A5082903454- Extracellular vesicles in disease
- Cancer Treatment and Pharmacology
- MicroRNA in disease regulation
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- Lung Cancer Treatments and Mutations
- Metastasis and carcinoma case studies
- Colorectal Cancer Treatments and Studies
- Social Media in Health Education
- Cancer-related molecular mechanisms research
- Advanced Breast Cancer Therapies
- HER2/EGFR in Cancer Research
- Chromatin Remodeling and Cancer
- Health Literacy and Information Accessibility
- Immune Cell Function and Interaction
- Cancer Mechanisms and Therapy
- Cancer Research and Treatments
- Galectins and Cancer Biology
- PARP inhibition in cancer therapy
- DNA Repair Mechanisms
- Neuroendocrine Tumor Research Advances
- Circular RNAs in diseases
- Breast Cancer Treatment Studies
Fudan University Shanghai Cancer Center
2015-2025
Shanghai Medical College of Fudan University
2015-2025
Jinan University
2024-2025
Red Cross Hospital
2024
Guangzhou Blood Center
2024
Sun Yat-sen University
2023
The First Affiliated Hospital, Sun Yat-sen University
2023
Osaka University
2018-2022
Fudan University
2012-2022
The First People's Hospital of Zhaoqing
2022
Abstract Background YouTube, a widely recognized global video platform, is inaccessible in China, whereas Bilibili and TikTok are popular platforms for long short videos, respectively. There many videos related to laryngeal carcinoma on these platforms. This study aims identify upload sources, contents, feature information of Bilibili, TikTok, further evaluate the quality. Methods On January 1, 2024, we searched top 100 by default sort order (300 total) with terms “laryngeal carcinoma”...
BackgroundCBCSG006 trial reported the superior efficacy of cisplatin plus gemcitabine (GP) regimen than paclitaxel (GT) as first-line treatment metastatic triple-negative breast cancer (mTNBC). This study focused on updated survival data and explorations potential biomarkers for efficacy.Patients methodsGerm-line mutations homologous recombination (HR) panel, BRCA1/2 included, were evaluated in 55.9% (132/236) patients. PD-L1 expression was 48.3% (114/236) A nonparametric sliding-window...
Thoracic SMARCA4-deficient undifferentiated tumor (SD-UT) is a highly aggressive disease that nosologically related to but distinct from non-small cell lung cancer (SD-NSCLC). No standard treatment guidelines were established for SD-UT. This research explored the efficacy of different treatments in SD-UT, and prognostic, clinicopathologic genomic difference between SD-UT SD-NSCLC.Information 25 22 SD-NSCLC patients diagnosed treated Fudan University Shanghai Cancer Center January, 2017...
// Congqi Dai 1, * , Fengjuan Lin Ruixuan Geng 1 Xiaoxiao Ge Wenbo Tang Jinjia Chang Zheng Wu Xinyang Liu Ying Zhe Zhang Jin Li 2 Department of Medical Oncology, Fudan University Shanghai Cancer Center; College, University, Shanghai, China Tongji Tianyou Hospital, These authors have contributed equally to this work Correspondence to: Li, e-mail: tianyoulijin@163.com Keywords: PD-L1/PD-1, CIK, NKG2D, immunotherapy, gastrointestinal tumor Received: October 21, 2015 Accepted: January 24, 2016...
Abstract Background Acute leukemia (AL) not only impairs the quality of life (QOL) patients, but also affects that their family caregivers (FCs). Studies on QOL AL patients and FCs are limited. This study aimed to evaluate FCs, explore factors associated with FCs. Methods A multicenter cross-sectional was conducted. The 196 patient–FC dyads assessed. Functional Assessment Cancer Therapy-Leukemia (FACT-Leu) used for 36-item Short-Form Health Survey (SF-36) Independent-samples t-tests or...
MicroRNAs (miRNAs) regulate the expression of genes involved in various cellular functions related to metabolism, inflammation, and reproduction. This study evaluated effects sex hormones obesity on circulating miR-23a miR-23b women with polycystic ovary syndrome (PCOS) healthy women.Serum concentrations body mass index (BMI) were measured 18 PCOS 30 from East China area these measurements correlated serum miR-23a/b levels. The effect risk factors occurrence predisposing miRNA expressions...
Pyrotinib is a newly-developed irreversible pan-ErbB receptor tyrosine kinase inhibitor. This study reported the first real-world data of pyrotinib-based therapy in metastatic human epidermal growth factor 2 (HER2)-positive breast cancer (BC), focusing on efficacy lapatinib-treated patients and brain metastasis.One hundred thirteen with HER2-positive BC treated Fudan University Shanghai Cancer Center under non-clinical trial settings from September 1, 2018 to March 2019 were included.Over...
Objective: This study aims to investigate perinatal depression in women who gave birth during the COVID-19 pandemic Wuhan, and evaluate effect of on prevalence. Methods: A cross-sectional investigation was conducted into hospitalized for delivery Hubei Maternity Child Healthcare Hospital from December 31, 2019 March 22, 2020, a period which encompasses entire time frame Wuhan. The Edinburgh Postnatal Depression Scale (EPDS) adopted status. Chi-square test logistic regression model were...
