A5073681238- Lung Cancer Treatments and Mutations
- MicroRNA in disease regulation
- Lung Cancer Research Studies
- Extracellular vesicles in disease
- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Treatments and Studies
- Epigenetics and DNA Methylation
- Ovarian cancer diagnosis and treatment
- Cancer-related molecular mechanisms research
- HER2/EGFR in Cancer Research
- Circular RNAs in diseases
- Cancer Treatment and Pharmacology
- Ferroptosis and cancer prognosis
- Immune cells in cancer
- Endometrial and Cervical Cancer Treatments
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Angiogenesis and VEGF in Cancer
- Lung Cancer Diagnosis and Treatment
- Cancer Cells and Metastasis
- Renal cell carcinoma treatment
- Cancer Genomics and Diagnostics
- Gastric Cancer Management and Outcomes
- RNA Research and Splicing
- Cervical Cancer and HPV Research
Union Hospital
2016-2025
Huazhong University of Science and Technology
2016-2025
Fudan University Shanghai Cancer Center
2015-2025
Shanghai Medical College of Fudan University
2014-2025
Army Medical University
2018-2025
Fudan University
2010-2025
Shanghai University of Traditional Chinese Medicine
2025
North China University of Science and Technology
2014-2024
Renmin Hospital of Wuhan University
2015-2023
Zhongda Hospital Southeast University
2018-2023
Apatinib is an oral, highly potent tyrosine-kinase inhibitor targeting VEGFR2. Phase I study showed the recommended dose of 750 mg/day with substantial antitumor activity. This phase II aims to evaluate optimum level for efficacy and safety apatinib monotherapy in heavily pretreated patients metastatic triple negative breast cancer (mTNBC) China. IIa was first performed among 25 previously treated anthracycline and/or taxane. All received p.o. a 4-week cycle. Subsequently, IIb 59 activated,...
The tumor-adipose microenvironment (TAME) is a universal microecosystem, that characterized by the dysfunction of lipid metabolism, such as excessive free fatty acids (FFAs). Macrophages are most abundant immune cell type within TAME, although their diversity in TAME not clear. We first reveal infiltration M2-like macrophages associated with poor survival breast cancer. To explore lipid-associated alterations we also detected levels FFAs transporters including acid binding proteins (FABPs)...
Acidity is a hallmark of malignant tumor, representing very efficient mechanism chemoresistance. Proton pump inhibitors (PPI) at high dosage have been shown to sensitize chemoresistant human tumor cells and tumors cytotoxic molecules. The aim this pilot study was investigate the efficacy PPI in improving clinical outcome docetaxel + cisplatin regimen patients with metastatic breast cancer (MBC).
Abstract Background Human epidermal growth factor receptor 2 (HER2) is the most crucial ErbB tyrosine kinase (RTK) family member in HER2-positive (refered to HER2-overexpressing) breast cancer which are dependent on or "addictive" Phosphatidylinositol-3-kinase (PI3K) pathway. HER2-related target drugs trastuzumab and lapatinib have been foundation of treatment HER2--positive cancer. This study was designed explore relationship between PI3K pathway activation sensitivity metastatic patients...
Abstract Despite the promise of ribonucleic acid interference therapeutics, delivery oligonucleotides selectively to diseased tissues in body, and specifically cellular location needed provide optimal therapeutic outcome, remains a significant challenge. Here, key material properties biological mechanisms for short interfering RNAs (siRNAs) effectively silence target‐specific cells vivo are identified. Using porous silicon nanoparticles as siRNA host, tumor‐targeting peptides selective...
Background: Ovarian cancer is a fatal malignant gynecological tumor. stem cells (OCSCs) contribute to resistance chemotherapy. The polycomb group protein enhancer of zeste homolog 2 (EZH2) plays key role in maintaining CSCs. Here, we aimed investigate the specific mechanism by which EZH2 regulates CSCs result chemoresistance and poor prognosis ovarian cancer. Methods: We used nude mouse model obtain cell line enriched for OCSCs, named SK-3rd cells. CRISPR Cas9 endonuclease system was...
Enhancer of zeste homolog 2 (EZH2) is often increased in malignant tumors and involved metastasis. EZH2 silences gene expression by tri-methylating the lysine 27 residue histone H3 (H3K27me3). However, mechanism underlying promotion ovarian cancer metastasis remains elusive. Here, we showed that up-regulated associated with tumor poor survival mRNA sequencing microarray results from databases. Tissue immunohistochemistry revealed was negatively correlated tissue inhibitor metalloproteinases...
Statement of RetractionWe, the Editors and Publisher journal Adipocyte have retracted following article:Breast cancer-released exosomes trigger cancer-associated cachexia to promote tumor progression (DOI: 10.1080/21623945.2018.1551688)Since publication, concerns been raised about integrity data in article, alongside images text overlap with previously published articles. When approached for an explanation, authors checked their confirmed there are fundamental errors present they agree...
This study aimed to construct an m6A-related long non-coding RNAs (lncRNAs) signature accurately predict the prognosis of kidney clear cell carcinoma (KIRC) patients using data obtained from The Cancer Genome Atlas (TCGA) database.The KIRC patient were downloaded TCGA database and genes published articles. Pearson correlation analysis was implemented identify lncRNAs. Univariate, Lasso, multivariate Cox regression analyses used identifying prognostic risk-associated Five lncRNAs identified a...
Background: Immune checkpoint blockers (ICBs) are revolutionized therapeutic strategies for cancer, but most patients with solid neoplasms remain resistant to ICBs, partly because of the difficulty in reversing highly immunosuppressive tumor microenvironment (TME).Exploring immunotherapy is dependent on discovery molecular mechanisms immune escape and potential target.Krüppel-like Factor 5 (KLF5) a cell-intrinsic oncogene promote tumorigenesis.However, cell-extrinsic effects KLF5 suppressing...
Thoracic SMARCA4-deficient undifferentiated tumor (SD-UT) is a highly aggressive disease that nosologically related to but distinct from non-small cell lung cancer (SD-NSCLC). No standard treatment guidelines were established for SD-UT. This research explored the efficacy of different treatments in SD-UT, and prognostic, clinicopathologic genomic difference between SD-UT SD-NSCLC.Information 25 22 SD-NSCLC patients diagnosed treated Fudan University Shanghai Cancer Center January, 2017...
A useful Cu-catalyzed cycloaddition protocol for the construction of benzene rings has been achieved. The reactions, utilizing readily available oximes and maleimides as starting materials, proceed under mild reaction conditions to generate a series structurally interesting fused-phthalimides that are difficult be prepared by conventional methods.
Controlled self-assembly has attracted extensive interest in biological and nanotechnological applications. Enzymatic or biocatalytic triggered is widely used for the diagnostic prognostic marker different pathologies because of their nanostructures effects. However, it remains a great challenge to control peptides living cells with high degree spatial temporal precision. Here we demonstrate light-triggered platform that enables spatiotemporal from nanoparticles into nanofibers through...