistance easily develops quickly leads tumour progression. Therefore, understanding mechanisms how reverse it key improving prognosis SCLC. Moreover, N6-methyladenosine (m6A) abundant mRNA modification catalysed by methyltransferase complex, in which methyltransferase-like 3 (METTL3)...
With the increasing use of immune checkpoint inhibitors (ICIs) for tumour immunotherapy, immune-related adverse events (irAEs) caused by their collateral effect on system pose a key challenge clinical application ICIs. Psychiatric are class associated with ICIs that realistically observed in real world. We aim to provide comprehensive study and summary psychiatric ICIs.We obtained ICI reaction reports during January 2012-December 2021 from FDA Adverse Event Reporting System (FAERS) database....
Abstract Immune checkpoint inhibitors (ICIs) have completely changed the approach pertaining to tumor diagnostics and treatment. Similarly, immunotherapy has also provided much needed data about mutation, expression prognosis, affording an unprecedented opportunity for discovering candidate drug targets screening immunotherapy-relevant biomarkers. Although existing web tools enable biologists analyze expression, mutation prognostic of tumors, they are currently unable facilitate mining...
Rationale: Accumulating evidence demonstrated that long noncoding RNAs (lncRNAs) involved in the regulation of immune system and displayed a cell-type-specific pattern cell subsets. Given vital role tumor-infiltrating lymphocytes effective immunotherapy, we explored cell-associated lncRNA (TIIClncRNA) low-grade glioma (LGG), which has never been uncovered yet. Methods: This study utilized novel computational framework 10 machine learning algorithms (101 combinations) to screen out...