Abstract Background Etrasimod (ETR) is an oral, once daily (qd), selective sphingosine 1-phosphate (S1P)1,4,5 receptor modulator for the treatment of moderately to severely active ulcerative colitis (UC). ES101002 was a registrational Phase (Ph) 3 study evaluating efficacy and safety ETR in Asian patients (pts) with UC (NCT04176588). has shown significant benefit vs placebo (PBO) as induction maintenance therapy pts UC, including 12-week (wk) period (IP) ES101002.1–4 Here, we report results...
Checkpoint blockade combined with chemotherapy has become an important treatment option for lung cancer patients in clinical settings. However, biomarkers that effectively identify true responders remain lacking. We assessed the potential of plasma small extracellular vesicle (sEV)-derived microRNAs (miRNAs) as predicting and identifying to immunochemotherapy. A total 29 adenocarcinoma who received pembrolizumab pemetrexed carboplatin were enrolled. The efficacy evaluation revealed 24...
Growing evidence suggests that protocadherins ( PCDH ) play crucial roles in pathogenesis and progression of cancers, including gastric cancer GC ). Protocadherin‐8 8 was previously reported to be involved metastasis , but functional studies yielded inconsistent results the molecular mechanism remained unknown. The present study aimed explore clinical relevance, function . Data from GEPIA Kaplan–Meier plotter databases showed high expression significantly correlated with poorer prognosis...
Visceral adipose tissue‑derived serine protease inhibitor (vaspin) is a novel adipokine with potential insulin‑sensitizing properties, which was initially detected in the visceral tissue of genetically obese rats. Previous studies have demonstrated that vaspin exerts protective effect on arteries undergoing atherosclerosis vitro, and it has been shown to exert anti‑inflammatory antimigratory effects vascular smooth muscle cells. Vaspin promotes proliferation inhibits apoptosis endothelial...
Background: The health levels of young elderly individuals are generally low due to multiple factors. This study sought analyze factors that affect the provide a reference for improving their level health.
Objective: To explore the risk fall death associated with compound hot extremes. Methods: This study collected data on deaths in Guangdong, Hunan, and Zhejiang Provinces from 2013 to 2018 matched their exposure meteorological data. Based a time-stratified case-crossover design, conditional logistic regression model embedded cross-basis function of distributed lag nonlinear was applied estimate due Results: Compared regular days, extremes significantly increased falls (OR=1.19, 95%CI:...
Better biomarkers are needed to improve the efficacy of immune checkpoint inhibitors in lung adenocarcinoma (LUAD) treatment. We investigated plasma extracellular vesicle (EV)-derived long RNAs (exLRs) unresectable/advanced LUAD explore for immunochemotherapy. Seventy-four patients without targetable mutations receiving first-line anti-programmed cell death 1 (PD-1) immunochemotherapy were enrolled. Their exLRs profiled through EV transcriptome sequencing. Biomarkers analyzed against...
Functional impairment scales are increasingly used to evaluate subjects with a variety of mental disorders.We evaluated the work, social, and family disabilities 228 6 common anxiety depressive disorders, as assessed by Sheehan Disability Scale (major depression, panic disorder, generalized social phobia, obsessive-compulsive mixed depression).Subjects in diagnostic groups had significantly higher disability scores than control subjects, exception phobia disorder subjects' for disability....
Abstract In non-small-cell lung cancer, mutation of epidermal growth factor receptor (EGFR) stimulates cell proliferation and survival. EGFR tyrosine kinase inhibitors (EGFR-TKIs) such as erlotinib are used first-line therapy with drastic immediate effectiveness. However, the disease eventually progresses in most cases within a few years due to development drug resistance. Here, we explored role progesterone membrane component 1 (PGRMC1) acquired resistance addressed molecular mechanism...
Apatinib is a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor receptor 2. This study aimed to evaluate the efficacy and safety of apatinib in metastatic breast cancer (MBC) under non-clinical trial setting, impact previous antiangiogenic treatment apatinib. 52 MBC patients treated with setting Fudan University Shanghai Cancer Center between January 1st 2015 October 2016 were included. All included time-to-treatment failure (TTF) analysis, while 45 enrolled for...
Animal experiments have shown the anticancer activity of Toxoplasma gondii (T. gondii), but its effect on prognosis cancer patients is unclear. Thus, present study aimed to investigate prognostic role anti-T. IgG in breast and modification cytokines.A total 1121 were recruited between 2008 2018 followed up until December 31, 2021. Anti-T. cytokines measured using an enzyme-linked immunosorbent assay (ELISA) kit a multiplex platform. Endpoints overall survival (OS) progression-free (PFS)....
Recent advances in nanotechnology have led to the development of nanoparticles with innovative functions various fields. However, biological effects nanoparticles—particularly those on fetus—need be investigated detail, because several previous studies shown that induce pregnancy complications mice. In this regard, our findings mice suggested increase peripheral neutrophil count induced by treatment silica a diameter 70 nm (nSP70) may play role associated complications. Therefore, here, we...
// Zheng Wu 1, 2, * , Zhe Zhang Xiaoxiao Ge 2 Ying Lin Congqi Dai Jinjia Chang Xinyang Liu Ruixuan Geng Chenchen Wang Huan Chen 3 Menghong Sun Weijian Guo Jin Li 1 Department of Medical Oncology, Fudan University Shanghai Cancer Center, 200032, China College, University, Pathology, These authors have contributed equally to this work Correspondence to: Li, e-mail: fudanlijin@163.com Keywords: drug resistance, RON, MET, gastric cancer, targeted therapy Received: April 20,...